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| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 1.7K |
| Integrating response shift into health-related quality of life research: a theoretical model | Social Science and Medicine | 1999 | 1.5K |
| Multifractality in human heartbeat dynamics | Nature | 1999 | 1.2K |
| Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons | Neuron | 1999 | 1.1K |
| Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus | Journal of Bone and Mineral Research | 1999 | 1K |
| From lesions to leptin: hypothalamic control of food intake and body weight | Neuron | 1999 | 993 |
| Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group | Journal of Clinical Oncology | 1999 | 839 |
| The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology | Annual Review of Immunology | 1999 | 825 |
| The role of phosphoinositide 3-kinase lipid products in cell function | Journal of Biological Chemistry | 1999 | 786 |
| Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns | European Journal of Neuroscience | 1999 | 775 |
| Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area | Neuron | 1999 | 735 |
| Chemotherapy-induced anemia in adults: incidence and treatment | Journal of the National Cancer Institute | 1999 | 703 |
| Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance | Nature Medicine | 1999 | 658 |
| The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein | Nature | 1999 | 606 |
| Function of WW domains as phosphoserine- or phosphothreonine-binding modules | Science | 1999 | 591 |
| The ischemic penumbra: operationally defined by diffusion and perfusion MRI | Neurology | 1999 | 588 |
| Methodological approaches for assessing response shift in longitudinal health-related quality-of-life research | Social Science and Medicine | 1999 | 584 |
| Signalling through the high-affinity IgE receptor Fc epsilonRI | Nature | 1999 | 571 |
| Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes | Diabetes | 1999 | 557 |
| Are guidelines following guidelines? The methodological quality of clinical practice guidelines in the peer-reviewed medical literature | JAMA - Journal of the American Medical Association | 1999 | 549 |
| Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial | JAMA - Journal of the American Medical Association | 1999 | 545 |
| Statistical properties of the volatility of price fluctuations | Physical Review E | 1999 | 545 |
| Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance | Nature Medicine | 1999 | 529 |
| The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 500 |
