| # | Title | Journal | Year | Citations |
|---|
| 1 | Renal clearance of quantum dots | Nature Biotechnology | 2007 | 3,789 |
| 2 | EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib | New England Journal of Medicine | 2005 | 3,715 |
| 3 | Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping | Nature Biotechnology | 2004 | 2,011 |
| 4 | Randomized Phase II Study of Multiple Dose Levels of CCI-779, a Novel Mammalian Target of Rapamycin Kinase Inhibitor, in Patients With Advanced Refractory Renal Cell Carcinoma | Journal of Clinical Oncology | 2004 | 948 |
| 5 | Randomized Phase III Trial of High-Dose Interleukin-2 Versus Subcutaneous Interleukin-2 and Interferon in Patients With Metastatic Renal Cell Carcinoma | Journal of Clinical Oncology | 2005 | 746 |
| 6 | New Technologies for Human Cancer Imaging | Journal of Clinical Oncology | 2008 | 728 |
| 7 | Design considerations for tumour-targeted nanoparticles | Nature Nanotechnology | 2010 | 692 |
| 8 | The FLARE™ Intraoperative Near-Infrared Fluorescence Imaging System: A First-in-Human Clinical Trial in Breast Cancer Sentinel Lymph Node Mapping | Annals of Surgical Oncology | 2009 | 628 |
| 9 | Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex | Nature | 2009 | 620 |
| 10 | Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA | Molecular Cell | 2003 | 611 |
| 11 | The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease | Nature Reviews Molecular Cell Biology | 2007 | 606 |
| 12 | Rapid translocation of nanoparticles from the lung airspaces to the body | Nature Biotechnology | 2010 | 546 |
| 13 | Pin1-Dependent Prolyl Isomerization Regulates Dephosphorylation of Cdc25C and Tau Proteins | Molecular Cell | 2000 | 519 |
| 14 | EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications | Lancet Oncology, The | 2012 | 505 |
| 15 | 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport | Journal of Cell Biology | 2002 | 501 |
| 16 | RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer | Nature Communications | 2015 | 498 |
| 17 | Resistance to targeted therapy in renal-cell carcinoma | Lancet Oncology, The | 2009 | 496 |
| 18 | Efficacy, Safety, and Potential Biomarkers of Sunitinib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study | Journal of Clinical Oncology | 2009 | 467 |
| 19 | Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression | Journal of Immunology | 2008 | 462 |
| 20 | Targeted zwitterionic near-infrared fluorophores for improved optical imaging | Nature Biotechnology | 2013 | 459 |
| 21 | Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway | Cancer Cell | 2004 | 458 |
| 22 | Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC | Nature Cell Biology | 2001 | 447 |
| 23 | An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis | Cell | 2011 | 445 |
| 24 | BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations | PLoS Medicine | 2007 | 444 |
| 25 | A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response | Nature | 2012 | 430 |
| 26 | Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 403 |
| 27 | Imaging Sites of Receptor Dephosphorylation by PTP1B on the Surface of the Endoplasmic Reticulum | Science | 2002 | 401 |
| 28 | Carbonic Anhydrase IX Expression Predicts Outcome of Interleukin 2 Therapy for Renal Cancer | Clinical Cancer Research | 2005 | 401 |
| 29 | Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancers Dependent on the Epidermal Growth Factor Receptor Pathway | Clinical Lung Cancer | 2009 | 394 |
| 30 | In vivo near-infrared fluorescence imaging of osteoblastic activity | Nature Biotechnology | 2001 | 371 |
| 31 | Prevalent Overexpression of Prolyl Isomerase Pin1 in Human Cancers | American Journal of Pathology | 2004 | 347 |
| 32 | Pinning down proline-directed phosphorylation signaling | Trends in Cell Biology | 2002 | 334 |
| 33 | Effect of Injection Routes on the Biodistribution, Clearance, and Tumor Uptake of Carbon Dots | ACS Nano | 2013 | 332 |
| 34 | Evolving Strategies for the Management of Hand–Foot Skin Reaction Associated with the Multitargeted Kinase Inhibitors Sorafenib and Sunitinib | Oncologist | 2008 | 315 |
| 35 | The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins | Genes and Development | 1998 | 311 |
| 36 | Linking β-Catenin to Androgen-signaling Pathway | Journal of Biological Chemistry | 2002 | 308 |
| 37 | Synthesis and In Vivo Fate of Zwitterionic Near‐Infrared Fluorophores | Angewandte Chemie - International Edition | 2011 | 308 |
| 38 | Combined Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor (EGFR) Blockade Inhibits Tumor Growth in Xenograft Models of EGFR Inhibitor Resistance | Clinical Cancer Research | 2009 | 297 |
| 39 | Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma | Cancer | 2006 | 286 |
| 40 | Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots | Nano Letters | 2009 | 281 |
| 41 | Negative regulation of interferon-regulatory factor 3–dependent innate antiviral response by the prolyl isomerase Pin1 | Nature Immunology | 2006 | 280 |
| 42 | The Pin2/TRF1-Interacting Protein PinX1 Is a Potent Telomerase Inhibitor | Cell | 2001 | 274 |
| 43 | HIV‐associated plasmablastic lymphoma: Lessons learned from 112 published cases | American Journal of Hematology | 2008 | 266 |
| 44 | Atopy and asthma: genetic variants of IL-4 and IL-13 signalling | Trends in Immunology | 2000 | 265 |
| 45 | In Vivo Tracking of Stem Cells for Clinical Trials in Cardiovascular Disease | Circulation | 2004 | 264 |
| 46 | Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity | Blood | 2016 | 259 |
| 47 | Counselling framework for moderate-penetrance cancer-susceptibility mutations | Nature Reviews Clinical Oncology | 2016 | 258 |
| 48 | PIN1 Is an E2F Target Gene Essential for Neu / Ras -Induced Transformation of Mammary Epithelial Cells | Molecular and Cellular Biology | 2002 | 250 |
| 49 | An Alternative Inhibitor Overcomes Resistance Caused by a Mutation of the Epidermal Growth Factor Receptor | Cancer Research | 2005 | 250 |
| 50 | Image-Guided Oncologic Surgery Using Invisible Light: Completed Pre-Clinical Development for Sentinel Lymph Node Mapping | Annals of Surgical Oncology | 2006 | 249 |
