| # | Title | Journal | Year | Citations |
|---|
| 1 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 | Cell | 1993 | 11,149 |
| 2 | Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. | EMBO Journal | 1991 | 2,724 |
| 3 | Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis | Nature | 1988 | 1,677 |
| 4 | Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences | EMBO Journal | 1991 | 1,641 |
| 5 | Construction of a broad host range cosmid cloning vector and its use in the genetic analysis of Rhizobium mutants | Gene | 1982 | 945 |
| 6 | The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product | Science | 1992 | 929 |
| 7 | Nucleotide sequences that signal the initiation of transcription and translation inBacillus subtilis | Molecular Genetics and Genomics | 1982 | 839 |
| 8 | A sodium-potassium switch in the formation of four-stranded G4-DNA | Nature | 1990 | 790 |
| 9 | A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family | Nature | 1987 | 782 |
| 10 | Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein | Science | 1986 | 637 |
| 11 | Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2 | Nature | 1996 | 591 |
| 12 | Complex patterns formed by motile cells of Escherichia coli | Nature | 1991 | 510 |
| 13 | Extracellular signals and reversible protein phosphorylation: What to Mek of it all | Cell | 1993 | 463 |
| 14 | Characterization and use of theDrosophilametallothionein promoter in culturedDrosophila melanogastercells | Nucleic Acids Research | 1988 | 446 |
| 15 | Copper staining: A five-minute protein stain for sodium dodecyl sulfate-polyacrylamide gels | Analytical Biochemistry | 1987 | 434 |
| 16 | Compliance of bacterial flagella measured with optical tweezers | Nature | 1989 | 433 |
| 17 | Crisscross regulation of cell-type-specific gene expression during development in B. subtilis | Nature | 1992 | 417 |
| 18 | A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses | Cell | 1989 | 413 |
| 19 | Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development | Mechanisms of Development | 1995 | 412 |
| 20 | Construction of a cloning site near one end of Tn917 into which foreign DNA may be inserted without affecting transposition in Bacillus subtilis or expression of the transposon-borne erm gene | Plasmid | 1984 | 398 |
| 21 | Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function. | Genes and Development | 1993 | 392 |
| 22 | Migration of bacteria in semisolid agar. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 378 |
| 23 | Multi-neuronal signals from the retina: acquisition and analysis | Journal of Neuroscience Methods | 1994 | 368 |
| 24 | The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor | Cell | 1990 | 347 |
| 25 | A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans | Cell | 1989 | 340 |
| 26 | The MotA protein of E. coli is a proton-conducting component of the flagellar motor | Cell | 1990 | 316 |
| 27 | A convenient and adaptable package of computer programs for DNA and protein sequence management, analysis and homology determination | Nucleic Acids Research | 1984 | 314 |
| 28 | Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression. | Journal of Experimental Medicine | 1993 | 308 |
| 29 | An extensive 3′ cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-β family in Drosophila | Development (Cambridge) | 1991 | 300 |
| 30 | DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage. | Molecular and Cellular Biology | 1989 | 299 |
| 31 | Evidence for a common evolutionary origin of inverted repeat transposons in Drosophila and plants: hobo, activator, and Tam3 | Cell | 1991 | 298 |
| 32 | The molecular basis of erythrocyte shape | Science | 1986 | 297 |
| 33 | The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo. | Genes and Development | 1987 | 291 |
| 34 | Restoration of torque in defective flagellar motors | Science | 1988 | 288 |
| 35 | Dopamine enhances excitatory amino acid-gated conductances in cultured retinal horizontal cells | Nature | 1987 | 284 |
| 36 | Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 282 |
| 37 | Chromosomal rearrangement generating a composite gene for a developmental transcription factor | Science | 1989 | 279 |
| 38 | The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila | Cell | 1991 | 276 |
| 39 | A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 270 |
| 40 | The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments | Cell | 1987 | 264 |
| 41 | An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo | Development (Cambridge) | 1993 | 263 |
| 42 | Novel GABA responses from rod- driven retinal horizontal cells | Nature | 1993 | 259 |
| 43 | Early-eye morphogenesis in the zebrafish,Brachydanio rerio | Journal of Comparative Neurology | 1994 | 255 |
| 44 | Cloning of Rhizobium meliloti nodulation genes by direct complementation of Nod− mutants | Nature | 1982 | 249 |
| 45 | Identification and characterization of genes controlled by the sporulation-regulatory gene spo0H in Bacillus subtilis | Journal of Bacteriology | 1989 | 248 |
| 46 | Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6. | Journal of Biological Chemistry | 1991 | 248 |
| 47 | Two RNA polymerase sigma factors from Bacillus subtilis discriminate between overlapping promoters for a developmentally regulated gene | Nature | 1983 | 240 |
| 48 | One-sided polymerase chain reaction: the amplification of cDNA. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 238 |
| 49 | How big is the universe of exons? | Science | 1990 | 236 |
| 50 | Mutants in disulfide bond formation that disrupt flagellar assembly in Escherichia coli. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 236 |
