| # | Title | Journal | Year | Citations |
|---|
| 1 | Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases | Science | 2002 | 3,738 |
| 2 | A comprehensive classification system for lipids | Journal of Lipid Research | 2005 | 1,348 |
| 3 | Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors | Nature | 1997 | 1,201 |
| 4 | Guidelines and definitions for research on epithelial–mesenchymal transition | Nature Reviews Molecular Cell Biology | 2020 | 1,195 |
| 5 | ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression | Nature | 2006 | 851 |
| 6 | Signal transduction and endocytosis: close encounters of many kinds | Nature Reviews Molecular Cell Biology | 2002 | 763 |
| 7 | Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors | Science | 1995 | 746 |
| 8 | Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia | Biological Psychiatry | 1995 | 630 |
| 9 | Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation | Hippocampus | 1992 | 616 |
| 10 | Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2 | Nature | 2006 | 609 |
| 11 | Adenylyl cyclases and the interaction between calcium and cAMP signalling | Nature | 1995 | 571 |
| 12 | Early Pulmonary Inflammation in Infants with Cystic Fibrosis | American Journal of Respiratory and Critical Care Medicine | 1995 | 545 |
| 13 | Drosophila OBP LUSH Is Required for Activity of Pheromone-Sensitive Neurons | Neuron | 2005 | 544 |
| 14 | Mixed-lineage kinase control of JNK and p38 MAPK pathways | Nature Reviews Molecular Cell Biology | 2002 | 519 |
| 15 | Sublimation as a method of matrix application for mass spectrometric imaging | Journal of the American Society for Mass Spectrometry | 2007 | 514 |
| 16 | Differential Regulation of EGF Receptor Internalization and Degradation by Multiubiquitination within the Kinase Domain | Molecular Cell | 2006 | 471 |
| 17 | Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase | Journal of Biological Chemistry | 1997 | 440 |
| 18 | Analysis of Clathrin-mediated Endocytosis of Epidermal Growth Factor Receptor by RNA Interference | Journal of Biological Chemistry | 2004 | 397 |
| 19 | Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes | Nature Cell Biology | 2001 | 388 |
| 20 | Multiple Ionic Conductances of the Human Dopamine Transporter: The Actions of Dopamine and Psychostimulants | Journal of Neuroscience | 1997 | 387 |
| 21 | Ethanol sensitivity of the GABAA receptor expressed in xenopus oocytes requires 8 amino acids contained in the γ2L subunit | Neuron | 1991 | 357 |
| 22 | Cyclic AMP Promotes Neuronal Survival by Phosphorylation of Glycogen Synthase Kinase 3β | Molecular and Cellular Biology | 2000 | 352 |
| 23 | Exposing rats to a predator impairs spatial working memory in the radial arm water maze | Hippocampus | 1999 | 350 |
| 24 | Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock | Nature Cell Biology | 2003 | 346 |
| 25 | Photoswitchable cyan fluorescent protein for protein tracking | Nature Biotechnology | 2004 | 345 |
| 26 | Structural Insights into Histone Demethylation by JMJD2 Family Members | Cell | 2006 | 341 |
| 27 | Glycogen Synthase Kinase-3 Phosphorylates Bax and Promotes Its Mitochondrial Localization during Neuronal Apoptosis | Journal of Neuroscience | 2004 | 340 |
| 28 | Induction of hippocampal long-term potentiation using physiologically patterned stimulation | Neuroscience Letters | 1986 | 336 |
| 29 | Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats | Brain Research | 1993 | 336 |
| 30 | Synaptic Potentials Mediated via α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons | Journal of Neuroscience | 1998 | 322 |
| 31 | Nonimmunological production of leukotrienes induced by platelet-activating factor | Science | 1982 | 319 |
| 32 | Glial Cell Line-Derived Neurotrophic Factor Protects against Ischemia-Induced Injury in the Cerebral Cortex | Journal of Neuroscience | 1997 | 309 |
| 33 | Tissue Plasminogen Activator Induction in Purkinje Neurons After Cerebellar Motor Learning | Science | 1995 | 307 |
| 34 | The molecular properties and applications of Anthozoa fluorescent proteins and chromoproteins | Nature Biotechnology | 2004 | 307 |
| 35 | beta1- and beta2-Adrenergic receptors in rat cerebral cortex are independently regulated | Science | 1979 | 303 |
| 36 | Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy | Current Biology | 2000 | 292 |
| 37 | Mechanisms of the epithelial–mesenchymal transition by TGF-β | Future Oncology | 2009 | 290 |
| 38 | Casein Kinase I | Cellular Signalling | 1998 | 288 |
| 39 | Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons | Journal of Comparative Neurology | 1995 | 284 |
| 40 | Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits | Molecular Biology of the Cell | 2003 | 283 |
| 41 | Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor | Nature | 1979 | 267 |
| 42 | Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 265 |
| 43 | Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution | PLoS Biology | 2004 | 263 |
| 44 | Cyclic Nucleotide–Gated Channels Colocalize with Adenylyl Cyclase in Regions of Restricted Camp Diffusion | Journal of General Physiology | 2000 | 257 |
| 45 | Chronic and acute regulation of Na+/Cl–-dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems | | 2001 | 253 |
| 46 | Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4. | Journal of Biological Chemistry | 1988 | 249 |
| 47 | Nicotinic Receptor Function in Schizophrenia | Schizophrenia Bulletin | 1996 | 243 |
| 48 | beta-Adrenergic receptor involvement in 6-hydroxydopamine-induced supersensitivity in rat cerebral cortex | Science | 1976 | 239 |
| 49 | Myocardial-Directed Overexpression of the Human β1-Adrenergic Receptor in Transgenic Mice | Journal of Molecular and Cellular Cardiology | 2000 | 239 |
| 50 | Insulin as a potent, specific growth factor in a rat hepatoma cell line | Science | 1981 | 237 |
