| # | Title | Journal | Year | Citations |
|---|
| 1 | Metformin improves healthspan and lifespan in mice | Nature Communications | 2013 | 1,118 |
| 2 | Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies: The Honolulu-Asia Aging Study | Diabetes | 2002 | 1,097 |
| 3 | Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility – Reykjavik Study | Brain | 2011 | 713 |
| 4 | New loci associated with kidney function and chronic kidney disease | Nature Genetics | 2010 | 710 |
| 5 | Genome-wide association analyses identify 18 new loci associated with serum urate concentrations | Nature Genetics | 2013 | 675 |
| 6 | Decreased Muscle Strength and Quality in Older Adults With Type 2 Diabetes: The Health, Aging, and Body Composition Study | Diabetes | 2006 | 601 |
| 7 | Accelerated Loss of Skeletal Muscle Strength in Older Adults With Type 2 Diabetes: The Health, Aging, and Body Composition Study | Diabetes Care | 2007 | 598 |
| 8 | Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes | Diabetes Care | 2009 | 593 |
| 9 | Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2009 | 534 |
| 10 | CSF Aβ 42 levels correlate with amyloid-neuropathology in a population-based autopsy study | Neurology | 2003 | 532 |
| 11 | Change in Muscle Strength Explains Accelerated Decline of Physical Function in Older Women With High Interleukin-6 Serum Levels | Journal of the American Geriatrics Society | 2002 | 528 |
| 12 | Handgrip Strength and Cause-Specific and Total Mortality in Older Disabled Women: Exploring the Mechanism | Journal of the American Geriatrics Society | 2003 | 526 |
| 13 | Daily Activity Energy Expenditure and Mortality Among Older Adults | JAMA - Journal of the American Medical Association | 2006 | 483 |
| 14 | A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs) | PLoS Genetics | 2008 | 415 |
| 15 | Limited literacy and mortality in the elderly | Journal of General Internal Medicine | 2006 | 408 |
| 16 | Red Cell Distribution Width and Mortality in Older Adults: A Meta-analysis | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2010 | 360 |
| 17 | Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study | Diabetologia | 2005 | 351 |
| 18 | Predictive Value of the Short Physical Performance Battery Following Hospitalization in Older Patients | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2011 | 350 |
| 19 | The Impact of Insomnia on Cognitive Functioning in Older Adults | Journal of the American Geriatrics Society | 2001 | 320 |
| 20 | Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly women | International Journal of Obesity | 2004 | 320 |
| 21 | Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction | Nature Genetics | 2010 | 308 |
| 22 | Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: The population-based MRI CAMERA study | Cephalalgia | 2010 | 306 |
| 23 | Reliability and sensitivity to change assessed for a summary measure of lower body function | Journal of Clinical Epidemiology | 2002 | 298 |
| 24 | Assessing the building blocks of functionUtilizing measures of functional limitation | American Journal of Preventive Medicine | 2003 | 293 |
| 25 | Use of the Short Physical Performance Battery Score to Predict Loss of Ability to Walk 400 Meters: Analysis From the InCHIANTI Study | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2009 | 290 |
| 26 | Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization | Nature Genetics | 2014 | 281 |
| 27 | Inflammatory Markers and Incident Mobility Limitation in the Elderly | Journal of the American Geriatrics Society | 2004 | 276 |
| 28 | The Effect of Social Engagement on Incident Dementia | American Journal of Epidemiology | 2006 | 268 |
| 29 | Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition Study | PLoS ONE | 2011 | 268 |
| 30 | The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts | PLoS Genetics | 2007 | 249 |
| 31 | A Prospective Study of Frailty in Nephrology-Referred Patients With CKD | American Journal of Kidney Diseases | 2012 | 246 |
| 32 | Association of executive function and performance of dual-task physical tests among older adults: analyses from the InChianti study | Age and Ageing | 2006 | 239 |
| 33 | Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing | Aging Cell | 2011 | 230 |
| 34 | Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations | American Journal of Human Genetics | 2009 | 225 |
| 35 | Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci | Nature Genetics | 2016 | 223 |
| 36 | Demonstrating the case that AD is a vascular disease: epidemiologic evidence | Ageing Research Reviews | 2002 | 206 |
| 37 | Does the Amount of Fat Mass Predict Age-Related Loss of Lean Mass, Muscle Strength, and Muscle Quality in Older Adults? | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2011 | 205 |
| 38 | Comorbidities and Impairments Explaining the Association Between Diabetes and Lower Extremity Disability: The Women's Health and Aging Study | Diabetes Care | 2002 | 199 |
| 39 | Cerebral microbleeds, retinopathy, and dementia | Neurology | 2010 | 197 |
| 40 | Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque | Nature Genetics | 2011 | 191 |
| 41 | Proinflammatory state and circulating erythropoietin in persons with and without anemia | American Journal of Medicine | 2005 | 185 |
| 42 | Age and comorbidity impact surgical therapy in older bladder carcinoma patients | Cancer | 2005 | 184 |
| 43 | Metabolic Syndrome and the Risk of Cardiovascular Disease in Older Adults | Journal of the American College of Cardiology | 2006 | 179 |
| 44 | Diabetes Is Associated Independently of Body Composition With BMD and Bone Volume in Older White and Black Men and Women: The Health, Aging, and Body Composition Study | Journal of Bone and Mineral Research | 2004 | 174 |
| 45 | One- and two-year change in body composition as measured by DXA in a population-based cohort of older men and women | Journal of Applied Physiology | 2003 | 173 |
| 46 | Waist Circumference and Mortality | American Journal of Epidemiology | 2008 | 173 |
| 47 | Reducing the Risk of Dementia | Stroke | 2006 | 166 |
| 48 | Frailty and risk for heart failure in older adults: The health, aging, and body composition study | American Heart Journal | 2013 | 155 |
| 49 | The Impact of Functional Status on Life Expectancy in Older Persons | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2010 | 154 |
| 50 | Gait Speed Predicts Decline in Attention and Psychomotor Speed in Older Adults: The Health Aging and Body Composition Study | Neuroepidemiology | 2007 | 151 |
