| # | Title | Journal | Year | Citations |
|---|
| 1 | The size and burden of mental disorders and other disorders of the brain in Europe 2010 | European Neuropsychopharmacology | 2011 | 2,930 |
| 2 | Large recurrent microdeletions associated with schizophrenia | Nature | 2008 | 1,619 |
| 3 | Common variants conferring risk of schizophrenia | Nature | 2009 | 1,572 |
| 4 | The economic cost of brain disorders in Europe | European Journal of Neurology | 2012 | 1,163 |
| 5 | Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine | New England Journal of Medicine | 2004 | 1,118 |
| 6 | Cgrp May Play A Causative Role in Migraine | Cephalalgia | 2002 | 852 |
| 7 | New Appendix Criteria Open for a Broader Concept of Chronic Migraine | Cephalalgia | 2006 | 846 |
| 8 | Cost of disorders of the brain in Europe | European Journal of Neurology | 2005 | 714 |
| 9 | Guidelines for Controlled Trials of Drugs in Migraine: Second Edition | Cephalalgia | 2000 | 615 |
| 10 | Migraine With Aura and Migraine Without Aura: An Epidemiological Study | Cephalalgia | 1992 | 535 |
| 11 | Epidemiology and comorbidity of headache | Lancet Neurology, The | 2008 | 523 |
| 12 | The International Classification of Headache Disorders: 2nd edition | Lancet Neurology, The | 2003 | 496 |
| 13 | Central Sensitization in Tension-Type Headache—Possible Pathophysiological Mechanisms | Cephalalgia | 2000 | 469 |
| 14 | Origin of pain in migraine: evidence for peripheral sensitisation | Lancet Neurology, The | 2009 | 458 |
| 15 | Triptans in Migraine | Drugs | 2000 | 442 |
| 16 | A nosographic analysis of the migraine aura in a general population | Brain | 1996 | 425 |
| 17 | Migraine and tension-type headache in a general population: precipitating factors, female hormones, sleep pattern and relation to lifestyle | Pain | 1993 | 413 |
| 18 | Prevalence and Sex-Ratio of the Subtypes of Migraine | International Journal of Epidemiology | 1995 | 400 |
| 19 | PACAP38 induces migraine-like attacks in patients with migraine without aura | Brain | 2009 | 360 |
| 20 | Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial | Lancet Neurology, The | 2014 | 333 |
| 21 | Ergotamine in the acute treatment of migraine: A review and European consensus | Brain | 2000 | 329 |
| 22 | EFNS guideline on the treatment of tension‐type headache – Report of an EFNS task force | European Journal of Neurology | 2010 | 328 |
| 23 | Understanding idiopathic intracranial hypertension: mechanisms, management, and future directions | Lancet Neurology, The | 2016 | 321 |
| 24 | Increased familial risk and evidence of genetic factor in migraine | BMJ: British Medical Journal | 1995 | 312 |
| 25 | Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study | Cephalalgia | 2013 | 308 |
| 26 | Migraine Without Aura and Migraine with Aura Are Distinct Clinical Entities: A Study of Four Hundred and Eighty-Four Male and Female Migraineurs From the General Population | Cephalalgia | 1996 | 303 |
| 27 | A nitric oxide donor (nitroglycerin) triggers genuine migraine attacks | European Journal of Neurology | 1994 | 281 |
| 28 | Migraine can be induced by sildenafil without changes in middle cerebral artery diameter | Brain | 2003 | 272 |
| 29 | Guidelines for Controlled Trials of Prophylactic Treatment of Chronic Migraine in Adults | Cephalalgia | 2008 | 270 |
| 30 | Evidence for a vascular factor in migraine | Annals of Neurology | 2011 | 252 |
| 31 | Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study | Multiple Sclerosis Journal | 2015 | 249 |
| 32 | The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache | Multiple Sclerosis Journal | 2008 | 243 |
| 33 | Nitric oxide is a key molecule in migraine and other vascular headaches | Trends in Pharmacological Sciences | 1994 | 239 |
| 34 | CCR1+/CCR5+ Mononuclear Phagocytes Accumulate in the Central Nervous System of Patients with Multiple Sclerosis | American Journal of Pathology | 2001 | 238 |
| 35 | Nitric oxide synthase inhibition in migraine | Lancet, The | 1997 | 237 |
| 36 | Prevalence of neck pain in migraine and tension-type headache: A population study | Cephalalgia | 2015 | 235 |
| 37 | Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system | Journal of Neuroimmunology | 2002 | 231 |
| 38 | Trigeminal Neuralgia – A Prospective Systematic Study of Clinical Characteristics in 158 Patients | Headache | 2014 | 226 |
| 39 | Vasoactive Intestinal Peptide Causes Marked Cephalic Vasodilation, but does not Induce Migraine | Cephalalgia | 2008 | 221 |
| 40 | The Nitric Oxide Hypothesis of Migraine and Other Vascular Headaches | Cephalalgia | 1995 | 211 |
| 41 | Evidence of a genetic factor in migraine with aura: A population-based Danish twin study | Annals of Neurology | 1999 | 210 |
| 42 | A population‐based study of familial hemiplegic migraine suggests revised diagnostic criteria | Brain | 2002 | 208 |
| 43 | Decreased Pain Detection and Tolerance Thresholds in Chronic Tension-Type Headache | Archives of Neurology | 1996 | 207 |
| 44 | A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. | Journal of Neurology, Neurosurgery and Psychiatry | 1996 | 203 |
| 45 | Muscular Factors are of Importance in Tension-Type Headache | Headache | 1998 | 194 |
| 46 | Significance of neurovascular contact in classical trigeminal neuralgia | Brain | 2015 | 191 |
| 47 | Abnormal blood–brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI | NeuroImage: Clinical | 2014 | 180 |
| 48 | Qualitatively altered nociception in chronic myofascial pain | Pain | 1996 | 179 |
| 49 | Glyceryl Trinitrate Induces Attacks of Migraine Without Aura in Sufferers of Migraine with Aura | Cephalalgia | 1999 | 179 |
| 50 | Headache disorders are third cause of disability worldwide | Journal of Headache and Pain | 2015 | 179 |
