| # | Title | Journal | Year | Citations |
|---|
| 1 | Molecular structure of a left-handed double helical DNA fragment at atomic resolution | Nature | 1979 | 2,099 |
| 2 | Left-handed double helical DNA: variations in the backbone conformation | Science | 1981 | 596 |
| 3 | Preparation and NMR characterization of highly substitutedN-trimethyl chitosan chloride | Carbohydrate Polymers | 1998 | 387 |
| 4 | Application of self-consistent-fieldab initiocalculations to organic molecules | Molecular Physics | 1976 | 278 |
| 5 | Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound | Nature | 1978 | 211 |
| 6 | Conformational analysis of nucleic acids. Determination of backbone geometry of single‐helical RNA and DNA in aqueous solution | Recueil Des Travaux Chimiques Des Pays-Bas | 1982 | 194 |
| 7 | Photochemistry of Vitamin D and its Isomers and of Simple Trienes | Advances in Photochemistry | 2007 | 170 |
| 8 | Conformationally restricted amino acids and dipeptides, (non)peptidomimetics and secondary structure mimetics | Recueil Des Travaux Chimiques Des Pays-Bas | 1994 | 167 |
| 9 | Pyrromethene‐BF2 complexes (4,4′‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacenes). Synthesis and luminescence properties | Recueil Des Travaux Chimiques Des Pays-Bas | 1977 | 126 |
| 10 | Carboxyfluorescein fluorochromasia assays. I. Non-radio actively labeled cell mediated lympholysis | Journal of Immunological Methods | 1980 | 113 |
| 11 | Thermodynamic and structural aspects of the skin barrier | Journal of Controlled Release | 1991 | 112 |
| 12 | Evidence that rat liver microsomal glutathione transferase is responsible for glutathione-dependent protection against lipid peroxidation | Biochemical Pharmacology | 1993 | 110 |
| 13 | The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and γ-glutamyl domains | Biochemical Journal | 1990 | 103 |
| 14 | Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation | PLoS ONE | 2009 | 96 |
| 15 | Effect of N-alkyl-azocycloheptan-2-ones including azone on the thermal behaviour of human stratum corneum | International Journal of Pharmaceutics | 1989 | 94 |
| 16 | Application of self-consistent-field ab initio calculations to organic molecules | Molecular Physics | 1976 | 89 |
| 17 | Application of self-consistent-field ab initio calculations to organic molecules | Molecular Physics | 1976 | 89 |
| 18 | Lysis gene of bacteriophage MS2 is activated by translation termination at the overlapping coat gene | Journal of Molecular Biology | 1987 | 85 |
| 19 | Conformational equilibrium and photochemistry of hexa-1,3,5-trienes | Tetrahedron | 1973 | 84 |
| 20 | Convenient fluorometric assay for matrix metalloproteinase activity and its application in biological media | FEBS Letters | 1996 | 84 |
| 21 | Synthesis of complementary DNA fragments via phosphotriester intermediates | Recueil Des Travaux Chimiques Des Pays-Bas | 1979 | 83 |
| 22 | Virus-induced synthesis of messenger RNAs for precursors of pathogenesis-related proteins in tobacco | EMBO Journal | 1985 | 77 |
| 23 | Kinetics, ultrastructural aspects and molecular modelling of transdermal peptide flux enhancement by N-alkylazacycloheptanones | International Journal of Pharmaceutics | 1991 | 77 |
| 24 | A novel water‐soluble fluorescent probe: Synthesis, luminescence and biological properties of the sodium salt of the 4‐sulfonato‐3,3′,5,5′‐tetramethyl‐2,2′‐pyrromethen‐1,1′‐BF2 complex | Recueil Des Travaux Chimiques Des Pays-Bas | 1985 | 75 |
| 25 | Application of self-consistent-field ab initio calculations to organic molecules | Molecular Physics | 1977 | 71 |
| 26 | High-resolution solid-state 13C-NMR study of carbons C-5 and C-12 of the chromophore of bovine rhodopsin. Evidence for a 6-S-cis conformation with negative-charge perturbation near C-12 | FEBS Journal | 1987 | 71 |
