| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet, The | 2012 | 1,752 |
| 3 | Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 1,749 |
| 4 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 5 | COVID-19: towards controlling of a pandemic | Lancet, The | 2020 | 1,193 |
| 6 | Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials | Lancet, The | 2017 | 840 |
| 7 | Predictive and Prognostic Impact of Epidermal Growth Factor Receptor Mutation in Non–Small-Cell Lung Cancer Patients Treated With Gefitinib | Journal of Clinical Oncology | 2005 | 736 |
| 8 | Transcutaneous ultrasound energy harvesting using capacitive triboelectric technology | Science | 2019 | 569 |
| 9 | Six-Month Versus 12-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents | Circulation | 2012 | 555 |
| 10 | Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity | Clinical Cancer Research | 2016 | 554 |
| 11 | Prognostic Value of Fractional Flow Reserve | Journal of the American College of Cardiology | 2014 | 513 |
| 12 | Oncological Benefits of Neoadjuvant Chemoradiation With Gemcitabine Versus Upfront Surgery in Patients With Borderline Resectable Pancreatic Cancer | Annals of Surgery | 2018 | 497 |
| 13 | 2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation | Europace | 2021 | 494 |
| 14 | Impact of Intracoronary Cell Therapy on Left Ventricular Function in the Setting of Acute Myocardial Infarction | Journal of the American College of Cardiology | 2007 | 484 |
| 15 | Afatinib versus gefitinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer: overall survival data from the phase IIb LUX-Lung 7 trial | Annals of Oncology | 2017 | 425 |
| 16 | Activity of Crizotinib (PF02341066), a Dual Mesenchymal-Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) Inhibitor, in a Non-small Cell Lung Cancer Patient with De Novo MET Amplification | Journal of Thoracic Oncology | 2011 | 407 |
| 17 | Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials | BMJ, The | 2013 | 374 |
| 18 | Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study | Lancet Oncology, The | 2020 | 371 |
| 19 | A phase III randomized study of 5-fluorouracil and cisplatin versus 5-fluorouracil, doxorubicin, and mitomycin C versus 5-fluorouracil alone in the treatment of advanced gastric cancer | Cancer | 1993 | 354 |
| 20 | Dabrafenib in patients with BRAFV600E-positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, phase 2 trial | Lancet Oncology, The | 2016 | 352 |
| 21 | Mortality in patients treated with extended duration dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and Bayesian network meta-analysis of randomised trials | Lancet, The | 2015 | 345 |
| 22 | Oxaliplatin, fluorouracil, and leucovorin versus fluorouracil and leucovorin as adjuvant chemotherapy for locally advanced rectal cancer after preoperative chemoradiotherapy (ADORE): an open-label, multicentre, phase 2, randomised controlled trial | Lancet Oncology, The | 2014 | 336 |
| 23 | Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI | Journal of the American College of Cardiology | 2016 | 319 |
| 24 | Validation of the Korean version of the EORTC QLQ-C30 | Quality of Life Research | 2004 | 311 |
| 25 | Physiologic Assessment of Jailed Side Branch Lesions Using Fractional Flow Reserve | Journal of the American College of Cardiology | 2005 | 297 |
| 26 | Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer | Annals of Oncology | 2007 | 285 |
| 27 | Global Longitudinal Strain to Predict Mortality in Patients With Acute Heart Failure | Journal of the American College of Cardiology | 2018 | 284 |
| 28 | Identification of type 2 diabetes loci in 433,540 East Asian individuals | Nature | 2020 | 282 |
| 29 | A randomized phase II study of the MEK1/MEK2 inhibitor trametinib (GSK1120212) compared with docetaxel in KRAS-mutant advanced non-small-cell lung cancer (NSCLC) | Annals of Oncology | 2015 | 275 |
| 30 | Transarterial Chemoembolization Can Be Safely Performed in Patients with Hepatocellular Carcinoma Invading the Main Portal Vein and May Improve the Overall Survival | Radiology | 2011 | 264 |
| 31 | Renal Toxicity Evaluation and Comparison Between Visipaque (Iodixanol) and Hexabrix (Ioxaglate) in Patients With Renal Insufficiency Undergoing Coronary Angiography | Journal of the American College of Cardiology | 2006 | 262 |
| 32 | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | Nature Genetics | 2022 | 250 |
| 33 | Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls | Nature | 2019 | 248 |
| 34 | EUS-Guided Biliary Drainage Versus ERCP for the Primary Palliation of Malignant Biliary Obstruction: A Multicenter Randomized Clinical Trial | American Journal of Gastroenterology | 2018 | 244 |
| 35 | Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study | Annals of Oncology | 2018 | 243 |
| 36 | The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP | Journal of Biological Chemistry | 2004 | 240 |
| 37 | Durvalumab with or without tremelimumab in patients with recurrent or metastatic head and neck squamous cell carcinoma: EAGLE, a randomized, open-label phase III study | Annals of Oncology | 2020 | 240 |
| 38 | Non-alcoholic fatty liver disease across the spectrum of hypothyroidism | Journal of Hepatology | 2012 | 234 |
| 39 | Physiological evaluation of the provisional side-branch intervention strategy for bifurcation lesions using fractional flow reserve | European Heart Journal | 2008 | 220 |
| 40 | Dual Antiplatelet Therapy Duration Based on Ischemic and Bleeding Risks After Coronary Stenting | Journal of the American College of Cardiology | 2019 | 218 |
| 41 | Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation | Blood | 2010 | 217 |
| 42 | Pan-Cancer Immunogenomic Perspective on the Tumor Microenvironment Based on PD-L1 and CD8 T-Cell Infiltration | Clinical Cancer Research | 2016 | 217 |
| 43 | Evolving antithrombotic treatment patterns for patients with newly diagnosed atrial fibrillation | Heart | 2017 | 205 |
| 44 | Interstitial lung disease in patients with polymyositis, dermatomyositis and amyopathic dermatomyositis | Rheumatology | 2005 | 202 |
| 45 | Bronchoscopic Assessment of the Evolution of Endobronchial Tuberculosis | Chest | 2000 | 196 |
| 46 | Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study | Lancet Diabetes and Endocrinology,the | 2021 | 192 |
| 47 | 2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary | Thrombosis and Haemostasis | 2022 | 192 |
| 48 | Skeletal Muscle Depletion Predicts the Prognosis of Patients with Advanced Pancreatic Cancer Undergoing Palliative Chemotherapy, Independent of Body Mass Index | PLoS ONE | 2015 | 183 |
| 49 | Vandetanib in pretreated patients with advanced non-small cell lung cancer-harboring RET rearrangement: a phase II clinical trial | Annals of Oncology | 2017 | 181 |
| 50 | Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial | Lancet, The | 2021 | 177 |
