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Top Articles

#TitleJournalYearCitations
1The Phosphoinositide 3-Kinase PathwayScience20025,004
2PI3K: Downstream AKTion Blocks ApoptosisCell19971,580
3Large-scale characterization of HeLa cell nuclear phosphoproteinsProceedings of the National Academy of Sciences of the United States of America20041,434
4Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ DomainsScience19971,329
5Signalling through the lipid products of phosphoinositide-3-OH kinaseNature19971,290
6Targeting the PI3K-Akt pathway in human cancerCancer Cell20031,230
7Catalytic specificity of protein-tyrosine kinases is critical for selective signallingNature1995932
8The Role of Phosphoinositide 3-Kinase Lipid Products in Cell FunctionJournal of Biological Chemistry1999897
9Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signalingProceedings of the National Academy of Sciences of the United States of America2002744
10Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.Journal of Clinical Investigation1998637
11TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteinsEMBO Journal2000623
12The PX domains of p47phox and p40phox bind to lipid products of PI(3)KNature Cell Biology2001567
13Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin AScience1999562
14Determination of protease cleavage site motifs using mixture-based oriented peptide librariesNature Biotechnology2001524
15Determination of the Specific Substrate Sequence Motifs of Protein Kinase C IsozymesJournal of Biological Chemistry1997516
16A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarityNature Cell Biology2002480
17A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphateNature1997448
18Rheb fills a GAP between TSC and TORTrends in Biochemical Sciences2003443
19A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology DomainsJournal of Biological Chemistry1997420
20Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinasesNature1997370
21Recognition and specificity in protein tyrosine kinase-mediated signallingTrends in Biochemical Sciences1995353
22Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85αNature Genetics2000273
23Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and SurvivalMolecular and Cellular Biology2002254
24Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assemblyCurrent Biology2000233
25United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signallingBiochemical Society Transactions2003204
26Phosphoinositide 3-Kinase Inhibition Spares Actin Assembly in Activating Platelets but Reverses Platelet AggregationJournal of Biological Chemistry1995202
27SH2 domain specificity and activity modified by a single residueNature1994199
28Phosphoinositide 3-kinase in immunological systemsSeminars in Immunology2002193
29Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell SurvivalCell2011185
30Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by WortmanninJournal of Biological Chemistry1997184
31The structural basis for substrate and inhibitor selectivity of the anthrax lethal factorNature Structural and Molecular Biology2004182
32The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120Journal of Biological Chemistry1995178
33An Intramembrane Modulator of the ErbB2 Receptor Tyrosine Kinase That Potentiates Neuregulin SignalingJournal of Biological Chemistry1999176
34The Inositol 5′-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor AggregationJournal of Biological Chemistry1996166
35The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY MotifJournal of Biological Chemistry1995165
36Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling ComplexMolecular and Cellular Biology1998164
37Subcellular Locations of Phosphatidylinositol 4-Kinase IsoformsJournal of Biological Chemistry1997163
38p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-KinaseJournal of Biological Chemistry1996161
39Cloning and Characterization of a Wortmannin-sensitive Human Phosphatidylinositol 4-KinaseJournal of Biological Chemistry1997149
40Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase β −/− MiceMolecular and Cellular Biology2004140
41Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3Proceedings of the National Academy of Sciences of the United States of America2002137
42Platelet-Derived Growth Factor-Dependent Activation of Phosphatidylinositol 3-Kinase Is Regulated by Receptor Binding of SH2-Domain-Containing Proteins Which Influence Ras ActivityMolecular and Cellular Biology1996132
43Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3Journal of Biological Chemistry1995131
44p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other CellsJournal of Biological Chemistry1996128
45Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/OmiJournal of Biological Chemistry2003116
46Phosphatidylinositol 4,5-Bisphosphate Synthesis Is Required for Activation of Phospholipase D in U937 CellsJournal of Biological Chemistry1995114
47D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-AcetateJournal of Biological Chemistry1996113
48Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB ReceptorsJournal of Biological Chemistry2001113
49An RBCC protein implicated in maintenance of steady-state neuregulin receptor levelsProceedings of the National Academy of Sciences of the United States of America2002112
50Ligand Discrimination in Signaling through an ErbB4 Receptor HomodimerJournal of Biological Chemistry2000104