| # | Title | Journal | Year | Citations |
|---|
| 1 | Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury | Critical Care | 2013 | 969 |
| 2 | Animal Models of sepsis: setting the stage | Nature Reviews Drug Discovery | 2005 | 673 |
| 3 | Serum Lactate as a Predictor of Mortality in Emergency Department Patients with Infection | Annals of Emergency Medicine | 2005 | 637 |
| 4 | In-Hospital Cardiac Arrest | JAMA - Journal of the American Medical Association | 2019 | 544 |
| 5 | Mortality in Emergency Department Sepsis (MEDS) score: A prospectively derived and validated clinical prediction rule* | Critical Care Medicine | 2003 | 505 |
| 6 | Etiology and Therapeutic Approach to Elevated Lactate Levels | Mayo Clinic Proceedings | 2013 | 488 |
| 7 | MIMIC-CXR, a de-identified publicly available database of chest radiographs with free-text reports | Scientific Data | 2019 | 477 |
| 8 | Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update) | Otolaryngology - Head and Neck Surgery | 2017 | 466 |
| 9 | Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity | JAMA - Journal of the American Medical Association | 2021 | 458 |
| 10 | Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis | Intensive Care Medicine | 2008 | 414 |
| 11 | Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study | BMJ, The | 2022 | 393 |
| 12 | The glycocalyx: a novel diagnostic and therapeutic target in sepsis | Critical Care | 2019 | 385 |
| 13 | Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol* | Critical Care Medicine | 2006 | 378 |
| 14 | Spectrum of Dizziness Visits to US Emergency Departments: Cross-Sectional Analysis From a Nationally Representative Sample | Mayo Clinic Proceedings | 2008 | 339 |
| 15 | Learning a Health Knowledge Graph from Electronic Medical Records | Scientific Reports | 2017 | 263 |
| 16 | Annual Incidence of Adult and Pediatric In-Hospital Cardiac Arrest in the United States | Circulation: Cardiovascular Quality and Outcomes | 2019 | 243 |
| 17 | Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock | Critical Care Medicine | 2016 | 239 |
| 18 | Multicenter Study of Central Venous Oxygen Saturation (ScvO2) as a Predictor of Mortality in Patients With Sepsis | Annals of Emergency Medicine | 2010 | 236 |
| 19 | Frailty for Surgeons: Review of a National Institute on Aging Conference on Frailty for Specialists | Journal of the American College of Surgeons | 2015 | 229 |
| 20 | The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis | Critical Care | 2010 | 212 |
| 21 | Medical complications associated with earthquakes | Lancet, The | 2012 | 209 |
| 22 | A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis | Critical Care Medicine | 2009 | 208 |
| 23 | Creating an automated trigger for sepsis clinical decision support at emergency department triage using machine learning | PLoS ONE | 2017 | 208 |
| 24 | A comparison of physostigmine and benzodiazepines for the treatment of anticholinergic poisoning | Annals of Emergency Medicine | 2000 | 200 |
| 25 | Myths and Misconceptions of Wernicke’s Encephalopathy: What Every Emergency Physician Should Know | Annals of Emergency Medicine | 2007 | 198 |
| 26 | Who Needs a Blood Culture? A Prospectively Derived and Validated Prediction Rule | Journal of Emergency Medicine | 2008 | 197 |
| 27 | Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study | Critical Care Medicine | 2017 | 187 |
| 28 | Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock | JAMA - Journal of the American Medical Association | 2020 | 169 |
| 29 | Diagnosing Appendicitis: Evidence-Based Review of the Diagnostic Approach in 2014 | Western Journal of Emergency Medicine | 2014 | 165 |
| 30 | Time to Epinephrine and Survival After Pediatric In-Hospital Cardiac Arrest | JAMA - Journal of the American Medical Association | 2015 | 158 |
| 31 | Delirium Risk Prediction, Healthcare Use and Mortality of Elderly Adults in the Emergency Department | Journal of the American Geriatrics Society | 2014 | 157 |
| 32 | The prevalence and significance of abnormal vital signs prior to in-hospital cardiac arrest | Resuscitation | 2016 | 157 |
| 33 | Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability | Circulation | 2018 | 157 |
| 34 | Toxicity of energy drinks | Current Opinion in Pediatrics | 2012 | 155 |
| 35 | The microcirculation image quality score: Development and preliminary evaluation of a proposed approach to grading quality of image acquisition for bedside videomicroscopy | Journal of Critical Care | 2013 | 150 |
| 36 | Value of abdominal CT in the emergency department for patients with abdominal pain | European Radiology | 2003 | 149 |
| 37 | Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients | Resuscitation | 2007 | 149 |
| 38 | “Resuscitation time bias”—A unique challenge for observational cardiac arrest research | Resuscitation | 2018 | 149 |
| 39 | Effectiveness of Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccines for Preventing Coronavirus Disease 2019 Hospitalizations in the United States | Clinical Infectious Diseases | 2022 | 144 |
| 40 | The Effectiveness of Disaster Training for Health Care Workers: A Systematic Review | Annals of Emergency Medicine | 2008 | 141 |
| 41 | The Pharmacology and Toxicology of Atypical Antipsychotic Agents | Journal of Toxicology: Clinical Toxicology | 2001 | 138 |
| 42 | Predicting Adverse Outcomes in Syncope | Journal of Emergency Medicine | 2007 | 133 |
| 43 | Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA | Journal of Cell Science | 2017 | 131 |
| 44 | Diabetes and Sepsis: Preclinical Findings and Clinical Relevance | Diabetes Care | 2011 | 130 |
| 45 | Initial Lactate and Lactate Change in Post–Cardiac Arrest | Critical Care Medicine | 2014 | 128 |
| 46 | Reasons for death in patients successfully resuscitated from out-of-hospital and in-hospital cardiac arrest | Resuscitation | 2019 | 127 |
| 47 | Does This Patient Have Erythema Migrans? | JAMA - Journal of the American Medical Association | 2007 | 126 |
| 48 | Overreliance on Symptom Quality in Diagnosing Dizziness: Results of a Multicenter Survey of Emergency Physicians | Mayo Clinic Proceedings | 2007 | 125 |
| 49 | Diagnosis of acute neurological emergencies in pregnant and post-partum women | Lancet Neurology, The | 2013 | 125 |
| 50 | Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults | Critical Care | 2014 | 125 |
