| # | Title | Journal | Year | Citations |
|---|
| 1 | Glioma stem cells promote radioresistance by preferential activation of the DNA damage response | Nature | 2006 | 5,600 |
| 2 | Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes | Science | 1999 | 2,072 |
| 3 | Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix | Cell Stem Cell | 2009 | 1,669 |
| 4 | Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013 | JAMA - Journal of the American Medical Association | 2017 | 1,475 |
| 5 | Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor | Cancer Research | 2006 | 1,239 |
| 6 | Consensus Guidelines for the Management of Postoperative Nausea and Vomiting | Anesthesia and Analgesia | 2014 | 1,200 |
| 7 | Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells | Cancer Cell | 2009 | 1,196 |
| 8 | BRCA1 mutations in primary breast and ovarian carcinomas | Science | 1994 | 1,167 |
| 9 | Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints | Nature Communications | 2016 | 1,163 |
| 10 | Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation | Nature Medicine | 1998 | 1,079 |
| 11 | Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies | Journal of Virology | 2005 | 1,025 |
| 12 | Isolation of a human prostate carcinoma cell line (DU 145) | International Journal of Cancer | 1978 | 1,017 |
| 13 | Phase II Trial of Bevacizumab and Irinotecan in Recurrent Malignant Glioma | Clinical Cancer Research | 2007 | 1,005 |
| 14 | Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck | International Journal of Radiation Oncology Biology Physics | 1997 | 990 |
| 15 | Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1 | Science | 1991 | 970 |
| 16 | Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras | Nature Biotechnology | 2006 | 964 |
| 17 | Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection. | Proceedings of the National Academy of Sciences of the United States of America | 1994 | 947 |
| 18 | Seven-transmembrane-spanning receptors and heart function | Nature | 2002 | 862 |
| 19 | Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. | Journal of Experimental Medicine | 1996 | 854 |
| 20 | Clinical Practice Guideline | Otolaryngology - Head and Neck Surgery | 2012 | 787 |
| 21 | The Impact of Surgical-Site Infections Following Orthopedic Surgery at a Community Hospital and a University Hospital Adverse Quality of Life, Excess Length of Stay, and Extra Cost | Infection Control and Hospital Epidemiology | 2002 | 762 |
| 22 | Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds | Biomaterials | 2004 | 728 |
| 23 | Teaching old receptors new tricks: biasing seven-transmembrane receptors | Nature Reviews Drug Discovery | 2010 | 724 |
| 24 | Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor | Science | 1994 | 721 |
| 25 | Thoracoscopic lobectomy is associated with lower morbidity than open lobectomy: A propensity-matched analysis from the STS database | Journal of Thoracic and Cardiovascular Surgery | 2010 | 721 |
| 26 | Neurogenic differentiation of murine and human adipose-derived stromal cells | Biochemical and Biophysical Research Communications | 2002 | 717 |
| 27 | Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor | Science | 1995 | 704 |
| 28 | Noninvasive Staging of Non-small Cell Lung Cancer* | Chest | 2003 | 676 |
| 29 | A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage | Nature Materials | 2007 | 672 |
| 30 | Estimates and Patterns of Direct Health Care Expenditures Among Individuals With Back Pain in the United States | Spine | 2004 | 666 |
| 31 | Randomized Comparison of Percutaneous Repair and Surgery for Mitral Regurgitation | Journal of the American College of Cardiology | 2015 | 658 |
| 32 | The Genetic Landscape of the Childhood Cancer Medulloblastoma | Science | 2011 | 652 |
| 33 | Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets | Cancer Cell | 2019 | 636 |
| 34 | Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes | Nature | 2002 | 628 |
| 35 | Chondrogenic Potential of Adipose Tissue-Derived Stromal Cells in Vitro and in Vivo | Biochemical and Biophysical Research Communications | 2002 | 626 |
| 36 | Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging | Nanotechnology | 2012 | 619 |
| 37 | Cochlear implants: A remarkable past and a brilliant future | Hearing Research | 2008 | 607 |
| 38 | Integrin Alpha 6 Regulates Glioblastoma Stem Cells | Cell Stem Cell | 2010 | 597 |
| 39 | Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies | Journal of Virology | 2010 | 589 |
| 40 | Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers | Molecular Cancer Research | 2011 | 586 |
| 41 | Depression as a risk factor for mortality after coronary artery bypass surgery | Lancet, The | 2003 | 577 |
| 42 | Genomic signatures to guide the use of chemotherapeutics | Nature Medicine | 2006 | 557 |
| 43 | Hepatic Insufficiency and Mortality in 1,059 Noncirrhotic Patients Undergoing Major Hepatectomy | Journal of the American College of Surgeons | 2007 | 550 |
| 44 | Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia | Journal of Virology | 2008 | 548 |
| 45 | Functional Tissue Engineering: The Role of Biomechanics | Journal of Biomechanical Engineering | 2000 | 538 |
| 46 | Increased Regulatory T-Cell Fraction Amidst a Diminished CD4 Compartment Explains Cellular Immune Defects in Patients with Malignant Glioma | Cancer Research | 2006 | 533 |
| 47 | Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas | Oncotarget | 2012 | 532 |
| 48 | Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury | Nature Medicine | 1995 | 531 |
| 49 | A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 522 |
| 50 | Surgical Complications Associated With Sentinel Lymph Node Biopsy: Results From a Prospective International Cooperative Group Trial | Annals of Surgical Oncology | 2006 | 506 |
