| # | Title | Journal | Year | Citations |
|---|
| 1 | IDH1andIDH2Mutations in Gliomas | New England Journal of Medicine | 2009 | 5,285 |
| 2 | PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer | Science | 1997 | 4,506 |
| 3 | The Somatic Genomic Landscape of Glioblastoma | Cell | 2013 | 3,979 |
| 4 | Genes Expressed in Human Tumor Endothelium | Science | 2000 | 1,733 |
| 5 | TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 1,202 |
| 6 | Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells | Cancer Cell | 2009 | 1,196 |
| 7 | A copy number variation morbidity map of developmental delay | Nature Genetics | 2011 | 1,141 |
| 8 | Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2 | Nature Genetics | 1996 | 1,031 |
| 9 | The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota | Hepatology | 2016 | 1,029 |
| 10 | Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors | Cancer Cell | 2004 | 963 |
| 11 | Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis | Hepatology | 2007 | 879 |
| 12 | von Willebrand disease (VWD): evidence‐based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)1 | Haemophilia | 2008 | 815 |
| 13 | Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 | Nature | 2011 | 794 |
| 14 | Spatial Organization and Composition of the Mucosal Flora in Patients with Inflammatory Bowel Disease | Journal of Clinical Microbiology | 2005 | 755 |
| 15 | Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. | Circulation Research | 1990 | 743 |
| 16 | Immunosenescence of ageing | Journal of Pathology | 2007 | 730 |
| 17 | A Pathogenetic Role for TNFα in the Syndrome of Cachexia, Arthritis, and Autoimmunity Resulting from Tristetraprolin (TTP) Deficiency | Immunity | 1996 | 726 |
| 18 | Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth | Nature Cell Biology | 2015 | 716 |
| 19 | Quinone chemistry and toxicity | Toxicology and Applied Pharmacology | 1992 | 697 |
| 20 | The Genetic Landscape of the Childhood Cancer Medulloblastoma | Science | 2011 | 652 |
| 21 | Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy | Nature Medicine | 2012 | 647 |
| 22 | Patient age, histologic features, and length of survival in patients with glioblastoma multiforme | Cancer | 1987 | 629 |
| 23 | Identification of an amplified, highly expressed gene in a human glioma | Science | 1987 | 621 |
| 24 | Glioblastoma multiforme and anaplastic astrocytoma pathologic criteria and prognostic implications | Cancer | 1985 | 612 |
| 25 | Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In Vivo | Cancer Cell | 2007 | 569 |
| 26 | Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas | Oncotarget | 2012 | 532 |
| 27 | Angiostatin binds ATP synthase on the surface of human endothelial cells | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 474 |
| 28 | Readily Available Tissue-Engineered Vascular Grafts | Science Translational Medicine | 2011 | 468 |
| 29 | A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo | Cancer Research | 2016 | 453 |
| 30 | Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism | Journal of the National Cancer Institute | 2010 | 448 |
| 31 | Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors | Nature Medicine | 2018 | 437 |
| 32 | Heterogeneity of Genotypic and Phenotypic Characteristics of Fifteen Permanent Cell Lines Derived from Human Gliomas | Journal of Neuropathology and Experimental Neurology | 1981 | 433 |
| 33 | Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH | Nature Medicine | 1996 | 429 |
| 34 | Bone Marrow–generated Dendritic Cells Pulsed with Tumor Extracts or Tumor RNA Induce Antitumor Immunity against Central Nervous System Tumors | Journal of Experimental Medicine | 1997 | 419 |
| 35 | The Effect of Temperature and pH on the Activity of Factor VIIa: Implications for the Efficacy of High-Dose Factor VIIa in Hypothermic and Acidotic Patients | Journal of Trauma | 2003 | 415 |
| 36 | Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis | PLoS ONE | 2012 | 412 |
| 37 | Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial | Lancet, The | 2019 | 401 |
| 38 | Distribution of α2-adrenergic receptor subtype gene expression in rat brain | Molecular Brain Research | 1994 | 398 |
| 39 | Topographic anatomy and CT correlations in the untreated glioblastoma multiforme | Journal of Neurosurgery | 1988 | 397 |
| 40 | Increasing incidence of primary brain lymphoma in the US | Cancer | 1988 | 396 |
| 41 | Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties | FEBS Journal | 1990 | 386 |
| 42 | Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity | Cancer Cell | 2005 | 381 |
| 43 | Clinical and Pathologic Features of Familial Interstitial Pneumonia | American Journal of Respiratory and Critical Care Medicine | 2005 | 381 |
| 44 | Prolonged depletion of ATP and of the adenine nucleotide pool due to delayed resynthesis of adenine nucleotides following reversible myocardial ischemic injury in dogs | Journal of Molecular and Cellular Cardiology | 1981 | 380 |
| 45 | Adherent Biofilms in Bacterial Vaginosis | Obstetrics and Gynecology | 2005 | 371 |
| 46 | Proteomic and immunologic analyses of brain tumor exosomes | FASEB Journal | 2009 | 369 |
| 47 | Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes | Cancer Research | 1989 | 367 |
| 48 | Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. | Circulation Research | 1990 | 363 |
| 49 | Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas | Cancer Research | 1995 | 363 |
| 50 | Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 357 |
