| # | Title | Journal | Year | Citations |
|---|
| 1 | Environmental epigenomics and disease susceptibility | Nature Reviews Genetics | 2007 | 2,180 |
| 2 | Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation | Molecular and Cellular Biology | 2003 | 1,874 |
| 3 | Hyperfractionated Irradiation with or without Concurrent Chemotherapy for Locally Advanced Head and Neck Cancer | New England Journal of Medicine | 1998 | 1,059 |
| 4 | Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck | International Journal of Radiation Oncology Biology Physics | 1997 | 990 |
| 5 | Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors | Cancer Cell | 2004 | 963 |
| 6 | A dual-emissive-materials design concept enables tumour hypoxia imaging | Nature Materials | 2009 | 941 |
| 7 | Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response | Nature Reviews Cancer | 2008 | 907 |
| 8 | Maternal Genistein Alters Coat Color and Protects A vy Mouse Offspring from Obesity by Modifying the Fetal Epigenome | Environmental Health Perspectives | 2006 | 877 |
| 9 | Diagnosis-Specific Prognostic Factors, Indexes, and Treatment Outcomes for Patients With Newly Diagnosed Brain Metastases: A Multi-Institutional Analysis of 4,259 Patients | International Journal of Radiation Oncology Biology Physics | 2010 | 873 |
| 10 | Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia | International Journal of Hyperthermia | 2003 | 789 |
| 11 | Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer | Journal of Clinical Oncology | 2000 | 756 |
| 12 | Polymer gel dosimetry | Physics in Medicine and Biology | 2010 | 755 |
| 13 | Effects of radiation on normal tissue: consequences and mechanisms | Lancet Oncology, The | 2003 | 744 |
| 14 | Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases | Nutrition | 2004 | 714 |
| 15 | Radiation pneumonitis as a function of mean lung dose: an analysis of pooled data of 540 patients | International Journal of Radiation Oncology Biology Physics | 1998 | 664 |
| 16 | Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences | Nature | 2007 | 661 |
| 17 | Radiation Dose–Volume Effects in the Brain | International Journal of Radiation Oncology Biology Physics | 2010 | 620 |
| 18 | Radiation-Associated Liver Injury | International Journal of Radiation Oncology Biology Physics | 2010 | 592 |
| 19 | Biomarkers of response and resistance to antiangiogenic therapy | Nature Reviews Clinical Oncology | 2009 | 541 |
| 20 | Oxidants, antioxidants and the ischemic brain | Journal of Experimental Biology | 2004 | 531 |
| 21 | Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome | Radiotherapy and Oncology | 1999 | 518 |
| 22 | Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth | Molecular Cell | 2015 | 509 |
| 23 | The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors | Advanced Drug Delivery Reviews | 2001 | 506 |
| 24 | Transport of drugs from blood vessels to tumour tissue | Nature Reviews Cancer | 2017 | 499 |
| 25 | Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study | Journal of Clinical Oncology | 2009 | 487 |
| 26 | Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer | International Journal of Radiation Oncology Biology Physics | 2001 | 469 |
| 27 | Radiation Dose–Volume Effects in the Stomach and Small Bowel | International Journal of Radiation Oncology Biology Physics | 2010 | 457 |
| 28 | Epigenetic gene regulation: Linking early developmental environment to adult disease | Reproductive Toxicology | 2007 | 456 |
| 29 | Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer | International Journal of Radiation Oncology Biology Physics | 2001 | 451 |
| 30 | Maternal methyl supplements increase offspring DNA methylation atAxin fused | Genesis | 2006 | 450 |
| 31 | Radiation Dose–Volume Effects in the Spinal Cord | International Journal of Radiation Oncology Biology Physics | 2010 | 445 |
| 32 | The Linear-Quadratic Model Is Inappropriate to Model High Dose per Fraction Effects in Radiosurgery | Seminars in Radiation Oncology | 2008 | 442 |
| 33 | Radiation Dose–Volume Effects of Optic Nerves and Chiasm | International Journal of Radiation Oncology Biology Physics | 2010 | 438 |
| 34 | Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline | Practical Radiation Oncology | 2018 | 431 |
| 35 | Dietary methionine influences therapy in mouse cancer models and alters human metabolism | Nature | 2019 | 422 |
| 36 | The incidence and functional consequences of RT-associated cardiac perfusion defects | International Journal of Radiation Oncology Biology Physics | 2005 | 421 |
| 37 | Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis | PLoS ONE | 2012 | 412 |
| 38 | Surrogate Markers for Antiangiogenic Therapy and Dose-Limiting Toxicities for Bevacizumab With Radiation and Chemotherapy: Continued Experience of a Phase I Trial in Rectal Cancer Patients | Journal of Clinical Oncology | 2005 | 410 |
| 39 | Regulation of HIF-1α Stability through S-Nitrosylation | Molecular Cell | 2007 | 399 |
| 40 | Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors | Cancer Research | 2012 | 398 |
| 41 | Drug targeting using thermally responsive polymers and local hyperthermia | Journal of Controlled Release | 2001 | 392 |
| 42 | Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity | Cancer Cell | 2005 | 381 |
| 43 | Fractionation for Whole Breast Irradiation: An American Society for Radiation Oncology (ASTRO) Evidence-Based Guideline | International Journal of Radiation Oncology Biology Physics | 2011 | 366 |
| 44 | Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment | Cancer and Metastasis Reviews | 2007 | 364 |
| 45 | Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer | International Journal of Radiation Oncology Biology Physics | 2014 | 364 |
| 46 | Injury to the lung from cancer therapy: Clinical syndromes, measurable endpoints, and potential scoring systems | International Journal of Radiation Oncology Biology Physics | 1995 | 359 |
| 47 | The response of the urinary bladder, urethra, and ureter to radiation and chemotherapy | International Journal of Radiation Oncology Biology Physics | 1995 | 358 |
| 48 | M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity | Nature Genetics | 1995 | 352 |
| 49 | Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer | Annals of Surgical Oncology | 2014 | 348 |
| 50 | Genomic Imprinting: Implications for Human Disease | American Journal of Pathology | 1999 | 337 |
