# | Title | Journal | Year | Citations |
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1 | The Phosphoinositide 3-Kinase Pathway | Science | 2002 | 5,004 |
2 | PI3K: Downstream AKTion Blocks Apoptosis | Cell | 1997 | 1,580 |
3 | Large-scale characterization of HeLa cell nuclear phosphoproteins | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 1,434 |
4 | Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains | Science | 1997 | 1,329 |
5 | Signalling through the lipid products of phosphoinositide-3-OH kinase | Nature | 1997 | 1,290 |
6 | Targeting the PI3K-Akt pathway in human cancer | Cancer Cell | 2003 | 1,230 |
7 | Catalytic specificity of protein-tyrosine kinases is critical for selective signalling | Nature | 1995 | 932 |
8 | The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function | Journal of Biological Chemistry | 1999 | 897 |
9 | Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 744 |
10 | Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. | Journal of Clinical Investigation | 1998 | 637 |
11 | TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins | EMBO Journal | 2000 | 623 |
12 | The PX domains of p47phox and p40phox bind to lipid products of PI(3)K | Nature Cell Biology | 2001 | 567 |
13 | Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin A | Science | 1999 | 562 |
14 | Determination of protease cleavage site motifs using mixture-based oriented peptide libraries | Nature Biotechnology | 2001 | 524 |
15 | Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes | Journal of Biological Chemistry | 1997 | 516 |
16 | A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity | Nature Cell Biology | 2002 | 480 |
17 | A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate | Nature | 1997 | 448 |
18 | Rheb fills a GAP between TSC and TOR | Trends in Biochemical Sciences | 2003 | 443 |
19 | A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains | Journal of Biological Chemistry | 1997 | 420 |
20 | Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases | Nature | 1997 | 370 |
21 | Recognition and specificity in protein tyrosine kinase-mediated signalling | Trends in Biochemical Sciences | 1995 | 353 |
22 | Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α | Nature Genetics | 2000 | 273 |
23 | Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival | Molecular and Cellular Biology | 2002 | 254 |
24 | Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly | Current Biology | 2000 | 233 |
25 | United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling | Biochemical Society Transactions | 2003 | 204 |
26 | Phosphoinositide 3-Kinase Inhibition Spares Actin Assembly in Activating Platelets but Reverses Platelet Aggregation | Journal of Biological Chemistry | 1995 | 202 |
27 | SH2 domain specificity and activity modified by a single residue | Nature | 1994 | 199 |
28 | Phosphoinositide 3-kinase in immunological systems | Seminars in Immunology | 2002 | 193 |
29 | Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival | Cell | 2011 | 185 |
30 | Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin | Journal of Biological Chemistry | 1997 | 184 |
31 | The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor | Nature Structural and Molecular Biology | 2004 | 182 |
32 | The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120 | Journal of Biological Chemistry | 1995 | 178 |
33 | An Intramembrane Modulator of the ErbB2 Receptor Tyrosine Kinase That Potentiates Neuregulin Signaling | Journal of Biological Chemistry | 1999 | 176 |
34 | The Inositol 5′-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation | Journal of Biological Chemistry | 1996 | 166 |
35 | The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif | Journal of Biological Chemistry | 1995 | 165 |
36 | Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex | Molecular and Cellular Biology | 1998 | 164 |
37 | Subcellular Locations of Phosphatidylinositol 4-Kinase Isoforms | Journal of Biological Chemistry | 1997 | 163 |
38 | p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase | Journal of Biological Chemistry | 1996 | 161 |
39 | Cloning and Characterization of a Wortmannin-sensitive Human Phosphatidylinositol 4-Kinase | Journal of Biological Chemistry | 1997 | 149 |
40 | Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase β −/− Mice | Molecular and Cellular Biology | 2004 | 140 |
41 | Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 137 |
42 | Platelet-Derived Growth Factor-Dependent Activation of Phosphatidylinositol 3-Kinase Is Regulated by Receptor Binding of SH2-Domain-Containing Proteins Which Influence Ras Activity | Molecular and Cellular Biology | 1996 | 132 |
43 | Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3 | Journal of Biological Chemistry | 1995 | 131 |
44 | p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells | Journal of Biological Chemistry | 1996 | 128 |
45 | Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/Omi | Journal of Biological Chemistry | 2003 | 116 |
46 | Phosphatidylinositol 4,5-Bisphosphate Synthesis Is Required for Activation of Phospholipase D in U937 Cells | Journal of Biological Chemistry | 1995 | 114 |
47 | D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-Acetate | Journal of Biological Chemistry | 1996 | 113 |
48 | Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors | Journal of Biological Chemistry | 2001 | 113 |
49 | An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 112 |
50 | Ligand Discrimination in Signaling through an ErbB4 Receptor Homodimer | Journal of Biological Chemistry | 2000 | 104 |