| # | Title | Journal | Year | Citations |
|---|
| 1 | Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial | Lancet, The | 2016 | 1,570 |
| 2 | Adjuvant nivolumab versus ipilimumab in resected stage IIIB–C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trial | Lancet Oncology, The | 2020 | 330 |
| 3 | Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial | Lancet Oncology, The | 2018 | 170 |
| 4 | A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation | Cancer Chemotherapy and Pharmacology | 2013 | 164 |
| 5 | The stromal compartments in pancreatic cancer: Are there any therapeutic targets? | Cancer Letters | 2014 | 155 |
| 6 | Changes in shoulder muscle size and activity following treatment for breast cancer | Breast Cancer Research and Treatment | 2007 | 139 |
| 7 | The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation | Journal of Neuroinflammation | 2011 | 137 |
| 8 | Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP | Cancer Cell | 2013 | 136 |
| 9 | Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: a multicenter cohort study | Endocrine-Related Cancer | 2019 | 114 |
| 10 | A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours | British Journal of Cancer | 2011 | 113 |
| 11 | Directed Phenotype Switching as an Effective Antimelanoma Strategy | Cancer Cell | 2013 | 109 |
| 12 | A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer | Scientific Reports | 2015 | 109 |
| 13 | Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer | Cell Metabolism | 2018 | 92 |
| 14 | Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis | Gastroenterology | 2021 | 87 |
| 15 | Three-dimensional scapulothoracic motion following treatment for breast cancer | Breast Cancer Research and Treatment | 2009 | 86 |
| 16 | Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis | European Journal of Cancer | 2017 | 81 |
| 17 | Toxicities associated with checkpoint inhibitors—an overview | Rheumatology | 2019 | 80 |
| 18 | Drug radiotherapy combinations: Review of previous failures and reasons for future optimism | Cancer Treatment Reviews | 2015 | 78 |
| 19 | Implications of polygenic risk for personalised colorectal cancer screening | Annals of Oncology | 2016 | 76 |
| 20 | Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer | International Journal of Cancer | 2017 | 76 |
| 21 | First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity | European Journal of Cancer | 2019 | 76 |
| 22 | Randomized phase II study evaluating veliparib (ABT-888) with temozolomide in patients with metastatic melanoma | Annals of Oncology | 2015 | 74 |
| 23 | Retrospective audit of 957 consecutive 18F-FDG PET–CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma | Clinical Sarcoma Research | 2018 | 72 |
| 24 | A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours | British Journal of Cancer | 2017 | 69 |
| 25 | VCAM‐1‐targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis | FASEB Journal | 2011 | 66 |
| 26 | Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade | EMBO Molecular Medicine | 2018 | 64 |
| 27 | Clinical Characteristics and Outcomes in Patients with COVID-19 and Cancer: a Systematic Review and Meta-analysis | Clinical Oncology | 2021 | 61 |
| 28 | A multidisciplinary approach to giant cell tumors of tendon sheath and synovium—A critical appraisal of literature and treatment proposal | Journal of Surgical Oncology | 2013 | 60 |
| 29 | Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer | British Journal of Cancer | 2016 | 57 |
| 30 | The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence | Nucleic Acids Research | 2015 | 55 |
| 31 | Has the survival of patients with glioblastoma changed over the years? | British Journal of Cancer | 2016 | 54 |
| 32 | Harnessing Pandemonium: The Clinical Implications of Tumor Heterogeneity in Ovarian Cancer | Frontiers in Oncology | 2015 | 52 |
| 33 | Quality of life after non-surgical treatment of anal carcinoma: a case control study of long-term survivors | Clinical Oncology | 2004 | 50 |
| 34 | Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors | Annals of Oncology | 2013 | 42 |
| 35 | Anti-PD-L1 atezolizumab-Induced Autoimmune Diabetes: a Case Report and Review of the Literature | Targeted Oncology | 2017 | 40 |
| 36 | Consumption of omega‐3 fatty acids and the risk of skin cancers: A systematic review and meta‐analysis | International Journal of Cancer | 2014 | 39 |
| 37 | Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications | Seminars in Cancer Biology | 2022 | 39 |
| 38 | Glial Activation in the Early Stages of Brain Metastasis: TSPO as a Diagnostic Biomarker | Journal of Nuclear Medicine | 2014 | 38 |
| 39 | Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution | Molecular Cell | 2020 | 38 |
| 40 | Variation at 2q35 (PNKDandTMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease | Human Molecular Genetics | 2016 | 37 |
| 41 | Intermittent dosing with vemurafenib in BRAF V600E-mutant melanoma: review of a case series | Therapeutic Advances in Medical Oncology | 2014 | 36 |
| 42 | Initial Results from the Royal College of Radiologists' UK National Audit of Anal Cancer Radiotherapy 2015 | Clinical Oncology | 2017 | 35 |
| 43 | IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer | British Journal of Cancer | 2017 | 35 |
| 44 | Manual and automated Cu-mediated radiosynthesis of the PARP inhibitor [18F]olaparib | Nature Protocols | 2020 | 34 |
| 45 | The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study | Annals of Oncology | 2007 | 30 |
| 46 | The prognostic value of derived neutrophil to lymphocyte ratio in oesophageal cancer treated with definitive chemoradiotherapy | Radiotherapy and Oncology | 2017 | 30 |
| 47 | White matter structure and myelin-related gene expression alterations with experience in adult rats | Progress in Neurobiology | 2020 | 30 |
| 48 | Evaluation of Antitumor Activity Using Change in Tumor Size of the Survivin Antisense Oligonucleotide LY2181308 in Combination with Docetaxel for Second-Line Treatment of Patients with Non–Small-Cell Lung Cancer: A Randomized Open-Label Phase II Study | Journal of Thoracic Oncology | 2014 | 29 |
| 49 | 'Toxgnostics': an unmet need in cancer medicine | Nature Reviews Cancer | 2014 | 29 |
| 50 | Close temporal coupling of neuronal activity and tissue oxygen responses in rodent whisker barrel cortex | European Journal of Neuroscience | 2011 | 28 |
