# | Title | Journal | Year | Citations |
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1 | Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate | Nature | 1996 | 1,443 |
2 | Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function | Trends in Pharmacological Sciences | 2006 | 1,237 |
3 | The Universal Protein Resource (UniProt): an expanding universe of protein information | Nucleic Acids Research | 2006 | 961 |
4 | Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens | Nature | 1993 | 877 |
5 | Sphingolipid metabolism and cell growth regulation | FASEB Journal | 1996 | 691 |
6 | Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. | Journal of Cell Biology | 1991 | 615 |
7 | Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform | Journal of Biological Chemistry | 2000 | 605 |
8 | Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology | Toxicology and Applied Pharmacology | 1997 | 604 |
9 | Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival | Journal of Cell Biology | 1999 | 494 |
10 | Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase | Journal of Biological Chemistry | 1998 | 492 |
11 | Signal transduction through lipid second messengers | Current Opinion in Cell Biology | 1996 | 488 |
12 | Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival | Journal of Cell Biology | 1998 | 464 |
13 | Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility | Science | 2001 | 415 |
14 | The Protein Information Resource | Nucleic Acids Research | 2003 | 385 |
15 | Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma | FASEB Journal | 2001 | 305 |
16 | The Initiator Function of DnaA Protein Is Negatively Regulated by the Sliding Clamp of the E. coli Chromosomal Replicase | Cell | 1998 | 292 |
17 | Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation | Journal of Neuroscience | 1997 | 269 |
18 | Sphingosine-1-phosphate: signaling inside and out | FEBS Letters | 2000 | 253 |
19 | Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. | Journal of Biological Chemistry | 1994 | 252 |
20 | In search of rat stem Leydig cells: Identification, isolation, and lineage-specific development | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 246 |
21 | Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes | Journal of Biological Chemistry | 1998 | 243 |
22 | N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide† | Biochemistry | 1998 | 224 |
23 | Glycosylphosphatidylinositol Anchors of Plasmodium falciparum | Journal of Experimental Medicine | 2000 | 220 |
24 | Peripheral-Type Benzodiazepine Receptor-Mediated Action of Steroidogenic Acute Regulatory Protein on Cholesterol Entry into Leydig Cell Mitochondria | Molecular Endocrinology | 2005 | 218 |
25 | Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway | Journal of Biological Chemistry | 1994 | 218 |
26 | Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway. | Journal of Biological Chemistry | 1990 | 216 |
27 | A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress | Journal of Biological Chemistry | 1995 | 213 |
28 | Sphingolipid metabolites: Members of a new class of lipid second messengers | Journal of Membrane Biology | 1995 | 210 |
29 | Sphingosine-1-Phosphate in Cell Growth and Cell Deatha | Annals of the New York Academy of Sciences | 1998 | 209 |
30 | Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders | Neuroscience | 2006 | 208 |
31 | Purification and Characterization of Rat Kidney Sphingosine Kinase | Journal of Biological Chemistry | 1998 | 207 |
32 | Sphingosine Kinase Type 1 Promotes Estrogen-Dependent Tumorigenesis of Breast Cancer MCF-7 Cells | Experimental Cell Research | 2002 | 205 |
33 | Protein sequence databases | Current Opinion in Chemical Biology | 2004 | 201 |
34 | PIRSF: family classification system at the Protein Information Resource | Nucleic Acids Research | 2004 | 193 |
35 | Functions of a new family of sphingosine-1-phosphate receptors | Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids | 2000 | 184 |
36 | Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway | Journal of Biological Chemistry | 1990 | 180 |
37 | Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells | Journal of Neurochemistry | 2001 | 179 |
38 | Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism | Journal of Biological Chemistry | 1995 | 177 |
39 | Zn2+ Promotes the Self-Association of Human Immunodeficiency Virus Type-1 Integrase in Vitro | Biochemistry | 1997 | 177 |
40 | Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6 | Blood | 2000 | 176 |
41 | Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218 | Journal of Biological Chemistry | 1999 | 171 |
42 | Sphingosine 1-phosphate: a prototype of a new class of second messengers | Journal of Leukocyte Biology | 1999 | 164 |
43 | EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration | FASEB Journal | 2001 | 161 |
44 | Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis | Journal of Cell Biology | 2002 | 160 |
45 | Involvement of Sphingosine in Mitochondria-dependent Fas-induced Apoptosis of Type II Jurkat T Cells | Journal of Biological Chemistry | 2000 | 159 |
46 | Characterization of Proteoglycans of Human Placenta and Identification of Unique Chondroitin Sulfate Proteoglycans of the Intervillous Spaces That Mediate the Adherence ofPlasmodium falciparum-infected Erythrocytes to the Placenta | Journal of Biological Chemistry | 2000 | 157 |
47 | Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-Phosphate | Journal of Biological Chemistry | 1995 | 154 |
48 | Sphingosine kinase: a mediator of vital cellular functions | Prostaglandins and Other Lipid Mediators | 2001 | 149 |
49 | Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation | Journal of Biological Chemistry | 1992 | 142 |
50 | Gravidity-Dependent Production of Antibodies That Inhibit Binding of Plasmodium falciparum -Infected Erythrocytes to Placental Chondroitin Sulfate Proteoglycan during Pregnancy | Infection and Immunity | 2001 | 141 |