| # | Title | Journal | Year | Citations |
|---|
| 1 | Adipose Tissue as an Endocrine Organ | Journal of Clinical Endocrinology and Metabolism | 2004 | 4,205 |
| 2 | Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase | Nature Medicine | 2002 | 3,692 |
| 3 | TLR4 links innate immunity and fatty acid–induced insulin resistance | Journal of Clinical Investigation | 2006 | 3,012 |
| 4 | Role of leptin in the neuroendocrine response to fasting | Nature | 1996 | 2,865 |
| 5 | Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres | Nature | 2002 | 2,232 |
| 6 | Adipocyte differentiation from the inside out | Nature Reviews Molecular Cell Biology | 2006 | 2,163 |
| 7 | Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase | Nature | 2002 | 1,823 |
| 8 | Leptin | Annual Review of Physiology | 2000 | 1,473 |
| 9 | Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States | Cell Metabolism | 2007 | 1,305 |
| 10 | A role for melanin-concentrating hormone in the central regulation of feeding behaviour | Nature | 1996 | 1,259 |
| 11 | Adipose Tissue as an Endocrine Organ | Trends in Endocrinology and Metabolism | 2000 | 1,238 |
| 12 | Adipogenesis and Obesity: Rounding Out the Big Picture | Cell | 1996 | 1,212 |
| 13 | Rapid, reversible activation of AgRP neurons drives feeding behavior in mice | Journal of Clinical Investigation | 2011 | 1,184 |
| 14 | Charting a dynamic DNA methylation landscape of the human genome | Nature | 2013 | 1,168 |
| 15 | Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice | Molecular and Cellular Biology | 2000 | 1,150 |
| 16 | Neuron-type-specific signals for reward and punishment in the ventral tegmental area | Nature | 2012 | 1,101 |
| 17 | Mice lacking melanin-concentrating hormone are hypophagic and lean | Nature | 1998 | 1,085 |
| 18 | Obesity Wars | Cell | 2004 | 1,043 |
| 19 | Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure | Cell | 2005 | 963 |
| 20 | Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance | Molecular Cell | 1998 | 901 |
| 21 | Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network | Science | 2007 | 841 |
| 22 | Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area | Neuron | 1999 | 817 |
| 23 | Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis | Neuron | 2004 | 817 |
| 24 | Ghrelin | Molecular Metabolism | 2015 | 810 |
| 25 | Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor | Journal of Biological Chemistry | 1997 | 759 |
| 26 | Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity | Journal of Clinical Investigation | 2000 | 750 |
| 27 | Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association | Thyroid | 2012 | 739 |
| 28 | Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord | Neuron | 1998 | 717 |
| 29 | Agouti-related peptide–expressing neurons are mandatory for feeding | Nature Neuroscience | 2005 | 663 |
| 30 | Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1 | Molecular Cell | 2001 | 661 |
| 31 | A guide to analysis of mouse energy metabolism | Nature Methods | 2012 | 655 |
| 32 | Human leptin levels are pulsatile and inversely related to pituitary–ardenal function | Nature Medicine | 1997 | 637 |
| 33 | A molecular census of arcuate hypothalamus and median eminence cell types | Nature Neuroscience | 2017 | 635 |
| 34 | BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis | Nature | 2003 | 630 |
| 35 | Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice | Endocrinology | 2004 | 628 |
| 36 | Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice | Neuron | 2003 | 603 |
| 37 | Understanding the Physiology of FGF21 | Annual Review of Physiology | 2016 | 590 |
| 38 | Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat | Nature Medicine | 2013 | 579 |
| 39 | The Role of SOCS-3 in Leptin Signaling and Leptin Resistance | Journal of Biological Chemistry | 1999 | 536 |
| 40 | Neuronal PTP1B regulates body weight, adiposity and leptin action | Nature Medicine | 2006 | 533 |
| 41 | Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis | Cell Metabolism | 2011 | 531 |
| 42 | An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger | Nature | 2014 | 526 |
| 43 | Leptin and reproduction: a review | Fertility and Sterility | 2002 | 515 |
| 44 | Transcriptional Control of Adipose Lipid Handling by IRF4 | Cell Metabolism | 2011 | 508 |
| 45 | AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1 | Molecular Cell | 2013 | 508 |
| 46 | The Role of Leptin in Human Obesity and Disease: A Review of Current Evidence | Annals of Internal Medicine | 1999 | 490 |
| 47 | Unraveling the central nervous system pathways underlying responses to leptin | Nature Neuroscience | 1998 | 478 |
| 48 | A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism | Nature | 2012 | 473 |
| 49 | Leptin in human physiology and pathophysiology | American Journal of Physiology - Endocrinology and Metabolism | 2011 | 458 |
| 50 | What’s in a Name? In Search of Leptin’s Physiologic Role1 | Journal of Clinical Endocrinology and Metabolism | 1998 | 441 |
