| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Predictors of COVID‐19 severity: A literature review | Reviews in Medical Virology | 2021 | 593 |
| 3 | Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2018 | 474 |
| 4 | Normotensive Ischemic Acute Renal Failure | New England Journal of Medicine | 2007 | 460 |
| 5 | A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors | Clinical Cancer Research | 1999 | 394 |
| 6 | Randomized Trial of a Slow-Release Versus a Standard Formulation of Cytarabine for the Intrathecal Treatment of Lymphomatous Meningitis | Journal of Clinical Oncology | 1999 | 393 |
| 7 | Cerebrospinal fluid cytology in patients with cancer | Journal of Clinical Oncology | 1998 | 383 |
| 8 | The Enterococcus: a Model of Adaptability to Its Environment | Clinical Microbiology Reviews | 2019 | 357 |
| 9 | Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2020 | 324 |
| 10 | Distribution of GPR30, a Seven Membrane–Spanning Estrogen Receptor, in Primary Breast Cancer and its Association with Clinicopathologic Determinants of Tumor Progression | Clinical Cancer Research | 2006 | 314 |
| 11 | High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary? | Journal of Clinical Oncology | 1998 | 304 |
| 12 | Minireview: G Protein-Coupled Estrogen Receptor-1, GPER-1: Its Mechanism of Action and Role in Female Reproductive Cancer, Renal and Vascular Physiology | Endocrinology | 2012 | 283 |
| 13 | Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring | 2017 | 283 |
| 14 | Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging | International Journal of Molecular Medicine | 2014 | 277 |
| 15 | Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis | Neuron | 2003 | 264 |
| 16 | An Approach to Studying Circadian Rhythms of Adolescent Humans | Journal of Biological Rhythms | 1997 | 237 |
| 17 | Get With the Guidelines for Cardiovascular Secondary Prevention | Archives of Internal Medicine | 2004 | 237 |
| 18 | Pathologic Evaluation of the Human Suprachiasmatic Nucleus in Severe Dementia | Journal of Neuropathology and Experimental Neurology | 1999 | 224 |
| 19 | A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy | Kidney International | 2010 | 219 |
| 20 | Postincarceration Fatal Overdoses After Implementing Medications for Addiction Treatment in a Statewide Correctional System | JAMA Psychiatry | 2018 | 215 |
| 21 | AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs | Journal of the American Society of Nephrology: JASN | 2015 | 212 |
| 22 | Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial | Lancet, The | 2014 | 210 |
| 23 | Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharides | Glycoconjugate Journal | 2001 | 209 |
| 24 | Mitochondrial DNA Damage as a Mechanism of Cell Loss in Alzheimer's Disease | Laboratory Investigation | 2000 | 205 |
| 25 | Diagnosis, management, and survival of patients with leptomeningeal cancer based on cerebrospinal fluid-flow status | Cancer | 1995 | 200 |
| 26 | Reconciliation of Recent Helicobacter pylori Treatment Guidelines in a Time of Increasing Resistance to Antibiotics | Gastroenterology | 2019 | 195 |
| 27 | Strategies for Optimizing Adherence to Highly Active Antiretroviral Therapy: Lessons from Research and Clinical Practice | Clinical Infectious Diseases | 2001 | 191 |
| 28 | Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy | American Journal of Physiology - Renal Physiology | 2009 | 188 |
| 29 | The genetics of hyperuricaemia and gout | Nature Reviews Rheumatology | 2012 | 188 |
| 30 | Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription | Experimental Hematology | 2010 | 186 |
| 31 | Complications of therapeutic plasma exchange: A prospective study of 1,727 procedures | Journal of Clinical Apheresis | 2007 | 181 |
| 32 | AN EPIDEMIOLOGIC STUDY OF THE RISKS ASSOCIATED WITH PERIPHERAL INTRAVENOUS CATHETERS | American Journal of Epidemiology | 1983 | 178 |
| 33 | Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies | Blood | 2012 | 177 |
| 34 | Acetylation-Dependent Signal Transduction for Type I Interferon Receptor | Cell | 2007 | 175 |
| 35 | Antimicrobial central venous catheters in adults: a systematic review and meta-analysis | Lancet Infectious Diseases, The | 2008 | 166 |
| 36 | Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming | Stem Cell Research and Therapy | 2015 | 164 |
| 37 | Hypertension Canada’s 2018 Guidelines for the Management of Hypertension in Pregnancy | Canadian Journal of Cardiology | 2018 | 164 |
| 38 | Understanding delay to medical care for HIV infection: the long-term non-presenter | Aids | 2001 | 163 |
| 39 | 5-fluorouracil induced cardiotoxicity: Review of the literature | Cardiology Journal | 2012 | 162 |
| 40 | Sleep in Women Across the Life Span | Chest | 2018 | 162 |
| 41 | Listeria monocytogenes:Clinical and Experimental Update | Journal of Infectious Diseases | 2002 | 160 |
| 42 | Preemptive Plasmapheresis and Recurrence of FSGS in High-Risk Renal Transplant Recipients | American Journal of Transplantation | 2005 | 158 |
| 43 | Pulmonary Aspergillosis and Invasive Disease in AIDS | Chest | 1998 | 153 |
| 44 | Percutaneous Image-guided Thermal Ablation and Radiation Therapy: Outcomes of Combined Treatment for 41 Patients with Inoperable Stage I/II Non–Small-Cell Lung Cancer | Journal of Vascular and Interventional Radiology | 2006 | 152 |
| 45 | Histone Deacetylase: A Potential Therapeutic Target for Fibrotic Disorders | Journal of Pharmacology and Experimental Therapeutics | 2010 | 152 |
| 46 | Hepatitis C disease among injection drug users: knowledge, perceived risk and willingness to receive treatment | Drug and Alcohol Dependence | 2001 | 151 |
| 47 | Healthy HIV-1-Infected Individuals on Highly Active Antiretroviral Therapy Harbor HIV-1 in Their Alveolar Macrophages | AIDS Research and Human Retroviruses | 2015 | 151 |
| 48 | Percutaneous Transluminal Coronary Angioplasty Versus Medical Therapy for Stable Angina Pectoris | Journal of the American College of Cardiology | 1997 | 150 |
| 49 | Barriers to Medications for Addiction Treatment: How Stigma Kills | Substance Use and Misuse | 2018 | 148 |
| 50 | Infectious Diseases Society of America Guidelines on the Diagnosis of Coronavirus Disease 2019 (COVID-19): Serologic Testing | Clinical Infectious Diseases | 2020 | 148 |
