# | Title | Journal | Year | Citations |
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1 | The basics of epithelial-mesenchymal transition | Journal of Clinical Investigation | 2009 | 8,252 |
2 | AKT/PKB Signaling: Navigating Downstream | Cell | 2007 | 5,261 |
3 | MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling | Science | 2007 | 4,187 |
4 | Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid | Science | 1983 | 3,557 |
5 | The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth | Nature | 2008 | 2,423 |
6 | The epithelial–mesenchymal transition: new insights in signaling, development, and disease | Journal of Cell Biology | 2006 | 1,819 |
7 | The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin | Science | 2005 | 1,704 |
8 | The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 1,561 |
9 | Large-scale characterization of HeLa cell nuclear phosphoproteins | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 1,434 |
10 | Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 1,258 |
11 | Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers | Nature Medicine | 2008 | 1,238 |
12 | Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses | Science | 2011 | 984 |
13 | Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin | Nature | 1990 | 935 |
14 | THE HIGH-AFFINITY IgE RECEPTOR (FcεRI): From Physiology to Pathology | Annual Review of Immunology | 1999 | 908 |
15 | EMT: When epithelial cells decide to become mesenchymal-like cells | Journal of Clinical Investigation | 2009 | 792 |
16 | Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor | Arthritis and Rheumatism | 2000 | 758 |
17 | ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect | Nature Cell Biology | 2012 | 693 |
18 | PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models withEGFRandERBB2Mutations that Are Resistant to Gefitinib | Cancer Research | 2007 | 674 |
19 | Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis | Nature Chemical Biology | 2012 | 614 |
20 | Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells | Science | 2010 | 586 |
21 | Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin A | Science | 1999 | 562 |
22 | SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction | Nature | 2011 | 558 |
23 | Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation | Science | 2013 | 555 |
24 | Determination of protease cleavage site motifs using mixture-based oriented peptide libraries | Nature Biotechnology | 2001 | 524 |
25 | Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes | Journal of Biological Chemistry | 1997 | 516 |
26 | AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1 | Molecular Cell | 2013 | 508 |
27 | Nitrate synthesis in the germfree and conventional rat | Science | 1981 | 498 |
28 | Targeting the PI3K signaling pathway in cancer | Current Opinion in Genetics and Development | 2010 | 494 |
29 | A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity | Nature Cell Biology | 2002 | 480 |
30 | Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases | Science | 1996 | 425 |
31 | OMERACT: An international initiative to improve outcome measurement in rheumatology | Trials | 2007 | 420 |
32 | Mapping Symptoms to Brain Networks with the Human Connectome | New England Journal of Medicine | 2018 | 416 |
33 | Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling | Cancer Cell | 2009 | 411 |
34 | The carcinogenic risk of treatments for severe psoriasis | Cancer | 1994 | 408 |
35 | Differential incorporation of fatty acids into and peroxidative loss of fatty acids from phospholipids of human spermatozoa | Molecular Reproduction and Development | 1995 | 397 |
36 | Heterogeneity of tumor-induced gene expression changes in the human metabolic network | Nature Biotechnology | 2013 | 381 |
37 | Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation | EMBO Journal | 1998 | 377 |
38 | Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases | Nature | 1997 | 370 |
39 | Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation | Science | 1993 | 357 |
40 | Sex Hormones in Acquired Immunity and Autoimmune Disease | Frontiers in Immunology | 2018 | 353 |
41 | The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 351 |
42 | Pathologic predictors of early local recurrence in stage I and II breast cancer treated by primary radiation therapy | Cancer | 1984 | 348 |
43 | Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation | Molecular Cell | 2009 | 318 |
44 | The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension | Journal of Neurology | 2017 | 311 |
45 | Mechanisms of metastasis: Epithelial-to-mesenchymal transition and contribution of tumor microenvironment | Journal of Cellular Biochemistry | 2007 | 306 |
46 | Combined Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor (EGFR) Blockade Inhibits Tumor Growth in Xenograft Models of EGFR Inhibitor Resistance | Clinical Cancer Research | 2009 | 297 |
47 | Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway | EMBO Journal | 2003 | 295 |
48 | Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males | Experientia | 1988 | 282 |
49 | National survey of hospital patients | BMJ: British Medical Journal | 1994 | 278 |
50 | Protein Sequences from Mastodon and Tyrannosaurus Rex Revealed by Mass Spectrometry | Science | 2007 | 273 |