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Top Articles

#TitleJournalYearCitations
1A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2Science2020964
2The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell functionBiomaterials2010854
3Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 PatientsCell Host and Microbe2020811
4Ferroptosis and Its Role in Diverse Brain DiseasesMolecular Neurobiology2019319
5Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed miceBiomaterials2011313
6In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High EfficacyACS Nano2010304
7Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniaeCell Metabolism2019294
8Meningeal lymphatic vessels regulate brain tumor drainage and immunityCell Research2020209
9Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophagesCancer Letters2020200
10CXCL1–CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltrationEuropean Heart Journal2018192
11Brain control of humoral immune responses amenable to behavioural modulationNature2020167
12NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injuryProceedings of the National Academy of Sciences of the United States of America2015165
13Hypoxia inducible factor as a therapeutic target for atherosclerosisProceedings of the National Academy of Sciences of the United States of America2018154
14CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3pJournal of Experimental and Clinical Cancer Research2019151
15Carbon dots with red-shifted photoluminescence by fluorine doping for optical bio-imagingCarbon2018147
16Architecture of a SARS-CoV-2 mini replication and transcription complexNature Communications2020147
17Sestrin2 promotes LKB1‐mediated AMPK activation in the ischemic heartFASEB Journal2015143
18miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathyMolecular and Cellular Endocrinology2014136
19NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injuryProceedings of the National Academy of Sciences of the United States of America2018128
20Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s diseaseJournal of Neuroinflammation2020127
21Hydrogen sulfide contributes to cardioprotection during ischemia–reperfusion injury by opening KATPchannelsCanadian Journal of Physiology and Pharmacology2007125
22Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cellsJournal of Cellular Physiology2012124
23Elevated Expression of IL-33 and TSLP in the Airways of Human Asthmatics In Vivo: A Potential Biomarker of Severe Refractory DiseaseJournal of Immunology2018122
24H2A.Z facilitates licensing and activation of early replication originsNature2020119
25Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammationCardiovascular Research2014110
26IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial CellsEBioMedicine2018109
27The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen speciesBiomaterials2010108
28Transport of active flavonoids, based on cytotoxicity and lipophilicity: An evaluation using the blood–brain barrier cell and Caco-2 cell modelsToxicology in Vitro2014106
29Resveratrol protects human keratinocytes HaCaT cells from UVA-induced oxidative stress damage by downregulating Keap1 expressionEuropean Journal of Pharmacology2011104
30Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet–Induced Obesity and Insulin Resistance by Inhibiting LipolysisDiabetes2017104
31Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and SubmucosaJournal of Immunology2018101
32Hydrothermal synthesis of nitrogen-doped carbon dots with real-time live-cell imaging and blood–brain barrier penetration capabilitiesInternational Journal of Nanomedicine201699
33MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagyMolecular Cancer201598
34Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neuronsAutophagy202198
35Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysisNature Communications202198
36Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cellsCell Death and Disease201396
37Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cellsBiomedicine and Pharmacotherapy201694
38LncRNA H19 contributes to hippocampal glial cell activation via JAK/STAT signaling in a rat model of temporal lobe epilepsyJournal of Neuroinflammation201893
39Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microgliaJournal of Neuroinflammation201791
40CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancerScientific Reports201785
41Vaccination with a Paramyosin-Based Multi-Epitope Vaccine Elicits Significant Protective Immunity against Trichinella spiralis Infection in MiceFrontiers in Microbiology201785
42Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesisJournal of Clinical Investigation201884
43Prognostic role of pretreatment circulating MDSCs in patients with solid malignancies: A meta-analysis of 40 studiesOncoImmunology201883
44Clinical Significance of Baseline Neutrophil-to-Lymphocyte Ratio in Patients With Ischemic Stroke or Hemorrhagic Stroke: An Updated Meta-AnalysisFrontiers in Neurology201981
45Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancerNature Communications202079
46mRNAsi Index: Machine Learning in Mining Lung Adenocarcinoma Stem Cell BiomarkersGenes202079
47Oral vaccination with Ts87 DNA vaccine delivered by attenuated Salmonella typhimurium elicits a protective immune response against Trichinella spiralis larval challengeVaccine201077
48Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathwaysApoptosis: an International Journal on Programmed Cell Death201477
49Sertoli Cells Are Susceptible to ZIKV Infection in Mouse TestisFrontiers in Cellular and Infection Microbiology201776
50Adeno-associated virus 2 bound to its cellular receptor AAVRNature Microbiology201976