| Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints | Nature Communications | 2016 | 846 |
| In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy | Science | 2016 | 774 |
| The Warwick Agreement on femoroacetabular impingement syndrome (FAI syndrome): an international consensus statement | British Journal of Sports Medicine | 2016 | 490 |
| Mechanism of hard-nanomaterial clearance by the liver | Nature Materials | 2016 | 463 |
| Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy | New England Journal of Medicine | 2016 | 444 |
| Genome-editing Technologies for Gene and Cell Therapy | Molecular Therapy | 2016 | 413 |
| Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice | Acta Anaesthesiologica Scandinavica | 2016 | 347 |
| STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment | Cancer Research | 2016 | 297 |
| Editing the epigenome: technologies for programmable transcription and epigenetic modulation | Nature Methods | 2016 | 272 |
| Epidemiology of Fracture Nonunion in 18 Human Bones | JAMA Surgery | 2016 | 231 |
| Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer | Journal of Allergy and Clinical Immunology | 2016 | 168 |
| From the RNA world to the clinic | Science | 2016 | 168 |
| A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer | Science Translational Medicine | 2016 | 163 |
| American Society for Metabolic and Bariatric Surgery estimation of bariatric surgery procedures in 2015 and surgeon workforce in the United States | Surgery for Obesity and Related Diseases | 2016 | 140 |
| Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells | Cell Stem Cell | 2016 | 139 |
| Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ | Annals of Surgical Oncology | 2016 | 123 |
| PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS | Journal of Medical Genetics | 2016 | 121 |
| Minimally Invasive Versus Open Esophagectomy for Esophageal Cancer: A Population-Based Analysis | Annals of Thoracic Surgery | 2016 | 107 |
| Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection | PLoS Pathogens | 2016 | 106 |
| Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report | Journal of Nuclear Medicine | 2016 | 101 |
| Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C | PLoS Pathogens | 2016 | 101 |
| Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support | Journal of the American College of Cardiology | 2016 | 98 |
| Gait Speed and Operative Mortality in Older Adults Following Cardiac Surgery | JAMA Cardiology | 2016 | 98 |
| Use and Outcomes of Minimally Invasive Lobectomy for Stage I Non-Small Cell Lung Cancer in the National Cancer Data Base | Annals of Thoracic Surgery | 2016 | 95 |
| Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma in Situ | Practical Radiation Oncology | 2016 | 92 |
