| # | Title | Journal | Year | Citations |
|---|
| 1 | A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells | Nucleic Acids Research | 1991 | 2,268 |
| 2 | Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents | Pediatrics | 2017 | 2,199 |
| 3 | Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death | Nature | 2005 | 2,005 |
| 4 | Regulation of cardiac hypertrophy by intracellular signalling pathways | Nature Reviews Molecular Cell Biology | 2006 | 1,680 |
| 5 | Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases | Nature | 2019 | 1,638 |
| 6 | The Clinical Importance of the Metabolite Equol—A Clue to the Effectiveness of Soy and Its Isoflavones | Journal of Nutrition | 2002 | 980 |
| 7 | Human susceptibility and resistance to Norwalk virus infection | Nature Medicine | 2003 | 956 |
| 8 | Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis | New England Journal of Medicine | 2010 | 906 |
| 9 | Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death | Nature Cell Biology | 2007 | 837 |
| 10 | Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease | Nature Medicine | 2008 | 833 |
| 11 | FXR is a molecular target for the effects of vertical sleeve gastrectomy | Nature | 2014 | 810 |
| 12 | Eosinophilic gastrointestinal disorders (EGID)☆ | Journal of Allergy and Clinical Immunology | 2004 | 804 |
| 13 | The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6 | Journal of Biological Chemistry | 2000 | 767 |
| 14 | Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis | Journal of Clinical Investigation | 2006 | 750 |
| 15 | c-kit+ cells minimally contribute cardiomyocytes to the heart | Nature | 2014 | 723 |
| 16 | Coproduction of healthcare service | BMJ Quality and Safety | 2016 | 713 |
| 17 | Predicting Preschooler Obesity at Birth: The Role of Maternal Obesity in Early Pregnancy | Pediatrics | 2004 | 690 |
| 18 | Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women | American Journal of Clinical Nutrition | 1994 | 680 |
| 19 | Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy | Circulation Research | 2004 | 660 |
| 20 | Sickle cell disease | Lancet, The | 2017 | 639 |
| 21 | Fabry's disease | Lancet, The | 2008 | 628 |
| 22 | Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2012 | 624 |
| 23 | The Outcome of Neutrophil Gelatinase-Associated Lipocalin-Positive Subclinical Acute Kidney Injury | Journal of the American College of Cardiology | 2011 | 597 |
| 24 | Temporally Regulated and Tissue-Specific Gene Manipulations in the Adult and Embryonic Heart Using a Tamoxifen-Inducible Cre Protein | Circulation Research | 2001 | 593 |
| 25 | Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update | Clinical Pharmacology and Therapeutics | 2014 | 586 |
| 26 | The syndrome of pancreatic insufficiency and bone marrow dysfunction | Journal of Pediatrics | 1964 | 576 |
| 27 | An etiological role for aeroallergens and eosinophils in experimental esophagitis | Journal of Clinical Investigation | 2001 | 567 |
| 28 | Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis | Lancet Psychiatry,the | 2017 | 565 |
| 29 | Bicuspid aortic valve is heritable | Journal of the American College of Cardiology | 2004 | 560 |
| 30 | PKC-α regulates cardiac contractility and propensity toward heart failure | Nature Medicine | 2004 | 551 |
| 31 | Nitric oxide dioxygenase: An enzymic function for flavohemoglobin | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 529 |
| 32 | Phenotype, diagnosis, and treatment of Gaucher's disease | Lancet, The | 2008 | 518 |
| 33 | Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability | American Journal of Clinical Nutrition | 2002 | 516 |
| 34 | IL-13 receptors and signaling pathways: An evolving web | Journal of Allergy and Clinical Immunology | 2003 | 516 |
| 35 | Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children | Pediatrics | 2011 | 481 |
| 36 | Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation | Circulation | 2010 | 478 |
| 37 | Age-Specific Reference Intervals for Indexed Left Ventricular Mass in Children | Journal of the American Society of Echocardiography | 2009 | 475 |
| 38 | Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation | Thorax | 2012 | 466 |
| 39 | Executive Summary: Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2012 | 444 |
| 40 | Molecular basis of physiological heart growth: fundamental concepts and new players | Nature Reviews Molecular Cell Biology | 2013 | 439 |
| 41 | Hypoplastic Left Heart Syndrome | Journal of the American College of Cardiology | 2012 | 433 |
| 42 | Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling | Circulation Research | 2007 | 428 |
| 43 | Management of Ingested Foreign Bodies in Children | Journal of Pediatric Gastroenterology and Nutrition | 2015 | 426 |
| 44 | Calcineurin?NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs | Cardiovascular Research | 2004 | 403 |
| 45 | Equol: History, Chemistry, and Formation | Journal of Nutrition | 2010 | 398 |
| 46 | IL-13 involvement in eosinophilic esophagitis: Transcriptome analysis and reversibility with glucocorticoids | Journal of Allergy and Clinical Immunology | 2007 | 395 |
| 47 | An acute immune response underlies the benefit of cardiac stem cell therapy | Nature | 2020 | 392 |
| 48 | Targeting eosinophils in allergy, inflammation and beyond | Nature Reviews Drug Discovery | 2013 | 391 |
| 49 | Fabry disease revisited: Management and treatment recommendations for adult patients | Molecular Genetics and Metabolism | 2018 | 391 |
| 50 | Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability | Circulation Research | 2006 | 384 |
