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Top Articles

#TitleJournalYearCitations
1Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphateNature19961,443
2Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular functionTrends in Pharmacological Sciences20061,237
3The Universal Protein Resource (UniProt): an expanding universe of protein informationNucleic Acids Research2006961
4Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogensNature1993877
5Sphingolipid metabolism and cell growth regulationFASEB Journal1996691
6Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.Journal of Cell Biology1991615
7Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 IsoformJournal of Biological Chemistry2000605
8Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and PathophysiologyToxicology and Applied Pharmacology1997604
9Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and SurvivalJournal of Cell Biology1999494
10Molecular Cloning and Functional Characterization of Murine Sphingosine KinaseJournal of Biological Chemistry1998492
11Signal transduction through lipid second messengersCurrent Opinion in Cell Biology1996488
12Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and SurvivalJournal of Cell Biology1998464
13Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell MotilityScience2001415
14The Protein Information ResourceNucleic Acids Research2003385
15Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthmaFASEB Journal2001305
16The Initiator Function of DnaA Protein Is Negatively Regulated by the Sliding Clamp of the E. coli Chromosomal ReplicaseCell1998292
17Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and DifferentiationJournal of Neuroscience1997269
18Sphingosine-1-phosphate: signaling inside and outFEBS Letters2000253
19Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.Journal of Biological Chemistry1994252
20In search of rat stem Leydig cells: Identification, isolation, and lineage-specific developmentProceedings of the National Academy of Sciences of the United States of America2006246
21Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T LymphocytesJournal of Biological Chemistry1998243
22N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C:  Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide†Biochemistry1998224
23Glycosylphosphatidylinositol Anchors of Plasmodium falciparumJournal of Experimental Medicine2000220
24Peripheral-Type Benzodiazepine Receptor-Mediated Action of Steroidogenic Acute Regulatory Protein on Cholesterol Entry into Leydig Cell MitochondriaMolecular Endocrinology2005218
25Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathwayJournal of Biological Chemistry1994218
26Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.Journal of Biological Chemistry1990216
27A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative StressJournal of Biological Chemistry1995213
28Sphingolipid metabolites: Members of a new class of lipid second messengersJournal of Membrane Biology1995210
29Sphingosine-1-Phosphate in Cell Growth and Cell DeathaAnnals of the New York Academy of Sciences1998209
30Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disordersNeuroscience2006208
31Purification and Characterization of Rat Kidney Sphingosine KinaseJournal of Biological Chemistry1998207
32Sphingosine Kinase Type 1 Promotes Estrogen-Dependent Tumorigenesis of Breast Cancer MCF-7 CellsExperimental Cell Research2002205
33Protein sequence databasesCurrent Opinion in Chemical Biology2004201
34PIRSF: family classification system at the Protein Information ResourceNucleic Acids Research2004193
35Functions of a new family of sphingosine-1-phosphate receptorsBiochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids2000184
36Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathwayJournal of Biological Chemistry1990180
37Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cellsJournal of Neurochemistry2001179
38Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent MechanismJournal of Biological Chemistry1995177
39Zn2+ Promotes the Self-Association of Human Immunodeficiency Virus Type-1 Integrase in VitroBiochemistry1997177
40Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6Blood2000176
41Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218Journal of Biological Chemistry1999171
42Sphingosine 1-phosphate: a prototype of a new class of second messengersJournal of Leukocyte Biology1999164
43EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migrationFASEB Journal2001161
44Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosisJournal of Cell Biology2002160
45Involvement of Sphingosine in Mitochondria-dependent Fas-induced Apoptosis of Type II Jurkat T CellsJournal of Biological Chemistry2000159
46Characterization of Proteoglycans of Human Placenta and Identification of Unique Chondroitin Sulfate Proteoglycans of the Intervillous Spaces That Mediate the Adherence ofPlasmodium falciparum-infected Erythrocytes to the PlacentaJournal of Biological Chemistry2000157
47Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-PhosphateJournal of Biological Chemistry1995154
48Sphingosine kinase: a mediator of vital cellular functionsProstaglandins and Other Lipid Mediators2001149
49Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activationJournal of Biological Chemistry1992142
50Gravidity-Dependent Production of Antibodies That Inhibit Binding of Plasmodium falciparum -Infected Erythrocytes to Placental Chondroitin Sulfate Proteoglycan during PregnancyInfection and Immunity2001141