| # | Title | Journal | Year | Citations |
|---|
| 1 | Up-Regulation of Phosphorylated/Activated p70 S6 Kinase and Its Relationship to Neurofibrillary Pathology in Alzheimer's Disease | American Journal of Pathology | 2003 | 294 |
| 2 | Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages | Cancer Letters | 2020 | 200 |
| 3 | CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p | Journal of Experimental and Clinical Cancer Research | 2019 | 151 |
| 4 | Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease | Journal of Neuroinflammation | 2020 | 127 |
| 5 | Antitumor Peptides from Marine Organisms | Marine Drugs | 2011 | 123 |
| 6 | The Adverse Effects of Sorafenib in Patients with Advanced Cancers | Basic and Clinical Pharmacology and Toxicology | 2015 | 123 |
| 7 | Transport of active flavonoids, based on cytotoxicity and lipophilicity: An evaluation using the blood–brain barrier cell and Caco-2 cell models | Toxicology in Vitro | 2014 | 106 |
| 8 | Hydrothermal synthesis of nitrogen-doped carbon dots with real-time live-cell imaging and blood–brain barrier penetration capabilities | International Journal of Nanomedicine | 2016 | 99 |
| 9 | MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy | Molecular Cancer | 2015 | 98 |
| 10 | Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells | Biomedicine and Pharmacotherapy | 2016 | 94 |
| 11 | Higher specificity of the activity of low molecular weight fucoidan for thrombin-induced platelet aggregation | Thrombosis Research | 2010 | 93 |
| 12 | The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism | Cell Metabolism | 2014 | 92 |
| 13 | Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia | Journal of Neuroinflammation | 2017 | 91 |
| 14 | CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer | Scientific Reports | 2017 | 85 |
| 15 | Induction of cell proliferation and survival genes by estradiol-repressed microRNAs in breast cancer cells | BMC Cancer | 2012 | 80 |
| 16 | miR‐125b regulates the proliferation of glioblastoma stem cells by targeting E2F2 | FEBS Letters | 2012 | 77 |
| 17 | MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways | British Journal of Cancer | 2013 | 77 |
| 18 | Clove Extract Inhibits Tumor Growth and Promotes Cell Cycle Arrest and Apoptosis | Oncology Research | 2014 | 77 |
| 19 | Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats | Neuroscience | 2007 | 76 |
| 20 | What is the association of hypothyroidism with risks of cardiovascular events and mortality? A meta-analysis of 55 cohort studies involving 1,898,314 participants | BMC Medicine | 2017 | 74 |
| 21 | Metabolism of Peptide Drugs and Strategies to Improve their Metabolic Stability | Current Drug Metabolism | 2018 | 64 |
| 22 | Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice | International Journal of Biological Macromolecules | 2018 | 63 |
| 23 | Low Molecular Weight Fucoidan against Renal Ischemia–Reperfusion Injury via Inhibition of the MAPK Signaling Pathway | PLoS ONE | 2013 | 60 |
| 24 | Species identification of Mycobacterium abscessus subsp. abscessus and Mycobacterium abscessus subsp. bolletii using rpoB and hsp65, and susceptibility testing to eight antibiotics | International Journal of Infectious Diseases | 2014 | 57 |
| 25 | Knockdown of CXCR4 Inhibits CXCL12-Induced Angiogenesis in HUVECs through Downregulation of the MAPK/ERK and PI3K/AKT and the Wnt/β-Catenin Pathways | Cancer Investigation | 2018 | 56 |
| 26 | Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic–mass spectrometry and the application to pharmacokinetics in rats | Journal of Pharmaceutical and Biomedical Analysis | 2010 | 55 |
| 27 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway | Acta Pharmaceutica Sinica B | 2021 | 55 |
| 28 | The ability of hydroxysafflor yellow a to attenuate lipopolysaccharide‐induced pulmonary inflammatory injury in mice | Phytotherapy Research | 2010 | 53 |
| 29 | Hydroxysafflor Yellow A Alleviates Early Inflammatory Response of Bleomycin-Induced Mice Lung Injury | Biological and Pharmaceutical Bulletin | 2012 | 50 |
| 30 | Maslinic acid induces autophagy by down‐regulating HSPA8 in pancreatic cancer cells | Phytotherapy Research | 2018 | 50 |
| 31 | Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia/reperfusion hearts | Basic Research in Cardiology | 2019 | 49 |
| 32 | Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis | Nature Communications | 2021 | 48 |
| 33 | Low-molecular-weight fucoidan protects endothelial function and ameliorates basal hypertension in diabetic Goto-Kakizaki rats | Laboratory Investigation | 2014 | 47 |
| 34 | SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis | Cardiovascular Drugs and Therapy | 2022 | 47 |
| 35 | Chemopreventive effect of Myricetin, a natural occurring compound, on colonic chronic inflammation and inflammation-driven tumorigenesis in mice | Biomedicine and Pharmacotherapy | 2018 | 46 |
| 36 | Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts | Cell Death and Disease | 2022 | 46 |
| 37 | Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang | Journal of Pharmaceutical and Biomedical Analysis | 2007 | 44 |
| 38 | Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats | Journal of Pharmacy and Pharmacology | 2010 | 43 |
| 39 | Retrograde regulation of STIM1-Orai1 interaction and store-operated Ca2+ entry by calsequestrin | Scientific Reports | 2015 | 42 |
| 40 | Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism | Life Sciences | 2016 | 42 |
| 41 | Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells | Tumor Biology | 2015 | 41 |
| 42 | Cytotoxicity of the compounds isolated fromPulsatilla chinensissaponins and apoptosis induced by 23-hydroxybetulinic acid | Pharmaceutical Biology | 2015 | 41 |
| 43 | Exosomes-coated bcl-2 siRNA inhibits the growth of digestive system tumors both in vitro and in vivo | International Journal of Biological Macromolecules | 2020 | 41 |
| 44 | Bis(2,3-dibromo-4,5-dihydroxybenzyl) Ether, a Marine Algae Derived Bromophenol, Inhibits the Growth of Botrytis cinerea and Interacts with DNA Molecules | Marine Drugs | 2014 | 38 |
| 45 | Microwave-assisted polyol synthesis of carbon nitride dots from folic acid for cell imaging | International Journal of Nanomedicine | 2014 | 38 |
| 46 | Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function | Scientific Reports | 2017 | 37 |
| 47 | Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway | Drug Design, Development and Therapy | 2015 | 36 |
| 48 | Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Human Cancer Cells through Reactive Oxygen Species-Mediated NF-κB Activations | ACS Applied Materials & Interfaces | 2016 | 36 |
| 49 | Oridonin derivatives as potential anticancer drug candidates triggering apoptosis through mitochondrial pathway in the liver cancer cells | European Journal of Medicinal Chemistry | 2019 | 36 |
| 50 | Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation | Oncology Reports | 2016 | 34 |
