| # | Title | Journal | Year | Citations |
|---|
| 1 | CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer | Nature Genetics | 2006 | 1,715 |
| 2 | Predictive and Prognostic Impact of Epidermal Growth Factor Receptor Mutation in Non–Small-Cell Lung Cancer Patients Treated With Gefitinib | Journal of Clinical Oncology | 2005 | 736 |
| 3 | Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial | Lancet Oncology, The | 2014 | 713 |
| 4 | Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance | Modern Pathology | 2012 | 262 |
| 5 | Core-Needle Biopsy Is More Useful Than Repeat Fine-Needle Aspiration in Thyroid Nodules Read as Nondiagnostic or Atypia of Undetermined Significance by the Bethesda System for Reporting Thyroid Cytopathology | Thyroid | 2012 | 218 |
| 6 | Mechanisms of Acquired Resistance to AZD9291 | Journal of Thoracic Oncology | 2015 | 202 |
| 7 | Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers | Lung Cancer | 2015 | 187 |
| 8 | Vandetanib in pretreated patients with advanced non-small cell lung cancer-harboring RET rearrangement: a phase II clinical trial | Annals of Oncology | 2017 | 181 |
| 9 | An increase in cancer stem cell population after primary systemic therapy is a poor prognostic factor in breast cancer | British Journal of Cancer | 2011 | 172 |
| 10 | MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcome | British Journal of Cancer | 2012 | 163 |
| 11 | Comparison of Shear-Wave and Strain Ultrasound Elastography in the Differentiation of Benign and Malignant Breast Lesions | American Journal of Roentgenology | 2013 | 154 |
| 12 | KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease | Clinical and Molecular Hepatology | 2021 | 152 |
| 13 | Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas | European Journal of Cancer | 2015 | 150 |
| 14 | Heterogeneity of Genetic Changes Associated with Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancer | Journal of Thoracic Oncology | 2013 | 147 |
| 15 | Clinicopathologic Analysis of PD-L1 and PD-L2 Expression in Renal Cell Carcinoma: Association with Oncogenic Proteins Status | Annals of Surgical Oncology | 2016 | 145 |
| 16 | Stiffness of tumours measured by shear-wave elastography correlated with subtypes of breast cancer | European Radiology | 2013 | 143 |
| 17 | Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status | Modern Pathology | 2015 | 143 |
| 18 | Clinical significance of intratumoral HER2 heterogeneity in gastric cancer | European Journal of Cancer | 2013 | 139 |
| 19 | Clinicopathological analysis of programmed cell death 1 and programmed cell death ligand 1 expression in the tumour microenvironments of diffuse large B cell lymphomas | Histopathology | 2016 | 135 |
| 20 | PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung | Human Pathology | 2016 | 135 |
| 21 | Urban particulate matter in air pollution penetrates into the barrier-disrupted skin and produces ROS-dependent cutaneous inflammatory response in vivo | Journal of Dermatological Science | 2018 | 135 |
| 22 | Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer | Journal of Clinical Investigation | 2018 | 133 |
| 23 | Tumor Suppressor miRNA-204-5p Regulates Growth, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer | Cancer Research | 2019 | 126 |
| 24 | Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation | Cell Metabolism | 2016 | 125 |
| 25 | Abatacept alleviates severe autoimmune symptoms in a patient carrying a de novo variant in CTLA-4 | Journal of Allergy and Clinical Immunology | 2016 | 125 |
| 26 | EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3 | OncoImmunology | 2016 | 124 |
| 27 | Radical excision of pediatric craniopharyngioma: recurrence pattern and prognostic factors | Child's Nervous System | 2001 | 119 |
| 28 | Preoperative Sonographic Classification of Axillary Lymph Nodes in Patients With Breast Cancer: Node-to-Node Correlation With Surgical Histology and Sentinel Node Biopsy Results | American Journal of Roentgenology | 2009 | 115 |
| 29 | Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients | Lung Cancer | 2012 | 115 |
| 30 | Primary resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with non-small-cell lung cancer harboring TKI-sensitive EGFR mutations: an exploratory study | Annals of Oncology | 2013 | 111 |
| 31 | HER2 Heterogeneity Affects Trastuzumab Responses and Survival in Patients With HER2-Positive Metastatic Breast Cancer | American Journal of Clinical Pathology | 2014 | 109 |
| 32 | The clinicopathologic characteristics and prognostic significance of triple-negativity in node-negative breast cancer | BMC Cancer | 2008 | 108 |
| 33 | Change in PD-L1 Expression After Acquiring Resistance to Gefitinib in EGFR-Mutant Non–Small-Cell Lung Cancer | Clinical Lung Cancer | 2016 | 107 |
| 34 | Assessment of hepatic steatosis by using attenuation imaging: a quantitative, easy-to-perform ultrasound technique | European Radiology | 2019 | 104 |
| 35 | RNA editing in RHOQ promotes invasion potential in colorectal cancer | Journal of Experimental Medicine | 2014 | 97 |
| 36 | An increase of M2 macrophages predicts poor prognosis in patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone | Leukemia and Lymphoma | 2014 | 94 |
| 37 | MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma | Oncotarget | 2015 | 94 |
| 38 | MR elastography for noninvasive assessment of hepatic fibrosis: Reproducibility of the examination and reproducibility and repeatability of the liver stiffness value measurement | Journal of Magnetic Resonance Imaging | 2014 | 93 |
| 39 | Rare and complex mutations of epidermal growth factor receptor, and efficacy of tyrosine kinase inhibitor in patients with non-small cell lung cancer | International Journal of Clinical Oncology | 2014 | 92 |
| 40 | MR imaging of myxofibrosarcoma and undifferentiated sarcoma with emphasis on tail sign; diagnostic and prognostic value | European Radiology | 2014 | 92 |
| 41 | Comparison of diffusion-weighted MR imaging and FDG PET/CT to predict pathological complete response to neoadjuvant chemotherapy in patients with breast cancer | European Radiology | 2012 | 91 |
| 42 | Progression of Pancreatic Branch Duct Intraductal Papillary Mucinous Neoplasm Associates With Cyst Size | Gastroenterology | 2018 | 91 |
| 43 | High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected non-small cell lung cancer | British Journal of Cancer | 2008 | 90 |
| 44 | A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders | Blood | 2014 | 90 |
| 45 | Histopathological evaluation of liver fibrosis and cirrhosis regression | Clinical and Molecular Hepatology | 2017 | 90 |
| 46 | Mucoepidermoid carcinoma of lung: Potential target of EGFR-directed treatment | Lung Cancer | 2008 | 89 |
| 47 | Combined hepatocellular cholangiocarcinoma: LI-RADS v2017 categorisation for differential diagnosis and prognostication on gadoxetic acid-enhanced MR imaging | European Radiology | 2019 | 89 |
| 48 | Characterisation of PD-L1-positive subsets of microsatellite-unstable colorectal cancers | British Journal of Cancer | 2016 | 88 |
| 49 | Visceral Obesity Predicts Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Disease | Medicine (United States) | 2015 | 85 |
| 50 | A statement by the Japan‐Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage | Journal of Hepato-Biliary-Pancreatic Sciences | 2018 | 85 |
