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Institute of Pharmacology and Toxicology
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top-articles
Institute of Pharmacology and Toxicology
405
(top 1%)
papers
17.7K
(top 1%)
citations
69
(top 1%)
h
-index
117
(top 1%)
g
-index
438
all documents
19.0K
doc citations
2.7K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A
Environmental Health Perspectives
2010
1,038
2
Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation
Journal of Biological Chemistry
2004
630
3
A FlAsH-based FRET approach to determine G protein–coupled receptor activation in living cells
Nature Methods
2005
471
4
Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors
PLoS Biology
2009
471
5
Measurement of the millisecond activation switch of G protein–coupled receptors in living cells
Nature Biotechnology
2003
400
6
Single-molecule analysis of fluorescently labeled G-protein–coupled receptors reveals complexes with distinct dynamics and organization
Proceedings of the National Academy of Sciences of the United States of America
2013
394
7
Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β 1 -Adrenergic but Locally Confined β 2 -Adrenergic Receptor–Mediated Signaling
Circulation Research
2006
321
8
Widespread Receptivity to Neuropeptide PDF throughout the Neuronal Circadian Clock Network of Drosophila Revealed by Real-Time Cyclic AMP Imaging
Neuron
2008
295
9
Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A
Environmental Health Perspectives
2009
268
10
Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots
Nature
2017
258
11
Sweet Taste Receptor Expressed in Pancreatic β-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion
PLoS ONE
2009
254
12
Aflatoxin in foodstuffs: Occurrence and recent advances in decontamination
Food Research International
2018
213
13
Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium
Cell
2014
203
14
FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells
Nature Protocols
2011
191
15
β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle
Nature
2016
190
16
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy
Nature Medicine
2009
189
17
Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results
Nature Protocols
2020
189
18
Analysis of receptor oligomerization by FRAP microscopy
Nature Methods
2009
187
19
Selenium Supplementation Restores the Antioxidative Capacity and Prevents Cell Damage in Bone Marrow Stromal Cells In Vitro
Stem Cells
2006
171
20
Genotoxicity of singlet oxygen
Chemico-Biological Interactions
1991
168
21
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism
Proceedings of the National Academy of Sciences of the United States of America
2005
168
22
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity
Cancer Immunology, Immunotherapy
2011
163
23
Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes
2004
148
24
Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription
Nature Communications
2017
140
25
Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons
ELife
2017
138
26
Molecular basis of inverse agonism in a G protein–coupled receptor
Nature Chemical Biology
2005
137
27
The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase
Proceedings of the National Academy of Sciences of the United States of America
2003
131
28
Genotoxicity of phytoestrogens
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
2005
131
29
Optical Mapping of cAMP Signaling at the Nanometer Scale
Cell
2020
125
30
Real-time Monitoring of the PDE2 Activity of Live Cells
Journal of Biological Chemistry
2005
122
31
[12] Oxidative DNA damage: Endonuclease fingerprinting
Methods in Enzymology
1994
120
32
Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors
Trends in Pharmacological Sciences
2008
119
33
Regional and cellular localization of the CXCl12/SDF‐1 chemokine receptor CXCR7 in the developing and adult rat brain
Journal of Comparative Neurology
2008
118
34
Cardiac hypertrophy: Targeting Raf/MEK/ERK1/2-signaling
International Journal of Biochemistry and Cell Biology
2009
117
35
Ligand-induced Phosphorylation/Dephosphorylation of the Endogenous Bradykinin B2 Receptor from Human Fibroblasts
Journal of Biological Chemistry
1996
116
36
GS Activation Is Time-limiting in Initiating Receptor-mediated Signaling
Journal of Biological Chemistry
2006
116
37
Oxidative DNA damage induced by potassium bromate under cell-free conditions and in mammalian cells
Carcinogenesis
1995
115
38
Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma
Clinical Endocrinology
2011
110
39
Monitoring of Aromatic Amine Exposures in Workers at a Chemical Plant With a Known Bladder Cancer Excess
Journal of the National Cancer Institute
1996
107
40
Effect of Gum Arabic on Oxidative Stress and Inflammation in Adenine–Induced Chronic Renal Failure in Rats
PLoS ONE
2013
107
41
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy
Nature Medicine
2005
105
42
Recognition of oxidized abasic sites by repair endonucleases
Nucleic Acids Research
1994
104
43
Fluorescence Resonance Energy Transfer Analysis of α
2a
-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational Changes
Molecular Pharmacology
2009
103
44
Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A
Environmental Health Perspectives
2010
102
45
Kinetics of G‐protein‐coupled receptor signals in intact cells
British Journal of Pharmacology
2008
100
46
Analysis ofras mutations in human melanocytic lesions: activation of theras gene seems to be associated with the nodular type of human malignant melanoma
Journal of Cancer Research and Clinical Oncology
1995
99
47
Visible light generates oxidative DNA base modifications in high excess of strand breaks in mammalian cells
Carcinogenesis
1994
97
48
Internalization Determinants of the Parathyroid Hormone Receptor Differentially Regulate β-Arrestin/Receptor Association
Journal of Biological Chemistry
2002
97
49
Molecular Basis of Partial Agonism at the Neurotransmitter α2A-Adrenergic Receptor and Gi-protein Heterotrimer
Journal of Biological Chemistry
2006
97
50
Differential Conformational Requirements for Activation of G Proteins and the Regulatory Proteins Arrestin and G Protein-coupled Receptor Kinase in the G Protein-coupled Receptor for Parathyroid Hormone (PTH)/PTH-related Protein
Journal of Biological Chemistry
2001
95
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