| # | Title | Journal | Year | Citations |
|---|
| 1 | Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure | New England Journal of Medicine | 2004 | 5,193 |
| 2 | β-Adrenergic Receptor Blockade in Chronic Heart Failure | Circulation | 2000 | 953 |
| 3 | THE CARDIAC FIBROBLAST: Therapeutic Target in Myocardial Remodeling and Failure | Annual Review of Pharmacology and Toxicology | 2005 | 589 |
| 4 | Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium. | Journal of Clinical Investigation | 1997 | 455 |
| 5 | Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy | Lancet, The | 1993 | 411 |
| 6 | Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure | American Journal of Cardiology | 1999 | 275 |
| 7 | Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle | American Journal of Physiology - Endocrinology and Metabolism | 2000 | 275 |
| 8 | Association of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock | JAMA - Journal of the American Medical Association | 2020 | 260 |
| 9 | Dose-response of chronic beta-blocker treatment in heart failure from either idiopathic dilated or ischemic cardiomyopathy. Bucindolol Investigators. | Circulation | 1994 | 257 |
| 10 | Altered Beta-adrenergic Receptor Gene Regulation and Signaling in Chronic Heart Failure | Journal of Molecular and Cellular Cardiology | 2001 | 251 |
| 11 | Canonical Transient Receptor Potential Channels Promote Cardiomyocyte Hypertrophy through Activation of Calcineurin Signaling | Journal of Biological Chemistry | 2006 | 251 |
| 12 | Altered Ca2+ Responses in Muscles with Combined Mitochondrial and Cytosolic Creatine Kinase Deficiencies | Cell | 1997 | 250 |
| 13 | Myocardial-Directed Overexpression of the Human β1-Adrenergic Receptor in Transgenic Mice | Journal of Molecular and Cellular Cardiology | 2000 | 239 |
| 14 | Reduced beta 1 receptor messenger RNA abundance in the failing human heart. | Journal of Clinical Investigation | 1993 | 229 |
| 15 | Active muscle and whole body lactate kinetics after endurance training in men | Journal of Applied Physiology | 1999 | 222 |
| 16 | Beta-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure | Journal of the American College of Cardiology | 2002 | 220 |
| 17 | Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure | Journal of Lipid Research | 2007 | 219 |
| 18 | Drug Therapy in the Heart Transplant Recipient | Circulation | 2004 | 200 |
| 19 | Health Status and Clinical Practice | Circulation | 2002 | 195 |
| 20 | Dose-Related Effects of Methadone on QT Prolongation in a Series of Patients with Torsade de Pointes | Pharmacotherapy | 2003 | 195 |
| 21 | PGC-1α and ERRα target gene downregulation is a signature of the failing human heart | Journal of Molecular and Cellular Cardiology | 2009 | 184 |
| 22 | Depression and Cardiovascular Disease | Circulation | 2005 | 181 |
| 23 | Thiol Antioxidants Inhibit the Adjuvant Effects of Aerosolized Diesel Exhaust Particles in a Murine Model for Ovalbumin Sensitization | Journal of Immunology | 2002 | 178 |
| 24 | Regulation of Thyroid Hormone Receptor Isoforms in Physiological and Pathological Cardiac Hypertrophy | Circulation Research | 2001 | 177 |
| 25 | Changes in myocardial and vascular receptors in heart failure | Journal of the American College of Cardiology | 1993 | 175 |
| 26 | Usefulness of Enalapril Versus Propranolol or Atenolol for Prevention of Aortic Dilation in Patients With the Marfan Syndrome | American Journal of Cardiology | 2005 | 161 |
| 27 | Platelet Function Studies in Coronary Artery Disease | Circulation | 1973 | 158 |
| 28 | Drug Therapy in the Heart Transplant Recipient | Circulation | 2004 | 153 |
| 29 | A high-stringency blueprint of the human proteome | Nature Communications | 2020 | 152 |
| 30 | Cardiac adrenergic receptor effects of carvedilol | European Heart Journal | 1996 | 148 |
| 31 | The veterans affairs continuous improvement in cardiac surgery study | Annals of Thoracic Surgery | 1994 | 147 |
| 32 | Regulation of the mRNA-binding Protein AUF1 by Activation of the β -Adrenergic Receptor Signal Transduction Pathway | Journal of Biological Chemistry | 1996 | 145 |
| 33 | Evaluation of exercise and training on muscle lipid metabolism | American Journal of Physiology - Endocrinology and Metabolism | 1999 | 145 |
| 34 | Cardiac β-Adrenergic Neuroeffector Systems in Acute Myocardial Dysfunction Related to Brain Injury | Circulation | 1995 | 140 |
| 35 | Dilated Cardiomyopathy Associated With Deficiency of the Cytoskeletal Protein Metavinculin | Circulation | 1997 | 140 |
| 36 | Why does the myocardium fail? Insights from basic science | Lancet, The | 1998 | 139 |
| 37 | Selective Downregulation of the Angiotensin II AT 1 -Receptor Subtype in Failing Human Ventricular Myocardium | Circulation | 1997 | 138 |
| 38 | Electrophysiological effects of acute ventricular dilatation in the isolated rabbit heart. | Circulation Research | 1988 | 137 |
| 39 | Pathophysiologic and pharmacologic rationales for clinical management of chronic heart failure with beta-blocking agents | American Journal of Cardiology | 1993 | 134 |
| 40 | Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented α‐adrenergic vasoconstriction | Journal of Physiology | 2001 | 133 |
| 41 | AKAP-Lbc Mobilizes a Cardiac Hypertrophy Signaling Pathway | Molecular Cell | 2008 | 129 |
| 42 | Altered Platelet Function in Patients with Prosthetic Mitral Valves Effects of Sulfinpyrazone Therapy | Circulation | 1970 | 128 |
| 43 | Combined Oral Positive Inotropic and Beta-Blocker Therapy for Treatment of Refractory Class IV Heart Failure | Journal of the American College of Cardiology | 1998 | 126 |
| 44 | Effect of a Collaborative Care Intervention vs Usual Care on Health Status of Patients With Chronic Heart Failure | JAMA Internal Medicine | 2018 | 123 |
| 45 | Signaling Pathways Responsible for Fetal Gene Induction in the Failing Human Heart | Circulation | 2001 | 122 |
| 46 | Right Bundle-Branch Block Associated with Left Superior or Inferior Intraventricular Block | Circulation | 1970 | 112 |
| 47 | Operation Everest II: Cardiac filling pressures during cycle exercise at sea level | Respiration Physiology | 1990 | 112 |
| 48 | Endurance training increases gluconeogenesis during rest and exercise in men | American Journal of Physiology - Endocrinology and Metabolism | 2000 | 111 |
| 49 | Drug Therapy in the Heart Transplant Recipient | Circulation | 2005 | 111 |
| 50 | Adult lung side population cells have mesenchymal stem cell potential | Cytotherapy | 2008 | 105 |
