| # | Title | Journal | Year | Citations |
|---|
| 1 | Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6 | Science | 2009 | 2,295 |
| 2 | Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease | Nature Medicine | 2003 | 1,244 |
| 3 | Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe | Human Brain Mapping | 2003 | 1,040 |
| 4 | Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells | Blood | 2005 | 1,026 |
| 5 | In-vivo measurement of activated microglia in dementia | Lancet, The | 2001 | 983 |
| 6 | The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita | Nature | 2001 | 902 |
| 7 | Chronic Myeloid Leukemia — Advances in Biology and New Approaches to Treatment | New England Journal of Medicine | 2003 | 875 |
| 8 | Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL‐PET study | Annals of Neurology | 2003 | 820 |
| 9 | Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis | Brain | 2011 | 685 |
| 10 | TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT) | Respiratory Research | 2005 | 655 |
| 11 | Tim-3 inhibits T helper type 1–mediated auto- and alloimmune responses and promotes immunological tolerance | Nature Immunology | 2003 | 630 |
| 12 | Response to Imatinib Mesylate in Patients with Chronic Myeloproliferative Diseases with Rearrangements of the Platelet-Derived Growth Factor Receptor Beta | New England Journal of Medicine | 2002 | 623 |
| 13 | Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial | Lancet, The | 2005 | 601 |
| 14 | Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus | Nature Genetics | 2007 | 590 |
| 15 | Kisspeptin-54 Stimulates the Hypothalamic-Pituitary Gonadal Axis in Human Males | Journal of Clinical Endocrinology and Metabolism | 2005 | 574 |
| 16 | The genetics of human obesity | Nature Reviews Genetics | 2005 | 546 |
| 17 | Origin and timing of brain lesions in term infants with neonatal encephalopathy | Lancet, The | 2003 | 544 |
| 18 | Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis | BMJ: British Medical Journal | 2002 | 518 |
| 19 | Mechanisms of Disease: genetic causes of familial hypercholesterolemia | Nature Clinical Practice Cardiovascular Medicine | 2007 | 479 |
| 20 | Repeatability of published microarray gene expression analyses | Nature Genetics | 2009 | 477 |
| 21 | Parkinson's disease symptoms: The patient's perspective | Movement Disorders | 2010 | 464 |
| 22 | Proinflammatory Activation of Macrophages by Basic Calcium Phosphate Crystals via Protein Kinase C and MAP Kinase Pathways | Circulation Research | 2005 | 450 |
| 23 | Compulsive drug use linked to sensitized ventral striatal dopamine transmission | Annals of Neurology | 2006 | 435 |
| 24 | Hemoglobin Scavenger Receptor CD163 Mediates Interleukin-10 Release and Heme Oxygenase-1 Synthesis | Circulation Research | 2004 | 425 |
| 25 | Dyskinesias following neural transplantation in Parkinson's disease | Nature Neuroscience | 2002 | 424 |
| 26 | Appetite control | Journal of Endocrinology | 2005 | 419 |
| 27 | Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease | Hepatology | 2002 | 407 |
| 28 | Microglial activation correlates with severity in Huntington disease | Neurology | 2006 | 399 |
| 29 | Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling | Nature Reviews Immunology | 2003 | 335 |
| 30 | Validation of the freezing of gait questionnaire in patients with Parkinson's disease | Movement Disorders | 2009 | 332 |
| 31 | Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions | Molecular and Cellular Endocrinology | 2003 | 327 |
| 32 | Muscle satellite cells | International Journal of Biochemistry and Cell Biology | 2003 | 323 |
| 33 | Exploring the origins of grey matter damage in multiple sclerosis | Nature Reviews Neuroscience | 2015 | 317 |
| 34 | Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation | Nature Biotechnology | 2004 | 313 |
| 35 | Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis | Brain | 2012 | 310 |
| 36 | Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial | Lancet Oncology, The | 2020 | 306 |
| 37 | Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population | Journal of Hypertension | 2003 | 305 |
| 38 | Hormonal Regulation of Food Intake | Physiological Reviews | 2005 | 301 |
| 39 | A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy | European Heart Journal | 2011 | 292 |
| 40 | Growth factor expression and function in the human and mouse preimplantation embryo | Journal of Endocrinology | 2002 | 285 |
| 41 | Clinical features and outcome of patients with both ANCA and anti-GBM antibodies | Kidney International | 2004 | 284 |
| 42 | Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage Phenotype | American Journal of Pathology | 2009 | 284 |
| 43 | Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours | Brain | 2011 | 283 |
| 44 | A new locus for hereditary haemorrhagic telangiectasia (HHT3) maps to chromosome 5 | Journal of Medical Genetics | 2005 | 280 |
| 45 | Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): a view from the 21st century | Postgraduate Medical Journal | 2003 | 277 |
| 46 | Primary determinants of ischaemic stroke/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia | Thorax | 2008 | 274 |
| 47 | Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson’s Patients with Neural Transplants | Science Translational Medicine | 2010 | 272 |
| 48 | A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk | Nature | 2010 | 271 |
| 49 | Association between aplastic anaemia and mutations in telomerase RNA | Lancet, The | 2002 | 261 |
| 50 | Glial cell line–derived neurotrophic factor induces neuronal sprouting in human brain | Nature Medicine | 2005 | 256 |
