| # | Title | Journal | Year | Citations |
|---|
| 1 | The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux | Nature Medicine | 2001 | 798 |
| 2 | Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. | Journal of Biological Chemistry | 1993 | 477 |
| 3 | Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion | Cancer Cell | 2020 | 389 |
| 4 | Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial | Lancet Oncology, The | 2019 | 366 |
| 5 | Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI | Journal of Biological Chemistry | 1993 | 366 |
| 6 | Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study | Lancet Oncology, The | 2019 | 362 |
| 7 | A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer | Cell | 2020 | 349 |
| 8 | Activity and safety of brigatinib in ALK-rearranged non-small-cell lung cancer and other malignancies: a single-arm, open-label, phase 1/2 trial | Lancet Oncology, The | 2016 | 298 |
| 9 | A Phase 2 Multi-institutional Study of Nivolumab for Patients With Advanced Refractory Biliary Tract Cancer | JAMA Oncology | 2020 | 293 |
| 10 | Functional versus chronological age: geriatric assessments to guide decision making in older patients with cancer | Lancet Oncology, The | 2018 | 256 |
| 11 | Older adult participation in cancer clinical trials: A systematic review of barriers and interventions | Ca-A Cancer Journal for Clinicians | 2021 | 230 |
| 12 | Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer | Journal of the National Cancer Institute | 2014 | 218 |
| 13 | The Genetic/Non-genetic Duality of Drug ‘Resistance’ in Cancer | Trends in Cancer | 2018 | 201 |
| 14 | Association of Peritumoral Radiomics With Tumor Biology and Pathologic Response to Preoperative Targeted Therapy for HER2 (ERBB2)–Positive Breast Cancer | JAMA Network Open | 2019 | 196 |
| 15 | Interdisciplinary Palliative Care for Patients With Lung Cancer | Journal of Pain and Symptom Management | 2015 | 155 |
| 16 | Efficacy and Safety of Nivolumab Plus Ipilimumab versus Sunitinib in First-line Treatment of Patients with Advanced Sarcomatoid Renal Cell Carcinoma | Clinical Cancer Research | 2021 | 154 |
| 17 | TheGpx1Gene Encodes Mitochondrial Glutathione Peroxidase in the Mouse Liver | Archives of Biochemistry and Biophysics | 1997 | 153 |
| 18 | Phase I Trial of Intratumoral Injection ofCCL21Gene–Modified Dendritic Cells in Lung Cancer Elicits Tumor-Specific Immune Responses and CD8+ T-cell Infiltration | Clinical Cancer Research | 2017 | 149 |
| 19 | Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index | JAMA Oncology | 2019 | 145 |
| 20 | Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline CDH1 sequence variants | Human Mutation | 2018 | 138 |
| 21 | Temozolomide and whole brain irradiation in melanoma metastatic to the brain: a phase II trial of the Cytokine Working Group | Journal of Cancer Research and Clinical Oncology | 2002 | 134 |
| 22 | MET in Lung Cancer: Biomarker Selection Based on Scientific Rationale | Molecular Cancer Therapeutics | 2017 | 129 |
| 23 | Impact of care at comprehensive cancer centers on outcome: Results from a population‐based study | Cancer | 2015 | 124 |
| 24 | The Mitochondrion as an Emerging Therapeutic Target in Cancer | Trends in Molecular Medicine | 2020 | 121 |
| 25 | Multiple biomarker expression on circulating tumor cells in comparison to tumor tissues from primary and metastatic sites in patients with locally advanced/inflammatory, and stage IV breast cancer, using a novel detection technology | Breast Cancer Research and Treatment | 2011 | 117 |
| 26 | Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents | Blood | 1992 | 112 |
| 27 | Survival Outcomes of Metaplastic Breast Cancer Patients: Results from a US Population-based Analysis | Annals of Surgical Oncology | 2015 | 110 |
| 28 | Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents | Blood | 1992 | 108 |
| 29 | Phase I trial of continuous infusion 5-aza-2′-deoxycytidine | Cancer Chemotherapy and Pharmacology | 2003 | 107 |
| 30 | Randomized Double-Blind Phase II Study of Maintenance Pembrolizumab Versus Placebo After First-Line Chemotherapy in Patients With Metastatic Urothelial Cancer | Journal of Clinical Oncology | 2020 | 102 |
| 31 | Factors associated with high burden in caregivers of older adults with cancer | Cancer | 2014 | 101 |
| 32 | Selenium-dependent glutathione peroxidase-GI is a major glutathione peroxidase activity in the mucosal epithelium of rodent intestine1Portions of this work were presented in the Selenium II minisymposia at Experimental Biology '96. Preliminary accounts of this work appear in the proceedings volumes of the Sixth International Symposium on Selenium in Biology and Medicine (ISSBM, 1996) and The Japanese Society of Chromatography (1996).1 | Biochimica Et Biophysica Acta - General Subjects | 1998 | 99 |
| 33 | Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications | Free Radical Biology and Medicine | 1996 | 98 |
| 34 | Biological, Clinical, and Psychosocial Correlates at the Interface of Cancer and Aging Research | Journal of the National Cancer Institute | 2012 | 98 |
| 35 | Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis | Cancer Chemotherapy and Pharmacology | 2000 | 93 |
| 36 | The improbable targeted therapy: KRAS as an emerging target in non-small cell lung cancer (NSCLC) | Cell Reports Medicine | 2021 | 90 |
| 37 | Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential | Clinical and Experimental Metastasis | 1997 | 89 |
| 38 | Piwi-Interacting RNAs (piRNAs) Are Dysregulated in Renal Cell Carcinoma and Associated with Tumor Metastasis and Cancer-Specific Survival | Molecular Medicine | 2015 | 88 |
| 39 | FAK and paxillin, two potential targets in pancreatic cancer | Oncotarget | 2016 | 88 |
| 40 | Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma | Cancer Biology and Therapy | 2018 | 86 |
| 41 | Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase* | Gene | 1994 | 85 |
| 42 | Mapping of Copper/Hydrogen Peroxide-induced DNA Damage at Nucleotide Resolution in Human Genomic DNA by Ligation-mediated Polymerase Chain Reaction | Journal of Biological Chemistry | 1995 | 85 |
| 43 | Current and Future Management of Malignant Mesothelioma: A Consensus Report from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation | Journal of Thoracic Oncology | 2018 | 85 |
| 44 | Non-viral precision T cell receptor replacement for personalized cell therapy | Nature | 2023 | 85 |
| 45 | SARC009: Phase 2 study of dasatinib in patients with previously treated, high‐grade, advanced sarcoma | Cancer | 2016 | 80 |
| 46 | Global geriatric oncology: Achievements and challenges | Journal of Geriatric Oncology | 2017 | 76 |
| 47 | Reactivity of Plasma Glutathione Peroxidase with Hydroperoxide Substrates and Glutathione | Archives of Biochemistry and Biophysics | 1993 | 75 |
| 48 | Geriatric assessment-driven intervention (GAIN) on chemotherapy toxicity in older adults with cancer: A randomized controlled trial. | Journal of Clinical Oncology | 2020 | 75 |
| 49 | The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53 | Cancer Research | 2003 | 75 |
| 50 | Dolastatin-10 in metastatic melanoma: a phase II and pharmokinetic trial of the California Cancer Consortium | Investigational New Drugs | 2001 | 74 |
