721(top 1%)
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109(top 0.1%)
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Top Articles

#TitleJournalYearCitations
1The basics of epithelial-mesenchymal transitionJournal of Clinical Investigation20098,252
2AKT/PKB Signaling: Navigating DownstreamCell20075,261
3MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 SignalingScience20074,187
4Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluidScience19833,557
5The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growthNature20082,423
6The epithelial–mesenchymal transition: new insights in signaling, development, and diseaseJournal of Cell Biology20061,819
7The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of MetforminScience20051,704
8The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressProceedings of the National Academy of Sciences of the United States of America20041,561
9Large-scale characterization of HeLa cell nuclear phosphoproteinsProceedings of the National Academy of Sciences of the United States of America20041,434
10Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophreniaProceedings of the National Academy of Sciences of the United States of America20091,258
11Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancersNature Medicine20081,238
12Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant ResponsesScience2011984
13Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectinNature1990935
14THE HIGH-AFFINITY IgE RECEPTOR (FcεRI): From Physiology to PathologyAnnual Review of Immunology1999908
15EMT: When epithelial cells decide to become mesenchymal-like cellsJournal of Clinical Investigation2009792
16Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factorArthritis and Rheumatism2000758
17ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effectNature Cell Biology2012693
18PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models withEGFRandERBB2Mutations that Are Resistant to GefitinibCancer Research2007674
19Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesisNature Chemical Biology2012614
20Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating CellsScience2010586
21Affinity-Driven Peptide Selection of an NFAT Inhibitor More Selective Than Cyclosporin AScience1999562
22SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destructionNature2011558
23Influence of Threonine Metabolism on S -Adenosylmethionine and Histone MethylationScience2013555
24Determination of protease cleavage site motifs using mixture-based oriented peptide librariesNature Biotechnology2001524
25Determination of the Specific Substrate Sequence Motifs of Protein Kinase C IsozymesJournal of Biological Chemistry1997516
26AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1Molecular Cell2013508
27Nitrate synthesis in the germfree and conventional ratScience1981498
28Targeting the PI3K signaling pathway in cancerCurrent Opinion in Genetics and Development2010494
29A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarityNature Cell Biology2002480
30Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family KinasesScience1996425
31OMERACT: An international initiative to improve outcome measurement in rheumatologyTrials2007420
32Mapping Symptoms to Brain Networks with the Human ConnectomeNew England Journal of Medicine2018416
33Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K SignalingCancer Cell2009411
34The carcinogenic risk of treatments for severe psoriasisCancer1994408
35Differential incorporation of fatty acids into and peroxidative loss of fatty acids from phospholipids of human spermatozoaMolecular Reproduction and Development1995397
36Heterogeneity of tumor-induced gene expression changes in the human metabolic networkNature Biotechnology2013381
37Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activationEMBO Journal1998377
38Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinasesNature1997370
39Interaction of Shc with the zeta chain of the T cell receptor upon T cell activationScience1993357
40Sex Hormones in Acquired Immunity and Autoimmune DiseaseFrontiers in Immunology2018353
41The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolismProceedings of the National Academy of Sciences of the United States of America2010351
42Pathologic predictors of early local recurrence in stage I and II breast cancer treated by primary radiation therapyCancer1984348
43Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell ProliferationMolecular Cell2009318
44The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertensionJournal of Neurology2017311
45Mechanisms of metastasis: Epithelial-to-mesenchymal transition and contribution of tumor microenvironmentJournal of Cellular Biochemistry2007306
46Combined Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor (EGFR) Blockade Inhibits Tumor Growth in Xenograft Models of EGFR Inhibitor ResistanceClinical Cancer Research2009297
47Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathwayEMBO Journal2003295
48Aberrant protamine 1/protamine 2 ratios in sperm of infertile human malesExperientia1988282
49National survey of hospital patientsBMJ: British Medical Journal1994278
50Protein Sequences from Mastodon and Tyrannosaurus Rex Revealed by Mass SpectrometryScience2007273