| # | Title | Journal | Year | Citations |
|---|
| 1 | Mesenchyme Forkhead 1 ( FOXC2 ) plays a key role in metastasis and is associated with aggressive basal-like breast cancers | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 517 |
| 2 | De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy | Nature Genetics | 2008 | 498 |
| 3 | Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease | Clinical and Experimental Nephrology | 2007 | 488 |
| 4 | Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours | Nature Genetics | 1996 | 429 |
| 5 | Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer | Nature Genetics | 2008 | 359 |
| 6 | T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation | Neurology | 2008 | 303 |
| 7 | The Finger-Tapping Test | Archives of Neurology | 1990 | 244 |
| 8 | Influence of CYP2C19 Pharmacogenetic Polymorphism on Proton Pump Inhibitor-based Therapies | Drug Metabolism and Pharmacokinetics | 2005 | 215 |
| 9 | Detection and Characterization of Focal Liver Lesions | Investigative Radiology | 2010 | 212 |
| 10 | The Hair Follicle and Immune Privilege | Journal of Investigative Dermatology Symposium Proceedings | 2003 | 204 |
| 11 | Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice | Journal of Clinical Investigation | 2011 | 195 |
| 12 | Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway | Arteriosclerosis, Thrombosis, and Vascular Biology | 2010 | 185 |
| 13 | Single- and multiple-dose pharmacokinetics of AM-1155, a new 6-fluoro-8-methoxy quinolone, in humans | Antimicrobial Agents and Chemotherapy | 1995 | 179 |
| 14 | A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus | Journal of Gastroenterology | 2006 | 173 |
| 15 | Long-term quality-of-life comparison of total gastrectomy and proximal gastrectomy by Postgastrectomy Syndrome Assessment Scale (PGSAS-45): a nationwide multi-institutional study | Gastric Cancer | 2015 | 166 |
| 16 | Role of biologic glue repair of proximal aortic dissection in the development of early and midterm redissection of the aortic root | Annals of Thoracic Surgery | 2001 | 164 |
| 17 | A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RARα transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study | Blood | 2007 | 158 |
| 18 | CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium | Nature Genetics | 2012 | 157 |
| 19 | 18F-FDG PET in the detection of extrahepatic metastases from hepatocellular carcinoma | Journal of Gastroenterology | 2004 | 156 |
| 20 | Cigarette smokers self-administer intravenous nicotine | Pharmacology Biochemistry and Behavior | 1983 | 154 |
| 21 | Hereditary deficiency of lactate dehydrogenase M-subunit | Clinica Chimica Acta | 1980 | 153 |
| 22 | Tissue Factor Expression and Fibrin Deposition in the Lungs of Patients with Idiopathic Pulmonary Fibrosis and Systemic Sclerosis | American Journal of Respiratory and Critical Care Medicine | 1997 | 140 |
| 23 | Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin | Pharmacogenetics and Genomics | 2001 | 139 |
| 24 | Antithrombotic Effect of Geniposide and Genipin in the Mouse Thrombosis Model | Planta Medica | 2001 | 136 |
| 25 | Metacarpal bone mass in normal and osteoporotic Japanese women using computed X-ray densitometry | Calcified Tissue International | 1994 | 133 |
| 26 | Chronic kidney disease perspectives in Japan and the importance of urinalysis screening | Clinical and Experimental Nephrology | 2008 | 131 |
| 27 | Acute exacerbation in rheumatoid arthritis-associated interstitial lung disease: a retrospective case control study | BMJ Open | 2013 | 131 |
| 28 | Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A HuGE-GSEC Review | American Journal of Epidemiology | 2006 | 130 |
| 29 | Deficiency in p57Kip2 expression induces preeclampsia-like symptoms in mice | Molecular Human Reproduction | 2002 | 128 |
| 30 | Place of Death and the Differences in Patient Quality of Death and Dying and Caregiver Burden | Journal of Clinical Oncology | 2015 | 128 |
| 31 | Bone mineral density of the spine in normal Japanese subjects using dual-energy X-ray absorptiometry: Effect of obesity and menopausal status | Calcified Tissue International | 1991 | 127 |
| 32 | Visualization of Volatile Substances in Different Organelles with an Atmospheric-Pressure Mass Microscope | Analytical Chemistry | 2009 | 127 |
| 33 | Formation of acetaldehyde-derived DNA adducts due to alcohol exposure | Chemico-Biological Interactions | 2010 | 127 |
| 34 | Guidelines for the use of biochemical markers of bone turnover in osteoporosis (2004) | Journal of Bone and Mineral Metabolism | 2005 | 120 |
| 35 | GABA-A Receptors Regulate Neocortical Neuronal Migration In Vitro and In Vivo | Cerebral Cortex | 2006 | 118 |
| 36 | Quantitative autistic traits ascertained in a national survey of 22 529 Japanese schoolchildren | Acta Psychiatrica Scandinavica | 2013 | 117 |
| 37 | Behavioral and endocrinological evaluation of music therapy for elderly patients with dementia | Australian Journal of Cancer Nursing | 2004 | 116 |
| 38 | Synergistic activation of brain adenylate cyclase by calmodulin, and either GTP or catecholamines including dopamine | Brain Research | 1990 | 113 |
| 39 | Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients | Human Mutation | 1992 | 113 |
| 40 | Inhibitory Effect of MCI-186, a Free Radical Scavenger, on Cerebral Ischemia Following Rat Middle Cerebral Artery Occlusion | General Pharmacology | 1998 | 112 |
| 41 | Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene | EMBO Journal | 1999 | 109 |
| 42 | Optimization of Codon Usage of Plasmid DNA Vaccine Is Required for the Effective MHC Class I-Restricted T Cell Responses Against an Intracellular Bacterium | Journal of Immunology | 1998 | 108 |
| 43 | Relationships between Euglobulin Clot Lysis Time and the Plasma Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 | Thrombosis and Haemostasis | 1990 | 106 |
| 44 | Malfunction of Respiratory-Related Neuronal Activity in Na+, K+-ATPase 2 Subunit-Deficient Mice Is Attributable to Abnormal Cl- Homeostasis in Brainstem Neurons | Journal of Neuroscience | 2004 | 105 |
| 45 | Neuroaxonal Dystrophy in Calcium-Independent Phospholipase A2β Deficiency Results from Insufficient Remodeling and Degeneration of Mitochondrial and Presynaptic Membranes | Journal of Neuroscience | 2011 | 105 |
| 46 | CD59 blocks not only the insertion of C9 into MAC but inhibits ion channel formation by homologous C5b‐8 as well as C5b‐9 | Journal of Physiology | 2002 | 104 |
| 47 | SomaticNLRP3mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes | Annals of the Rheumatic Diseases | 2015 | 104 |
| 48 | Paradoxical ATP Elevation in Ischemic Penumbra Revealed by Quantitative Imaging Mass Spectrometry | Antioxidants and Redox Signaling | 2010 | 102 |
| 49 | Photochemically induced thrombosis model in rat femoral artery and evaluation of effects of heparin and tissue-type plasminogen activator with use of this model | Journal of Pharmacological Methods | 1991 | 101 |
| 50 | Evaluation of the combination of a tissue-type plasminogen activator, SUN9216, and a thromboxane A2 receptor antagonist, vapiprost, in a rat middle cerebral artery thrombosis model. | Stroke | 1993 | 99 |
