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Top Articles

#TitleJournalYearCitations
1Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol AEnvironmental Health Perspectives20101,038
2Novel Single Chain cAMP Sensors for Receptor-induced Signal PropagationJournal of Biological Chemistry2004630
3A FlAsH-based FRET approach to determine G protein–coupled receptor activation in living cellsNature Methods2005471
4Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled ReceptorsPLoS Biology2009471
5Measurement of the millisecond activation switch of G protein–coupled receptors in living cellsNature Biotechnology2003400
6Single-molecule analysis of fluorescently labeled G-protein–coupled receptors reveals complexes with distinct dynamics and organizationProceedings of the National Academy of Sciences of the United States of America2013394
7Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β 1 -Adrenergic but Locally Confined β 2 -Adrenergic Receptor–Mediated SignalingCirculation Research2006321
8Widespread Receptivity to Neuropeptide PDF throughout the Neuronal Circadian Clock Network of Drosophila Revealed by Real-Time Cyclic AMP ImagingNeuron2008295
9Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol AEnvironmental Health Perspectives2009268
10Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spotsNature2017258
11Sweet Taste Receptor Expressed in Pancreatic β-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin SecretionPLoS ONE2009254
12Aflatoxin in foodstuffs: Occurrence and recent advances in decontaminationFood Research International2018213
13Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected UroepitheliumCell2014203
14FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cellsNature Protocols2011191
15β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycleNature2016190
16A new type of ERK1/2 autophosphorylation causes cardiac hypertrophyNature Medicine2009189
17Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and resultsNature Protocols2020189
18Analysis of receptor oligomerization by FRAP microscopyNature Methods2009187
19Selenium Supplementation Restores the Antioxidative Capacity and Prevents Cell Damage in Bone Marrow Stromal Cells In VitroStem Cells2006171
20Genotoxicity of singlet oxygenChemico-Biological Interactions1991168
21Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanismProceedings of the National Academy of Sciences of the United States of America2005168
22Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicityCancer Immunology, Immunotherapy2011163
23Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes2004148
24Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcriptionNature Communications2017140
25Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neuronsELife2017138
26Molecular basis of inverse agonism in a G protein–coupled receptorNature Chemical Biology2005137
27The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphataseProceedings of the National Academy of Sciences of the United States of America2003131
28Genotoxicity of phytoestrogensMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2005131
29Optical Mapping of cAMP Signaling at the Nanometer ScaleCell2020125
30Real-time Monitoring of the PDE2 Activity of Live CellsJournal of Biological Chemistry2005122
31[12] Oxidative DNA damage: Endonuclease fingerprintingMethods in Enzymology1994120
32Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptorsTrends in Pharmacological Sciences2008119
33Regional and cellular localization of the CXCl12/SDF‐1 chemokine receptor CXCR7 in the developing and adult rat brainJournal of Comparative Neurology2008118
34Cardiac hypertrophy: Targeting Raf/MEK/ERK1/2-signalingInternational Journal of Biochemistry and Cell Biology2009117
35Ligand-induced Phosphorylation/Dephosphorylation of the Endogenous Bradykinin B2 Receptor from Human FibroblastsJournal of Biological Chemistry1996116
36GS Activation Is Time-limiting in Initiating Receptor-mediated SignalingJournal of Biological Chemistry2006116
37Oxidative DNA damage induced by potassium bromate under cell-free conditions and in mammalian cellsCarcinogenesis1995115
38Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinomaClinical Endocrinology2011110
39Monitoring of Aromatic Amine Exposures in Workers at a Chemical Plant With a Known Bladder Cancer ExcessJournal of the National Cancer Institute1996107
40Effect of Gum Arabic on Oxidative Stress and Inflammation in Adenine–Induced Chronic Renal Failure in RatsPLoS ONE2013107
41The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophyNature Medicine2005105
42Recognition of oxidized abasic sites by repair endonucleasesNucleic Acids Research1994104
43Fluorescence Resonance Energy Transfer Analysis of α2a-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational ChangesMolecular Pharmacology2009103
44Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol AEnvironmental Health Perspectives2010102
45Kinetics of G‐protein‐coupled receptor signals in intact cellsBritish Journal of Pharmacology2008100
46Analysis ofras mutations in human melanocytic lesions: activation of theras gene seems to be associated with the nodular type of human malignant melanomaJournal of Cancer Research and Clinical Oncology199599
47Visible light generates oxidative DNA base modifications in high excess of strand breaks in mammalian cellsCarcinogenesis199497
48Internalization Determinants of the Parathyroid Hormone Receptor Differentially Regulate β-Arrestin/Receptor AssociationJournal of Biological Chemistry200297
49Molecular Basis of Partial Agonism at the Neurotransmitter α2A-Adrenergic Receptor and Gi-protein HeterotrimerJournal of Biological Chemistry200697
50Differential Conformational Requirements for Activation of G Proteins and the Regulatory Proteins Arrestin and G Protein-coupled Receptor Kinase in the G Protein-coupled Receptor for Parathyroid Hormone (PTH)/PTH-related ProteinJournal of Biological Chemistry200195