| # | Title | Journal | Year | Citations |
|---|
| 1 | Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease | New England Journal of Medicine | 2006 | 1,536 |
| 2 | Effects of Fondaparinux on Mortality and Reinfarction in Patients With Acute ST-Segment Elevation Myocardial Infarction: The OASIS-6 Randomized Trial | JAMA - Journal of the American Medical Association | 2006 | 830 |
| 3 | RANDOMISED COMPARISON OF TWO INTENSITIES OF ORAL ANTICOAGULANT THERAPY AFTER TISSUE HEART VALVE REPLACEMENT | Lancet, The | 1988 | 282 |
| 4 | Beyond Unfractionated Heparin and Warfarin | Circulation | 2007 | 202 |
| 5 | Canadian clinical practice guidelines for acute and chronic rhinosinusitis | Allergy, Asthma and Clinical Immunology | 2011 | 153 |
| 6 | Obesity, hypertension and insulin resistance | Acta Diabetologica | 2005 | 109 |
| 7 | A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery | Journal of Thrombosis and Haemostasis | 2007 | 107 |
| 8 | Influence of Sibutramine on blood pressure: evidence from placebo-controlled trials | International Journal of Obesity | 2005 | 80 |
| 9 | Seasonal Variation in Leisure-time Physical Activity Among Canadians | Canadian Journal of Public Health | 2007 | 76 |
| 10 | A Family-based Intervention to Promote Healthy Lifestyles in an Aboriginal Community in Canada | Canadian Journal of Public Health | 2007 | 72 |
| 11 | Recognition and management of overweight and obesity in primary care in Germany | International Journal of Obesity | 2004 | 70 |
| 12 | Obesity and cardiovascular risk | Growth Hormone and IGF Research | 2003 | 64 |
| 13 | Incidence of thrombosis in perioperative and non-operative myocardial infarction | British Journal of Anaesthesia | 2018 | 64 |
| 14 | Prevention of venous thromboembolism with an oral factor Xa inhibitor, YM150, after total hip arthroplasty. A dose finding study (ONYX‐2) | Journal of Thrombosis and Haemostasis | 2010 | 59 |
| 15 | The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol | Systematic Reviews | 2014 | 49 |
| 16 | New antithrombotic agents—insights from clinical trials | Nature Reviews Cardiology | 2010 | 45 |
| 17 | Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction | American Heart Journal | 2004 | 42 |
| 18 | Clinical Outcomes of Treatment by Percutaneous Coronary Intervention Versus Coronary Artery Bypass Graft Surgery in Patients With Chronic Kidney Disease Undergoing Index Revascularization in Ontario | Circulation: Cardiovascular Interventions | 2015 | 42 |
| 19 | Management Strategies for a Better Outcome in Unstable Coronary Artery Disease | Clinical Cardiology | 1998 | 40 |
| 20 | Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients | Journal of Hypertension | 2005 | 39 |
| 21 | Plasma betathromboglobulin and serum fragment E in acute partial stroke | British Journal of Haematology | 1982 | 36 |
| 22 | Metabolic Profile and Exercise Capacity Outcomes | Journal of Cardiopulmonary Rehabilitation and Prevention | 2004 | 35 |
| 23 | A Prospective Study to Investigate Predictors of Relapse among Patients with Opioid Use Disorder Treated with Methadone | Substance Abuse: Research and Treatment | 2016 | 34 |
| 24 | Measurements of Cardiac Output in Seriously Ill Patients Using a CO2 Rebreathing Method | Chest | 1978 | 33 |
| 25 | Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria | Trials | 2015 | 33 |
| 26 | Efficacy and safety of ablation for people with non-paroxysmal atrial fibrillation | The Cochrane Library | 2016 | 33 |
| 27 | The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy | Addiction Science & Clinical Practice | 2017 | 33 |
| 28 | Plasma beta-thromboglobulin: differentiation between intravascular and extravascular platelet destruction | Blood | 1979 | 32 |
| 29 | Neutralization of Heparin Activity | Handbook of Experimental Pharmacology | 2012 | 31 |
| 30 | Functional capacity in patients with congestive heart failure | Journal of Cardiac Failure | 2000 | 29 |
| 31 | Obesity and the heart: redefinition of the relationship | Obesity Reviews | 2007 | 26 |
| 32 | Validity of the US Behavioral Risk Factor Surveillance System's health related quality of life survey tool in a group of older Canadians | Chronic Diseases in Canada | 2001 | 26 |
| 33 | Venous Thromboembolism Pharmacy Intervention Management Program With an Active, Multifaceted Approach Reduces Preventable Venous Thromboembolism and Increases Appropriate Prophylaxis | Clinical and Applied Thrombosis/Hemostasis | 2012 | 21 |
| 34 | Colchicine for Prevention of Perioperative Atrial Fibrillation in patients undergoing lung resection surgery: a pilot randomized controlled study | European Journal of Cardio-thoracic Surgery | 2018 | 21 |
| 35 | Endoscopic versus open microvascular decompression for trigeminal neuralgia: a systematic review and comparative meta-analysis | Journal of Neurosurgery | 2019 | 19 |
| 36 | Challenges in the conduct and interpretation of phase II (pilot) randomized trials | American Heart Journal | 2000 | 18 |
| 37 | Risk assessment of venous thromboembolism in hospitalized medical patients | Current Opinion in Pulmonary Medicine | 2010 | 17 |
| 38 | Screening for Cognitive Impairment in a Stroke Prevention Clinic Using the MoCA | Canadian Journal of Neurological Sciences | 2013 | 17 |
| 39 | Different strategies for pharmacological thromboprophylaxis for lower-limb immobilisation after injury: systematic review and economic evaluation | Health Technology Assessment | 2019 | 17 |
| 40 | Value of the Gram-Stained Urethral Smear in the Management of Men with Urethritis | Sexually Transmitted Diseases | 1988 | 16 |
| 41 | Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation | Neuropsychiatric Disease and Treatment | 2014 | 16 |
| 42 | To bridge or not to bridge: that is the question. The argument FOR bridging therapy in patients on oral anticoagulants requiring temporary interruption for elective procedures | Journal of Thrombosis and Thrombolysis | 2010 | 15 |
| 43 | Antihypertensive Effect of Irbesartan and Predictors of Response in Obesity-Associated Hypertension | Clinical Drug Investigation | 2005 | 13 |
| 44 | Patterns of medical therapy in patients with peripheral artery disease in a tertiary care centre in Canada | Canadian Journal of Cardiology | 2007 | 13 |
| 45 | Stroke Prevention in Atrial Fibrillation | Medical Clinics of North America | 2019 | 12 |
| 46 | Clinical Practice Guidelines in Cardio-Oncology | Heart Failure Clinics | 2022 | 12 |
| 47 | Laboratory testing for VITT antibodies | Seminars in Hematology | 2022 | 11 |
| 48 | Mandatory contrast-enhanced venography to detect deep-vein thrombosis (DVT) in studies of DVT prophylaxis: upsides and downsides | Thrombosis and Haemostasis | 2014 | 10 |
| 49 | A Systematic Review of the Risk of Motor Vehicle Collision in Patients With Syncope | Canadian Journal of Cardiology | 2021 | 9 |
| 50 | Hemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese men | Journal of Hypertension | 2006 | 8 |
