| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 2 | Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis | Lancet, The | 2019 | 1,050 |
| 3 | Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 1,032 |
| 4 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 700 |
| 5 | Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV | Nature | 2021 | 475 |
| 6 | A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol | Nature | 2020 | 276 |
| 7 | Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak | Annals of Intensive Care | 2020 | 239 |
| 8 | Tissue-specific tumorigenesis: context matters | Nature Reviews Cancer | 2017 | 234 |
| 9 | Minimal phenotyping yields genome-wide association signals of low specificity for major depression | Nature Genetics | 2020 | 207 |
| 10 | The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity | Cell Reports | 2017 | 202 |
| 11 | COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients | Infection | 2020 | 191 |
| 12 | Human NLRP1 is a sensor for double-stranded RNA | Science | 2021 | 191 |
| 13 | E-PSMA: the EANM standardized reporting guidelines v1.0 for PSMA-PET | European Journal of Nuclear Medicine and Molecular Imaging | 2021 | 188 |
| 14 | Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis | Lancet Psychiatry,the | 2019 | 184 |
| 15 | The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes | Nature Communications | 2018 | 181 |
| 16 | Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity | Nature Neuroscience | 2019 | 181 |
| 17 | Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis | Lancet Psychiatry,the | 2020 | 176 |
| 18 | Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine | Journal of Nuclear Medicine | 2019 | 172 |
| 19 | Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors | European Journal of Preventive Cardiology | 2020 | 172 |
| 20 | Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders | Brain | 2020 | 158 |
| 21 | An orthogonal proteomic survey uncovers novel Zika virus host factors | Nature | 2018 | 156 |
| 22 | DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis | Nature Communications | 2018 | 147 |
| 23 | Four-repeat tauopathies | Progress in Neurobiology | 2019 | 141 |
| 24 | A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape | Nature Immunology | 2019 | 139 |
| 25 | Monogenic variants in dystonia: an exome-wide sequencing study | Lancet Neurology, The | 2020 | 139 |
| 26 | Environmental interventions to reduce the consumption of sugar-sweetened beverages and their effects on health | The Cochrane Library | 2019 | 138 |
| 27 | Diagnostic Accuracy of 68Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node Dissection | JAMA Oncology | 2021 | 138 |
| 28 | CARD–BCL-10–MALT1 signalling in protective and pathological immunity | Nature Reviews Immunology | 2019 | 137 |
| 29 | Federated deep learning for detecting COVID-19 lung abnormalities in CT: a privacy-preserving multinational validation study | Npj Digital Medicine | 2021 | 134 |
| 30 | Gut microbiota–specific IgA + B cells traffic to the CNS in active multiple sclerosis | Science Immunology | 2020 | 132 |
| 31 | Patch repair of deep wounds by mobilized fascia | Nature | 2019 | 129 |
| 32 | Activity and Adverse Events of Actinium-225-PSMA-617 in Advanced Metastatic Castration-resistant Prostate Cancer After Failure of Lutetium-177-PSMA | European Urology | 2021 | 128 |
| 33 | COVID-19 in cancer patients: clinical characteristics and outcome—an analysis of the LEOSS registry | Annals of Hematology | 2021 | 127 |
| 34 | Immune deficiency is a risk factor for severe COVID‐19 in people living with HIV | HIV Medicine | 2021 | 123 |
| 35 | A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain | Nature Cell Biology | 2019 | 122 |
| 36 | Neural Correlates of Verbal Working Memory: An fMRI Meta-Analysis | Frontiers in Human Neuroscience | 2019 | 121 |
| 37 | The substrate repertoire of γ-secretase/presenilin | Seminars in Cell and Developmental Biology | 2020 | 115 |
| 38 | App-based multidisciplinary back pain treatment versus combined physiotherapy plus online education: a randomized controlled trial | Npj Digital Medicine | 2019 | 114 |
| 39 | SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19 | The Cochrane Library | 2021 | 114 |
| 40 | Psychosocial and psychological interventions for relapse prevention in schizophrenia: a systematic review and network meta-analysis | Lancet Psychiatry,the | 2021 | 114 |
| 41 | Heterologous prime–boost vaccination with ChAdOx1 nCoV-19 and BNT162b2 | Lancet Infectious Diseases, The | 2021 | 111 |
| 42 | Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs | Journal of Allergy and Clinical Immunology: in Practice | 2020 | 107 |
| 43 | Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients | Cell Metabolism | 2018 | 105 |
| 44 | International prognostic scoring system for mastocytosis (IPSM): a retrospective cohort study | Lancet Haematology,the | 2019 | 101 |
| 45 | Disorders of the enteric nervous system — a holistic view | Nature Reviews Gastroenterology and Hepatology | 2021 | 100 |
| 46 | European Task Force on Atopic Dermatitis statement on severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2) infection and atopic dermatitis | Journal of the European Academy of Dermatology and Venereology | 2020 | 99 |
| 47 | Rates of bacterial co-infections and antimicrobial use in COVID-19 patients: a retrospective cohort study in light of antibiotic stewardship | European Journal of Clinical Microbiology and Infectious Diseases | 2021 | 98 |
| 48 | Bright Chromenylium Polymethine Dyes Enable Fast, Four-Color In Vivo Imaging with Shortwave Infrared Detection | Journal of the American Chemical Society | 2021 | 98 |
| 49 | Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum | JAMA Neurology | 2022 | 97 |
| 50 | Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999–2019: an epidemiological investigation | Lancet Infectious Diseases, The | 2020 | 96 |
