| # | Title | Journal | Year | Citations |
|---|
| 1 | Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation | Pharmaceutical Research | 2003 | 1,179 |
| 2 | Rational design of stable lyophilized protein formulations: some practical advice | Pharmaceutical Research | 1997 | 592 |
| 3 | Calpain activation in apoptosis | Journal of Cellular Physiology | 1994 | 425 |
| 4 | Infrared Spectroscopic Studies of Lyophilization‐ and Temperature‐Induced Protein Aggregation | Journal of Pharmaceutical Sciences | 1995 | 416 |
| 5 | Surface-Induced Denaturation of Proteins during Freezing and its Inhibition by Surfactants | Journal of Pharmaceutical Sciences | 1996 | 399 |
| 6 | NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger | Molecular Pharmacology | 2004 | 395 |
| 7 | The Clinical Pharmacokinetics of Levofloxacin | Clinical Pharmacokinetics | 1997 | 386 |
| 8 | Physical Activity in U.S. Adults With Diabetes and At Risk for Developing Diabetes, 2003 | Diabetes Care | 2007 | 373 |
| 9 | Reactions of 4-hydroxynonenal with proteins and cellular targets | Free Radical Biology and Medicine | 2004 | 349 |
| 10 | The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature‐controlled shelf | Journal of Pharmaceutical Sciences | 2001 | 315 |
| 11 | Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor | Protein Science | 2003 | 311 |
| 12 | Obesity, Inactivity, and the Prevalence of Diabetes and Diabetes-Related Cardiovascular Comorbidities in the U.S., 2000-2002 | Diabetes Care | 2005 | 294 |
| 13 | Nosocomial Infections Due to Multidrug-ResistantPseudomonas aeruginosa: Epidemiology and Treatment Options | Pharmacotherapy | 2005 | 289 |
| 14 | Role of Human Aldehyde Dehydrogenases in Endobiotic and Xenobiotic Metabolism | Drug Metabolism Reviews | 2004 | 269 |
| 15 | Mechanisms of drug-induced liver injury | AAPS Journal | 2006 | 249 |
| 16 | Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues11This work is dedicated to the memory of Professor Lars Ernster, who provided us with enthusiastic support, scientific insight, and constant encouragement in our many interactions. | Free Radical Biology and Medicine | 2000 | 248 |
| 17 | The Hepatocellular Metabolism of 4-Hydroxynonenal by Alcohol Dehydrogenase, Aldehyde Dehydrogenase, and Glutathione S-Transferase | Archives of Biochemistry and Biophysics | 1995 | 243 |
| 18 | Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions | Journal of Pharmaceutical Sciences | 1998 | 242 |
| 19 | Effects of Tween 20® and Tween 80® on the Stability of Albutropin During Agitation | Journal of Pharmaceutical Sciences | 2005 | 242 |
| 20 | Annealing to optimize the primary drying rate, reduce freezing‐induced drying rate heterogeneity, and determine T'g in pharmaceutical lyophilization | Journal of Pharmaceutical Sciences | 2001 | 241 |
| 21 | Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase | Pharmacological Reviews | 2007 | 241 |
| 22 | Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells | Oncogene | 2003 | 216 |
| 23 | l‐Type amino acid transporter 1 inhibitors inhibit tumor cell growth | Cancer Science | 2010 | 216 |
| 24 | Rational Design of Stable Lyophilized Protein Formulations: Theory and Practice | Pharmaceutical Biotechnology | 2002 | 214 |
| 25 | Anticancer potential of silymarin: from bench to bed side | Anticancer Research | 2006 | 210 |
| 26 | A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults | Journal of Clinical Epidemiology | 2004 | 204 |
| 27 | Effect of tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII | Journal of Pharmaceutical Sciences | 1998 | 200 |
| 28 | Milk Thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from Silybum marianum on Antiproliferative End Points in Human Prostate Carcinoma Cells | Cancer Research | 2005 | 194 |
| 29 | Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis | Clinical Cancer Research | 2002 | 192 |
| 30 | Oxidative Dimer Formation Is the Critical Rate-Limiting Step for Parkinson's Disease α-Synuclein Fibrillogenesis† | Biochemistry | 2003 | 186 |
| 31 | BSA Degradation Under Acidic Conditions: A Model For Protein Instability During Release From PLGA Delivery Systems | Journal of Pharmaceutical Sciences | 2006 | 183 |
| 32 | Safety and efficacy of unfractionated heparin versus enoxaparin in patients who are obese and patients with severe renal impairment: analysis from the ESSENCE and TIMI 11B studies | American Heart Journal | 2003 | 181 |
| 33 | Studies of the Structure of Insulin Fibrils by Fourier Transform Infrared (FTIR) Spectroscopy and Electron Microscopy | Journal of Pharmaceutical Sciences | 2001 | 176 |
| 34 | Aggregation of Granulocyte Colony Stimulating Factor under Physiological Conditions: Characterization and Thermodynamic Inhibition† | Biochemistry | 2002 | 175 |
| 35 | A mechanism of paraquat toxicity involving nitric oxide synthase | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 173 |
| 36 | Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3 | International Journal of Cancer | 2004 | 172 |
| 37 | DT-diaphorase in activation and detoxification of quinones | Cancer and Metastasis Reviews | 1993 | 168 |
| 38 | A Genomic and Proteomic Analysis of Activation of the Human Neutrophil by Lipopolysaccharide and Its Mediation by p38 Mitogen-activated Protein Kinase | Journal of Biological Chemistry | 2002 | 166 |
| 39 | Quinone Reductases Multitasking in the Metabolic World | Drug Metabolism Reviews | 2004 | 165 |
| 40 | Polymers Protect Lactate Dehydrogenase during Freeze-Drying by Inhibiting Dissociation in the Frozen State | Archives of Biochemistry and Biophysics | 1996 | 164 |
| 41 | Modification of Heat Shock Protein 90 by 4-Hydroxynonenal in a Rat Model of Chronic Alcoholic Liver Disease | Journal of Pharmacology and Experimental Therapeutics | 2005 | 163 |
| 42 | Practical quantitative biomedical applications of MALDI-TOF mass spectrometry | Journal of the American Society for Mass Spectrometry | 2002 | 160 |
| 43 | Infrared and Circular Dichroism Spectroscopic Characterization of Structural Differences between β-Lactoglobulin A and B | Biochemistry | 1996 | 159 |
| 44 | Therapeutic ultrasound: Its application in drug delivery | Medicinal Research Reviews | 2002 | 158 |
| 45 | Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells | Carcinogenesis | 2006 | 156 |
| 46 | THE ROLE OF METABOLISM AND SPECIFIC METABOLITES IN BENZENE-INDUCED TOXICITY: EVIDENCE AND ISSUES | Journal of Toxicology and Environmental Health - Part A: Current Issues | 2000 | 155 |
| 47 | Silibinin inhibits constitutive and TNFα-induced activation of NF-κB and sensitizes human prostate carcinoma DU145 cells to TNFα-induced apoptosis | Oncogene | 2002 | 154 |
| 48 | Cryopreservation of Stem Cells Using Trehalose: Evaluation of the Method Using a Human Hematopoietic Cell Line | Stem Cells and Development | 2004 | 152 |
| 49 | The risk of adverse drug events and hospital-related morbidity and mortality among older adults with potentially inappropriate medication use | American Journal of Geriatric Pharmacotherapy | 2006 | 151 |
| 50 | Potentiation of Warfarin by Dong Quai | Pharmacotherapy | 1999 | 149 |