| 27 | Application of self-consistent-field ab initio calculations to organic molecules | Molecular Physics | 1977 | 70 |
| 28 | 10,20-Methanorhodopsins: (7E, 9E, 13E)-10, 20-methanorhodopsin and (7E, 9Z, 13Z)-10, 20-methanorhodopsin. 11-cis-Locked rhodopsin analog pigments with unusual thermal and photo-stability | FEBS Journal | 1990 | 65 |
| 29 | The application of levulinic acid as protective group to the synthesis of tetradecaribonucleotide U‐A‐U‐A‐U‐A‐U‐A‐U‐A‐U‐A‐U‐A via the modified phosphotriester method | Recueil Des Travaux Chimiques Des Pays-Bas | 1978 | 62 |
| 30 | Effects of wavelength and conformation on the photochemistry of vitamin D and related conjugated trienes | Tetrahedron Letters | 1981 | 59 |
| 31 | Repetitive batch as an efficient method for preparative scale enzymic synthesis of 5-azido-neuraminic acid and 15N-l-glutamic acid | Tetrahedron: Asymmetry | 1993 | 59 |
| 32 | A novel and flexible synthesis of pyranose spiroacetal derivatives | Tetrahedron Letters | 1998 | 58 |
| 33 | Construction of viable and lethal mutations in the origin of bacteriophage φX174 using synthetic oligodeoxyribonucleotides | Journal of Molecular Biology | 1981 | 56 |
| 34 | All E‐10,20‐methanoretinoylopsin, light‐stable rhodopsin. Synthesis and spectroscopy of all E‐10,20‐methano‐ and all‐E‐retinoyl fluoride and their reaction with bovine opsin | Recueil Des Travaux Chimiques Des Pays-Bas | 1989 | 55 |
| 35 | Interaction of rat glutathione S-transferases 7-7 and 8-8 with γ-glutamyl- or glycyl-modified glutathione analogues | Biochemical Journal | 1989 | 52 |
| 36 | Application of self-consistent-field ab initio calculations to organic molecules | Molecular Physics | 1977 | 51 |
| 37 | Structural Features of the DNA Hairpin d(ATCCTA-GTTA-TAGGAT): Formation of a G-A Base Pair in the Loop | Nucleic Acids Research | 1997 | 51 |
| 38 | Synthetic applications of 2-chloro-1,3-dithiane preparation of ketene dithioacetals | Tetrahedron Letters | 1977 | 50 |
| 39 | Peptide substrates for chymosin (rennin): Conformational studies of κ-casein and some κ-casein-related oligopeptides by circular dichroism and secondary structure prediction | Archives of Biochemistry and Biophysics | 1983 | 50 |
| 40 | PHOTOSENSITIZING PROPERTIES OF BACTERIOCHLOROPHYLLIN a and BACTERIOCHLORIN a, TWO DERIVATIVES OF BACTERIOCHLOROPHYLL a | Photochemistry and Photobiology | 1987 | 50 |
| 41 | Pathways and intermediates of nucleophilic aromatic photosubstitution reactions | Reviews of Chemical Intermediates | 1979 | 46 |
| 42 | Recognition sequence of bacteriophage ΦX174 gene A protein — an initiator of DNA replication | Nature | 1980 | 44 |
| 43 | Substrate specificity of rat liver glutathione S-transferase isoenzymes for a series of glutathione analogues, modified at the gamma-glutamyl moiety | Biochemical Journal | 1988 | 44 |
| 44 | Peptide substrates for chymosin (Rennin). Kinetic studies with peptides of different chain lenght including parts of the sequence 101–112 of bovine κ-casein | Biochimica Et Biophysica Acta - Biomembranes | 1976 | 41 |
| 45 | On the chemistry of RNA degradation by Fe·bleomycin | Bioorganic and Medicinal Chemistry | 1997 | 39 |
| 46 | Protection of hydroxyl- and thiol groups as 2′-0-tetrahydrofuranyl-(THF)-ethers. | Tetrahedron Letters | 1976 | 36 |
| 47 | Aldehyde enolates II direct lkylation of aldehyde anions | Tetrahedron Letters | 1978 | 36 |
| 48 | Synthetic applications of 2‐chlorotetrahydrofuran: Protection of alcohols as tetrahydro‐2‐furanyl (THF) ethers | Recueil Des Travaux Chimiques Des Pays-Bas | 1979 | 36 |
| 49 | A Horner-Wittig solution to the synthesis of ketene, O,O-acetals. | Tetrahedron Letters | 1983 | 35 |
| 50 | -methyl--anilinomethyl diphenylphosphine oxide: a versatile reagent for the synthesis of enamines | Tetrahedron Letters | 1980 | 34 |
