| # | Title | Journal | Year | Citations |
|---|
| 1 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 1,503 |
| 2 | Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium | Lancet Infectious Diseases, The | 2019 | 970 |
| 3 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 | Critical Care Medicine | 2021 | 927 |
| 4 | Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research | European Respiratory Journal | 2017 | 253 |
| 5 | Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021 | Critical Care Medicine | 2021 | 209 |
| 6 | Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method | Critical Care | 2021 | 121 |
| 7 | Causes of Death on Antiretroviral Therapy: A Post-Mortem Study from South Africa | PLoS ONE | 2012 | 115 |
| 8 | Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function | Journal of Immunology Research | 2014 | 98 |
| 9 | Emergence of OXA-48 and OXA-181 Carbapenemases among Enterobacteriaceae in South Africa and Evidence of In Vivo Selection of Colistin Resistance as a Consequence of Selective Decontamination of the Gastrointestinal Tract | Journal of Clinical Microbiology | 2013 | 94 |
| 10 | Fluid administration for acute circulatory dysfunction using basic monitoring: narrative review and expert panel recommendations from an ESICM task force | Intensive Care Medicine | 2019 | 80 |
| 11 | Patient and family engagement in the ICU: Report from the task force of the World Federation of Societies of Intensive and Critical Care Medicine | Journal of Critical Care | 2018 | 76 |
| 12 | Overview of Community-Acquired Pneumonia and the Role of Inflammatory Mechanisms in the Immunopathogenesis of Severe Pneumococcal Disease | Mediators of Inflammation | 2013 | 75 |
| 13 | The changing treatment landscape in haemophilia: from standard half-life clotting factor concentrates to gene editing | Lancet, The | 2021 | 71 |
| 14 | Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A | Blood | 2016 | 69 |
| 15 | Variations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study | Lancet Respiratory Medicine,the | 2021 | 66 |
| 16 | South African guideline for the management of community-acquired pneumonia in adults | Journal of Thoracic Disease | 2017 | 63 |
| 17 | Defining extended half‐life rFVIII—A critical review of the evidence | Haemophilia | 2018 | 62 |
| 18 | From guidelines to practice: a pharmacist-driven prospective audit and feedback improvement model for peri-operative antibiotic prophylaxis in 34 South African hospitals | Journal of Antimicrobial Chemotherapy | 2016 | 58 |
| 19 | HIV-Associated Bacterial Pneumonia | Clinics in Chest Medicine | 2013 | 48 |
| 20 | Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus genotype 5 or 6 infection (ENDURANCE-5,6): an open-label, multicentre, phase 3b trial | The Lancet Gastroenterology and Hepatology | 2019 | 48 |
| 21 | Effectiveness of the 13-valent pneumococcal conjugate vaccine against invasive pneumococcal disease in South African children: a case-control study | The Lancet Global Health | 2017 | 47 |
| 22 | Core Outcomes Set for Trials in People With Coronavirus Disease 2019 | Critical Care Medicine | 2020 | 47 |
| 23 | Epidemiology, virulence factors and management of the pneumococcus | F1000Research | 2016 | 45 |
| 24 | Community-Acquired Pneumonia | Chest | 2015 | 44 |
| 25 | Recombinant factor VIII Fc fusion protein for the treatment of severe haemophilia A: Final results from the ASPIRE extension study | Haemophilia | 2020 | 44 |
| 26 | Recent advances in our understanding of Streptococcus pneumoniae infection | F1000prime Reports | 2014 | 43 |
| 27 | Multicomponent antibiotic substances produced by fermentation: Implications for regulatory authorities, critically ill patients and generics | International Journal of Antimicrobial Agents | 2014 | 42 |
| 28 | HIV Infection and the Epidemiology of Invasive Pneumococcal Disease (IPD) in South African Adults and Older Children Prior to the Introduction of a Pneumococcal Conjugate Vaccine (PCV) | PLoS ONE | 2016 | 40 |
| 29 | Epidemiology of lower respiratory tract infections in adults | Expert Review of Respiratory Medicine | 2019 | 38 |
| 30 | COVID-19 and Sepsis | Turkish Journal of Medical Sciences | 2021 | 37 |
| 31 | Impact of HIV infection and smoking on lung immunity and related disorders | European Respiratory Journal | 2015 | 36 |
| 32 | International Surviving Sepsis Campaign guidelines 2016: the perspective from low-income and middle-income countries | Lancet Infectious Diseases, The | 2017 | 36 |
| 33 | Bacteraemic Pneumococcal Pneumonia | Drugs | 2011 | 35 |
| 34 | The Durban World Congress Ethics Round Table Conference Report: I. Differences between withholding and withdrawing life-sustaining treatments | Journal of Critical Care | 2014 | 35 |
| 35 | Circulating Concentrations of the Novel Adipokine Chemerin Are Associated with Cardiovascular Disease Risk in Rheumatoid Arthritis | Journal of Rheumatology | 2014 | 34 |
| 36 | Multifaceted Role of Pneumolysin in the Pathogenesis of Myocardial Injury in Community-Acquired Pneumonia | International Journal of Molecular Sciences | 2018 | 34 |
| 37 | A pharmacist-led prospective antibiotic stewardship intervention improves compliance to community-acquired pneumonia guidelines in 39 public and private hospitals across South Africa | International Journal of Antimicrobial Agents | 2020 | 34 |
| 38 | The Durban World Congress Ethics Round Table Conference Report: II. Withholding or withdrawing of treatment in elderly patients admitted to the intensive care unit | Journal of Critical Care | 2014 | 32 |
| 39 | The Durban World Congress Ethics Round Table Conference Report: III. Withdrawing Mechanical ventilation—the approach should be individualized | Journal of Critical Care | 2014 | 32 |
| 40 | Bronchiectasis: New Approaches to Diagnosis and Management | Clinics in Chest Medicine | 2011 | 31 |
| 41 | Obesity and carotid atherosclerosis in African black and Caucasian women with established rheumatoid arthritis: a cross-sectional study | Arthritis Research and Therapy | 2012 | 31 |
| 42 | Low‐factor consumption for major surgery in haemophilia B with long‐acting recombinant glycoPEGylated factor IX | Haemophilia | 2017 | 31 |
| 43 | Pneumolysin as a potential therapeutic target in severe pneumococcal disease | Journal of Infection | 2017 | 31 |
| 44 | Outcomes in patients with community-acquired pneumonia admitted to the intensive care unit | Respiratory Medicine | 2015 | 29 |
| 45 | Extended half‐life clotting factor concentrates: results from published clinical trials | Haemophilia | 2016 | 29 |
| 46 | Long-term safety and efficacy of taliglucerase alfa in pediatric Gaucher disease patients who were treatment-naïve or previously treated with imiglucerase | Blood Cells, Molecules, and Diseases | 2018 | 29 |
| 47 | Comparison of outcomes in HIV-positive and HIV-negative patients with COVID-19 | Journal of Infection | 2021 | 29 |
| 48 | Retinol Binding Protein 4 Concentrations Relate to Enhanced Atherosclerosis in Obese Patients with Rheumatoid Arthritis | PLoS ONE | 2014 | 27 |
| 49 | Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis | Peptides | 2018 | 26 |
| 50 | Review manuscript: Mechanisms of platelet activation by the pneumococcus and the role of platelets in community-acquired pneumonia | Journal of Infection | 2017 | 25 |
