| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,224 |
| 3 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 4 | ESPEN guidelines on nutrition in cancer patients | Clinical Nutrition | 2017 | 1,855 |
| 5 | Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions | Nature Neuroscience | 2019 | 1,589 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 7 | European guideline for the diagnosis and treatment of insomnia | Journal of Sleep Research | 2017 | 1,334 |
| 8 | Reactive astrocyte nomenclature, definitions, and future directions | Nature Neuroscience | 2021 | 1,098 |
| 9 | Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution | Nature | 2019 | 853 |
| 10 | The impact of guidance on Internet-based mental health interventions — A systematic review | Internet Interventions | 2014 | 829 |
| 11 | Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity | Nature | 2020 | 818 |
| 12 | Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017 | Pharmacopsychiatry | 2018 | 787 |
| 13 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 14 | Dealing with sleep problems during home confinement due to the COVID‐19 outbreak: Practical recommendations from a task force of the European CBT‐I Academy | Journal of Sleep Research | 2020 | 688 |
| 15 | Mitochondrial Machineries for Protein Import and Assembly | Annual Review of Biochemistry | 2017 | 651 |
| 16 | Autophagy in major human diseases | EMBO Journal | 2021 | 615 |
| 17 | Insomnia as a predictor of mental disorders: A systematic review and meta-analysis | Sleep Medicine Reviews | 2019 | 614 |
| 18 | The target landscape of clinical kinase drugs | Science | 2017 | 609 |
| 19 | Innate immune memory in the brain shapes neurological disease hallmarks | Nature | 2018 | 605 |
| 20 | Diagnosis and management of spinal muscular atrophy: Part 1: Recommendations for diagnosis, rehabilitation, orthopedic and nutritional care | Neuromuscular Disorders | 2018 | 584 |
| 21 | Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation | Science | 2019 | 583 |
| 22 | Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis | Circulation Research | 2018 | 577 |
| 23 | Mitochondrial proteins: from biogenesis to functional networks | Nature Reviews Molecular Cell Biology | 2019 | 569 |
| 24 | Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma | Nature Medicine | 2019 | 541 |
| 25 | Antimicrobial photodynamic therapy – what we know and what we don’t | Critical Reviews in Microbiology | 2018 | 533 |
| 26 | GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines | BMJ, The | 2016 | 507 |
| 27 | Guidelines for the use of flow cytometry and cell sorting in immunological studies* | European Journal of Immunology | 2017 | 505 |
| 28 | Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread | Nature Microbiology | 2019 | 476 |
| 29 | ESPEN practical guideline: Clinical Nutrition in cancer | Clinical Nutrition | 2021 | 472 |
| 30 | A new fate mapping system reveals context-dependent random or clonal expansion of microglia | Nature Neuroscience | 2017 | 446 |
| 31 | ISCEV standard for clinical visual evoked potentials: (2016 update) | Documenta Ophthalmologica | 2016 | 445 |
| 32 | Radiotherapy toxicity | Nature Reviews Disease Primers | 2019 | 434 |
| 33 | The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee | Clinical Microbiology and Infection | 2017 | 428 |
| 34 | Diagnosis and management of spinal muscular atrophy: Part 2: Pulmonary and acute care; medications, supplements and immunizations; other organ systems; and ethics | Neuromuscular Disorders | 2018 | 421 |
| 35 | Microglia Heterogeneity in the Single-Cell Era | Cell Reports | 2020 | 421 |
| 36 | Taxonomy of the order Mononegavirales: update 2016 | Archives of Virology | 2016 | 407 |
| 37 | Consensus reclassification of inherited epidermolysis bullosa and other disorders with skin fragility | British Journal of Dermatology | 2020 | 406 |
| 38 | Physiology and role of irisin in glucose homeostasis | Nature Reviews Endocrinology | 2017 | 403 |
| 39 | The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity | Journal of Allergy and Clinical Immunology: in Practice | 2019 | 381 |
| 40 | Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper | JHEP Reports | 2020 | 378 |
| 41 | Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates | Nature Communications | 2019 | 369 |
| 42 | Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism | Cell | 2020 | 367 |
| 43 | Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline | Clinical Infectious Diseases | 2020 | 367 |
| 44 | Sleep, insomnia, and depression | Neuropsychopharmacology | 2020 | 364 |
| 45 | International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci | Nature Communications | 2019 | 363 |
| 46 | Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE | Nature Neuroscience | 2019 | 358 |
| 47 | Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline | Clinical Infectious Diseases | 2020 | 357 |
| 48 | Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes | Nature Genetics | 2018 | 356 |
| 49 | Antidepressant drugs act by directly binding to TRKB neurotrophin receptors | Cell | 2021 | 347 |
| 50 | Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale | Cell Reports | 2017 | 346 |
