| # | Title | Journal | Year | Citations |
|---|
| 1 | ESPEN guidelines on definitions and terminology of clinical nutrition | Clinical Nutrition | 2017 | 1,451 |
| 2 | Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients | Neuroscience Letters | 1994 | 884 |
| 3 | De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia | Molecular Psychiatry | 2012 | 775 |
| 4 | Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients | Neuroscience Letters | 1994 | 770 |
| 5 | Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments | Archives of Virology | 2008 | 642 |
| 6 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 629 |
| 7 | Proline-directed and Non-proline-directed Phosphorylation of PHF-tau | Journal of Biological Chemistry | 1995 | 528 |
| 8 | Estrogen Masculinizes Neural Pathways and Sex-Specific Behaviors | Cell | 2009 | 354 |
| 9 | Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 335 |
| 10 | Classification of HHV-6A and HHV-6B as distinct viruses | Archives of Virology | 2014 | 292 |
| 11 | Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS) | Atherosclerosis | 2008 | 289 |
| 12 | Oral hypofunction in the older population: Position paper of the Japanese Society of Gerodontology in 2016 | Gerodontology | 2018 | 264 |
| 13 | Brain aromatase is neuroprotective | Journal of Neurobiology | 2001 | 252 |
| 14 | Role of anti-oncomirs miR-143 and -145 in human colorectal tumors | Cancer Gene Therapy | 2010 | 251 |
| 15 | Sarcopenia and dysphagia: Position paper by four professional organizations | Geriatrics and Gerontology International | 2019 | 249 |
| 16 | Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk | New England Journal of Medicine | 2021 | 247 |
| 17 | Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro. | Journal of Immunology | 1993 | 232 |
| 18 | Isoquinoline neurotoxins in the brain and Parkinson's disease | Neuroscience Research | 1997 | 231 |
| 19 | Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro | Journal of Immunology | 1993 | 231 |
| 20 | Immunoreactivity of VR1 on Epidermal Keratinocyte of Human Skin | Biochemical and Biophysical Research Communications | 2001 | 222 |
| 21 | Laparoscopic total gastrectomy with distal pancreatosplenectomy and D2 lymphadenectomy for advanced gastric cancer | Gastric Cancer | 1999 | 220 |
| 22 | Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy | Journal of Allergy and Clinical Immunology | 2008 | 220 |
| 23 | p53 protein, interferon-γ, and NF-κB levels are elevated in the parkinsonian brain | Neuroscience Letters | 2007 | 217 |
| 24 | IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells | Journal of Immunology | 2010 | 211 |
| 25 | Ablation of Cerebellar Golgi Cells Disrupts Synaptic Integration Involving GABA Inhibition and NMDA Receptor Activation in Motor Coordination | Cell | 1998 | 210 |
| 26 | Targeted Disruption of the Tyrosine Hydroxylase Locus Results in Severe Catecholamine Depletion and Perinatal Lethality in Mice | Journal of Biological Chemistry | 1995 | 193 |
| 27 | Triple Transduction with Adeno-Associated Virus Vectors Expressing Tyrosine Hydroxylase, Aromatic-L-Amino-Acid Decarboxylase, and GTP Cyclohydrolase I for Gene Therapy of Parkinson's Disease | Human Gene Therapy | 2000 | 191 |
| 28 | Treatment of ulcerative colitis by feeding with germinated barley foodstuff: first report of a multicenter open control trial | Journal of Gastroenterology | 2002 | 178 |
| 29 | Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT) | Molecular Psychiatry | 2014 | 178 |
| 30 | Cephalometric abnormalities in non-obese and obese patients with obstructive sleep apnoea | European Respiratory Journal | 1999 | 177 |
| 31 | Global Trend in Overweight and Obesity and Its Association With Cardiovascular Disease Incidence | Circulation Journal | 2014 | 177 |
| 32 | Detection and Characterization of Novel Rotavirus Strains in the United States | Journal of Clinical Microbiology | 1998 | 176 |
| 33 | Induction therapy by frequent administration of doxorubicin with four other drugs, followed by intensive consolidation and maintenance therapy for adult acute lymphoblastic leukemia: the JALSG-ALL93 study | Leukemia | 2002 | 171 |
| 34 | Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb | Neuroscience Research | 1995 | 169 |
| 35 | Automated Classification of Lung Cancer Types from Cytological Images Using Deep Convolutional Neural Networks | BioMed Research International | 2017 | 160 |
| 36 | A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RARα transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study | Blood | 2007 | 158 |
| 37 | Expression of cytokine receptors in cultured neuronal and glial cells | Neuroscience Letters | 1993 | 156 |
| 38 | Genome-Wide Association Study of Schizophrenia in a Japanese Population | Biological Psychiatry | 2011 | 152 |
| 39 | Synaptic Integration Mediated by Striatal Cholinergic Interneurons in Basal Ganglia Function | Science | 2000 | 151 |
| 40 | L-dopa therapy for Parkinson's disease: Past, present, and future | Parkinsonism and Related Disorders | 2009 | 151 |
| 41 | Morquio disease: Isolation, characterization and expression of full-length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase | Biochemical and Biophysical Research Communications | 1991 | 150 |
| 42 | MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer | Cancer Letters | 2015 | 147 |
| 43 | Morphological transformation of microglia in vitro | Brain Research | 1991 | 146 |
| 44 | Critical re-examination of the distribution of aromatase-immunoreactive cells in the quail forebrain using antibodies raised against human placental aromatase and against the recombinant quail, mouse or human enzyme | Journal of Chemical Neuroanatomy | 1995 | 143 |
| 45 | Association Between Common Genetic Variants in Pre‐microRNAs and Gastric Cancer Risk in Japanese Population | Helicobacter | 2010 | 142 |
| 46 | Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system | Development (Cambridge) | 2002 | 141 |
| 47 | Structural characterization of the human estrogen synthetase (aromatase) gene | Biochemical and Biophysical Research Communications | 1990 | 139 |
| 48 | Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis | Gastroenterology | 2018 | 139 |
| 49 | Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses | Frontiers in Psychiatry | 2017 | 139 |
| 50 | Chewing and Food Consistency: Effects on Bolus Transport and Swallow Initiation | Dysphagia | 2007 | 136 |
