# | Title | Journal | Year | Citations |
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1 | Wnt signalling in stem cells and cancer | Nature | 2005 | 3,334 |
2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
3 | The Warburg Effect: How Does it Benefit Cancer Cells? | Trends in Biochemical Sciences | 2016 | 3,019 |
4 | Wnt proteins are lipid-modified and can act as stem cell growth factors | Nature | 2003 | 2,006 |
5 | A role for Wnt signalling in self-renewal of haematopoietic stem cells | Nature | 2003 | 1,981 |
6 | Cell cycle checkpoint signaling through the ATM and ATR kinases | Genes and Development | 2001 | 1,716 |
7 | Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets | Journal of Immunology | 2011 | 1,645 |
8 | Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells | Cancer Cell | 2009 | 1,196 |
9 | Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE | Science | 2010 | 1,124 |
10 | Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin | Molecular and Cellular Biology | 2002 | 1,106 |
11 | Metabolic Regulation of T Lymphocytes | Annual Review of Immunology | 2013 | 1,050 |
12 | The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1 | Endocrinology | 1999 | 939 |
13 | Signaling cross-talk between TGF-β/BMP and other pathways | Cell Research | 2009 | 870 |
14 | Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia | Nature | 2009 | 801 |
15 | Comprehensive analysis of the chromatin landscape in Drosophila melanogaster | Nature | 2011 | 781 |
16 | Unlocking the secrets of the genome | Nature | 2009 | 744 |
17 | Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance | Nature Immunology | 2005 | 712 |
18 | Subtypes of medulloblastoma have distinct developmental origins | Nature | 2010 | 710 |
19 | A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells | Nature Cell Biology | 2004 | 687 |
20 | Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways | Journal of Immunology | 2008 | 675 |
21 | Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis | Journal of Clinical Oncology | 2008 | 665 |
22 | Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion | Cell | 2000 | 631 |
23 | Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells | Cancer Cell | 2008 | 606 |
24 | Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In Vivo | Cancer Cell | 2007 | 569 |
25 | Connections and Regulation of the Human Estrogen Receptor | Science | 2002 | 518 |
26 | Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway | Cancer Cell | 2004 | 509 |
27 | Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth | Molecular Cell | 2015 | 509 |
28 | Notch Promotes Radioresistance of Glioma Stem Cells | Stem Cells | 2010 | 505 |
29 | Fetal nicotine or cocaine exposure: which one is worse? | Journal of Pharmacology and Experimental Therapeutics | 1998 | 501 |
30 | Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells | Journal of Biological Chemistry | 2003 | 490 |
31 | Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis | Journal of Cell Biology | 2000 | 489 |
32 | Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking | Molecular Biology of the Cell | 2007 | 483 |
33 | A cis-regulatory map of the Drosophila genome | Nature | 2011 | 477 |
34 | Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates | Toxicology and Applied Pharmacology | 2004 | 474 |
35 | Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome With Liver and Adipose Inflammation: Comparison to High‐Fat Diet | Obesity | 2011 | 467 |
36 | TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma | Cancer Cell | 2012 | 466 |
37 | Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction | Molecular and Cellular Biology | 1999 | 458 |
38 | Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth | Cancer Cell | 2010 | 454 |
39 | Regulation of Cell Cycle Progression by Calcium/Calmodulin-Dependent Pathways | Endocrine Reviews | 2003 | 428 |
40 | Copper is required for oncogenic BRAF signalling and tumorigenesis | Nature | 2014 | 425 |
41 | BMP10 is essential for maintaining cardiac growth during murine cardiogenesis | Development (Cambridge) | 2004 | 421 |
42 | Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress | Genes and Development | 2000 | 417 |
43 | Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 417 |
44 | Caspases and Kinases in a Death Grip | Cell | 2009 | 394 |
45 | Protein prenylation: unique fats make their mark on biology | Nature Reviews Molecular Cell Biology | 2016 | 393 |
46 | TGF-β Family Signaling in the Control of Cell Proliferation and Survival | Cold Spring Harbor Perspectives in Biology | 2017 | 390 |
47 | c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF | Genes and Development | 1999 | 378 |
48 | Brain anomalies in children exposed prenatally to a common organophosphate pesticide | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 378 |
49 | The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae | EMBO Journal | 1998 | 370 |
50 | Comparative analysis of metazoan chromatin organization | Nature | 2014 | 363 |