| # | Title | Journal | Year | Citations |
|---|
| 1 | Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families | Science | 1993 | 8,329 |
| 2 | Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee | Journal of Bone and Mineral Research | 1987 | 4,558 |
| 3 | Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management | Clinical Microbiology Reviews | 2015 | 3,304 |
| 4 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance | Cell Metabolism | 2009 | 2,597 |
| 5 | Endoscopic sphincterotomy complications and their management: an attempt at consensus | Gastrointestinal Endoscopy | 1991 | 2,535 |
| 6 | Seven-transmembrane receptors | Nature Reviews Molecular Cell Biology | 2002 | 2,357 |
| 7 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 8 | Protein S-nitrosylation: purview and parameters | Nature Reviews Molecular Cell Biology | 2005 | 1,910 |
| 9 | Changes in thymic function with age and during the treatment of HIV infection | Nature | 1998 | 1,778 |
| 10 | Programmed cell death induced by ceramide | Science | 1993 | 1,735 |
| 11 | Redox signaling: Nitrosylation and related target interactions of nitric oxide | Cell | 1994 | 1,726 |
| 12 | Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression | Free Radical Biology and Medicine | 2002 | 1,720 |
| 13 | Liver biopsy | Hepatology | 2009 | 1,696 |
| 14 | Utilization of the PICO framework to improve searching PubMed for clinical questions | BMC Medical Informatics and Decision Making | 2007 | 1,667 |
| 15 | Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report | Journal of Allergy and Clinical Immunology | 2010 | 1,614 |
| 16 | S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control | Nature | 1996 | 1,584 |
| 17 | Functions of Ceramide in Coordinating Cellular Responses to Stress | Science | 1996 | 1,576 |
| 18 | Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells | Nature Medicine | 2005 | 1,512 |
| 19 | A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation | Cell | 1994 | 1,510 |
| 20 | Regression modelling strategies for improved prognostic prediction | Statistics in Medicine | 1984 | 1,486 |
| 21 | The Impact of Surgical-Site Infections in the 1990s: Attributable Mortality, Excess Length of Hospitalization, And Extra Costs | Infection Control and Hospital Epidemiology | 1999 | 1,448 |
| 22 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 23 | A brief self-administered questionnaire to determine functional capacity (The Duke Activity Status Index) | American Journal of Cardiology | 1989 | 1,422 |
| 24 | β-Arrestin-Dependent Formation of β2Adrenergic Receptor-Src Protein Kinase Complexes | Science | 1999 | 1,375 |
| 25 | Type 2 alveolar cells are stem cells in adult lung | Journal of Clinical Investigation | 2013 | 1,352 |
| 26 | The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA | Nature | 1989 | 1,350 |
| 27 | β-Arrestins and Cell Signaling | Annual Review of Physiology | 2007 | 1,277 |
| 28 | Functions of sphingolipids and sphingolipid breakdown products in cellular regulation | Science | 1989 | 1,260 |
| 29 | Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC) | Blood | 2007 | 1,243 |
| 30 | Effects of the Amount and Intensity of Exercise on Plasma Lipoproteins | New England Journal of Medicine | 2002 | 1,198 |
| 31 | Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A | Nature | 1997 | 1,176 |
| 32 | Chiari I Malformation Redefined: Clinical and Radiographic Findings for 364 Symptomatic Patients | Neurosurgery | 1999 | 1,149 |
| 33 | Evidence supporting paracrine hypothesis for Akt‐modified mesenchymal stem cell‐mediated cardiac protection and functional improvement | FASEB Journal | 2006 | 1,082 |
| 34 | Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation | Nature Medicine | 1998 | 1,079 |
| 35 | A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets | Nature Genetics | 1995 | 1,067 |
| 36 | Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2 | Nature Genetics | 1996 | 1,031 |
| 37 | Blood Flow Regulation by S-Nitrosohemoglobin in the Physiological Oxygen Gradient | Science | 1997 | 1,030 |
| 38 | The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota | Hepatology | 2016 | 1,029 |
| 39 | The sphingomyelin cycle and the second messenger function of ceramide | Journal of Biological Chemistry | 1994 | 968 |
| 40 | A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis | Science | 2005 | 967 |
| 41 | Surface protein characterization of human adipose tissue-derived stromal cells | Journal of Cellular Physiology | 2001 | 965 |
| 42 | Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes | Nature | 2010 | 965 |
| 43 | Physiology of Nitric Oxide in Skeletal Muscle | Physiological Reviews | 2001 | 897 |
| 44 | A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer | Journal of Translational Medicine | 2005 | 870 |
| 45 | Adverse Clinical and Economic Outcomes Attributable to Methicillin Resistance among Patients withStaphylococcus aureusSurgical Site Infection | Clinical Infectious Diseases | 2003 | 860 |
| 46 | ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy | Nature | 2017 | 852 |
| 47 | Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 849 |
| 48 | Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: An in vitro model of osteoblast development | Journal of Bone and Mineral Research | 1992 | 842 |
| 49 | NAFLD, NASH and liver cancer | Nature Reviews Gastroenterology and Hepatology | 2013 | 842 |
| 50 | Establishing the Diagnosis of Lung Cancer | Chest | 2013 | 825 |
