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Top Articles

#TitleJournalYearCitations
1New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation ProceduresDrug Metabolism Reviews2003248
2Comprehensive comparison of three different animal models for systemic inflammationJournal of Biomedical Science2017166
3Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing ratsArchives of Toxicology1997151
4Comparison of immunoreactive score, HER2/neu score and H score for the immunohistochemical evaluation of somatostatin receptors in bronchopulmonary neuroendocrine neoplasmsHistopathology2015123
5Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodiesBritish Journal of Pharmacology2011118
6Differentiation of Opioid Drug Effects by Hierarchical Multi-Site PhosphorylationMolecular Pharmacology2013113
7Adverse drug reactions in Germany: direct costs of internal medicine hospitalizationsPharmacoepidemiology and Drug Safety2011102
8Fate of extrahepatic human stem and precursor cells after transplantation into mouse liversHepatology200792
9Self-Medication with Over-the-Counter and Prescribed Drugs Causing Adverse-Drug-Reaction-Related Hospital Admissions: Results of a Prospective, Long-Term Multi-Centre StudyDrug Safety201485
10CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneuronsDevelopment (Cambridge)201468
11Asymmetrical (ADMA) and symmetrical dimethylarginine (SDMA) as potential risk factors for cardiovascular and renal outcome in chronic kidney disease – possible candidates for paradoxical epidemiology?Amino Acids200665
12Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agentsEuropean Journal of Medicinal Chemistry201459
13Influence of high-dose methotrexate therapy (HD-MTX) on glomerular and tubular kidney functionMedical and Pediatric Oncology200357
14Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slicesToxicology200156
15The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamideToxicology Letters200656
16Suitability of 5/6 nephrectomy (5/6NX) for the induction of interstitial renal fibrosis in rats – Influence of sex, strain, and surgical procedureExperimental and Toxicologic Pathology200655
17MK2/3 Are Pivotal for IL-33–Induced and Mast Cell–Dependent Leukocyte Recruitment and the Resulting Skin InflammationJournal of Immunology201654
18Hierarchical Organization of Multi-Site Phosphorylation at the CXCR4 C TerminusPLoS ONE201352
19Correlations between spin equilibrium shift, reduction rate, and N-demethylation activity in liver microsomal cytochrome P-450 and a series of benzphetamine analogues as substratesBiochemical Pharmacology198348
20The hepatic gluthathione system — influences of xenobioticsExperimental Pathology199048
21Lipid peroxidation in thioacetamide-induced macronodular rat liver cirrhosisArchives of Toxicology199147
22Heterologous regulation of agonist‐independent μ‐opioid receptor phosphorylation by protein kinase CBritish Journal of Pharmacology201445
23Loss of Morphine Reward and Dependence in Mice Lacking G Protein–Coupled Receptor Kinase 5Biological Psychiatry201445
24Phenotypic and Genotypic Characterization of Carcinomas of the Papilla of Vater Has Prognostic and Putative Therapeutic ImplicationsAmerican Journal of Clinical Pathology201144
25Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic systemDevelopment (Cambridge)201444
26Differential Expression of Somatostatin Receptor Subtype 1–5 Proteins in Numerous Human Normal TissuesExperimental and Clinical Endocrinology and Diabetes201243
27CXC Chemokine Receptor 7 (CXCR7) Regulates CXCR4 Protein Expression and Capillary Tuft Development in Mouse KidneyPLoS ONE201240
28Beneficial effect of acetylcysteine on cisplatin nephrotoxicity in ratsJournal of Applied Toxicology199338
29Effects of vaporized perfluorohexane and partial liquid ventilation on regional distribution of alveolar damage in experimental lung injuryIntensive Care Medicine200738
30Determination of the glomerular filtration rate (GFR): methodological problems, age-dependence, consequences of various surgical interventions, and the influence of different drugs and toxic substancesPhysiological Research199938
31Glutathione synthesis and export in experimental liver cirrhosis induced by thioacetamide: Relations to ultrastructural changesExperimental Pathology198937
32Comparative nephrotoxicity of some antitumour-active platinum and ruthenium complexes in ratsJournal of Applied Toxicology199837
33Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer’s diseaseActa Neuropathologica201536
34Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonistsScience Signaling201936
35Enzymes of glutathione synthesis in dog skeletal muscles and their response to trainingActa Physiologica Scandinavica199335
36Monooxygenation, cytochrome P450-mRNA expression and other functions in precision-cut rat liver slicesExperimental and Toxicologic Pathology199835
37Intermediate Progenitors Facilitate Intracortical Progression of Thalamocortical Axons and Interneurons through CXCL12 Chemokine SignalingJournal of Neuroscience201535
38Rapid Dephosphorylation of G Protein-coupled Receptors by Protein Phosphatase 1β Is Required for Termination of β-Arrestin-dependent SignalingJournal of Biological Chemistry201134
39Application of cryopreserved precision-cut liver slices in pharmacotoxicology — principles, literature data and own investigations with special reference to CYP1A1-mRNA inductionExperimental and Toxicologic Pathology199833
40Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric originJournal of Cancer Research and Clinical Oncology201633
41Preventable ADRs leading to hospitalization — results of a long-term prospective safety study with 6,427 ADR cases focusing on elderly patientsExpert Opinion on Drug Safety201833
42Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell OntogenyCell Reports202033
43Comparative evaluation of three proliferation markers, Ki-67, TOP2A, and RacGAP1, in bronchopulmonary neuroendocrine neoplasms: Issues and prospectsOncotarget033
44Induction of cytochrome P450 2B1-mRNA and pentoxyresorufin O-depentylation after exposure of precision-cut rat liver slices to phenobarbitalToxicology200032
45A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)–p85 to Filamin A Negatively Controls the PI3K PathwayMolecular and Cellular Biology201232
46The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptorsJournal of Experimental Medicine201932
47Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic miceArthritis Research and Therapy201131
48CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrusHippocampus201331
49Cell-Autonomous Regulation of Mu-Opioid Receptor Recycling by Substance PCell Reports201530
50Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative DisordersJournal of Medicinal Chemistry201529