| # | Title | Journal | Year | Citations |
|---|
| 1 | IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy | Nature Genetics | 2009 | 1,808 |
| 2 | Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure | Hepatology | 2016 | 550 |
| 3 | Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepatitis C virus coinfection | Lancet, The | 2003 | 511 |
| 4 | Acute portal vein thrombosis unrelated to cirrhosis: A prospective multicenter follow-up study | Hepatology | 2010 | 458 |
| 5 | A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis | Nature Genetics | 2015 | 435 |
| 6 | Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients | Genome Medicine | 2017 | 420 |
| 7 | Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis | Gastroenterology | 2017 | 355 |
| 8 | Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase | Hepatology | 2007 | 276 |
| 9 | Itraconazole Prevents Invasive Fungal Infections in Neutropenic Patients Treated for Hematologic Malignancies: Evidence From a Meta-Analysis of 3,597 Patients | Journal of Clinical Oncology | 2003 | 263 |
| 10 | Good long-term outcome of Budd-Chiari syndrome with a step-wise management | Hepatology | 2013 | 237 |
| 11 | Comparison of Capsule Endoscopy and Magnetic Resonance Imaging for the Detection of Polyps of the Small Intestine in Patients with Familial Adenomatous Polyposis or with Peutz-Jeghers’ Syndrome | Endoscopy | 2004 | 229 |
| 12 | Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats | Hepatology | 2014 | 224 |
| 13 | Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF | Journal of Hepatology | 2020 | 223 |
| 14 | A systematic review of phase-II trials of thalidomide monotherapy in patients with relapsed or refractory multiple myeloma | British Journal of Haematology | 2006 | 218 |
| 15 | Functional Variants of the Central Bile Acid Sensor FXR Identified in Intrahepatic Cholestasis of Pregnancy | Gastroenterology | 2007 | 215 |
| 16 | Neutropenic enterocolitis in adults: systematic analysis of evidence quality | European Journal of Haematology | 2005 | 214 |
| 17 | Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells | Journal of Hepatology | 2010 | 197 |
| 18 | Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis | Hepatology | 2004 | 196 |
| 19 | Prevention of Rebleeding From Esophageal Varices in Patients With Cirrhosis Receiving Small-Diameter Stents Versus Hemodynamically Controlled Medical Therapy | Gastroenterology | 2015 | 196 |
| 20 | Association between thePNPLA3(rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data | Hepatology | 2014 | 193 |
| 21 | Bleeding Complications after Percutaneous Liver Biopsy | Digestion | 2003 | 187 |
| 22 | Transient and 2-Dimensional Shear-Wave Elastography Provide Comparable Assessment of Alcoholic Liver Fibrosis and Cirrhosis | Gastroenterology | 2016 | 186 |
| 23 | MDRD Equations for Estimation of GFR in Renal Transplant Recipients | American Journal of Transplantation | 2005 | 170 |
| 24 | FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis | Scientific Reports | 2016 | 168 |
| 25 | Phase III study of all-trans retinoic acid in previously untreated patients 61 years or older with acute myeloid leukemia | Leukemia | 2004 | 163 |
| 26 | Association Between Portosystemic Shunts and Increased Complications and Mortality in Patients With Cirrhosis | Gastroenterology | 2018 | 162 |
| 27 | Comparison of Meld, Child-Pugh, and Emory Model for The Prediction of Survival in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunting | American Journal of Gastroenterology | 2003 | 156 |
| 28 | The FXR Agonist Obeticholic Acid Prevents Gut Barrier Dysfunction and Bacterial Translocation in Cholestatic Rats | American Journal of Pathology | 2015 | 156 |
| 29 | Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease | Nature Communications | 2015 | 156 |
| 30 | Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis | Journal of Hepatology | 2013 | 154 |
| 31 | The HLA-A2 Restricted T Cell Epitope HCV Core35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells | American Journal of Pathology | 2005 | 149 |
| 32 | Porto-sinusoidal vascular disease: proposal and description of a novel entity | The Lancet Gastroenterology and Hepatology | 2019 | 149 |
| 33 | Clostridium difficileInfection in Patients with Neutropenia | Clinical Infectious Diseases | 2001 | 147 |
| 34 | Preemptive‐TIPS Improves Outcome in High‐Risk Variceal Bleeding: An Observational Study | Hepatology | 2019 | 144 |
| 35 | Pharmacokinetics and pharmacodynamic action of budesonide in early- and late-stage primary biliary cirrhosis | Hepatology | 2003 | 143 |
| 36 | Allogeneic Dendritic Cells Fused with Tumor Cells: Preclinical Results and Outcome of a Clinical Phase I/II Trial in Patients with Metastatic Renal Cell Carcinoma | Human Gene Therapy | 2003 | 141 |
| 37 | HIV-1 Infection Leads to Increased HLA-E Expression Resulting in Impaired Function of Natural Killer Cells | Antiviral Therapy | 2005 | 140 |
| 38 | Mechanisms of Disease: the genetic epidemiology of gallbladder stones | Nature Reviews Gastroenterology & Hepatology | 2005 | 138 |
| 39 | Hemodynamic effects of the angiotensin II receptor antagonist irbesartan in patients with cirrhosis and portal hypertension | Gastroenterology | 2001 | 137 |
| 40 | Mechanisms of extrahepatic vasodilation in portal hypertension | Gut | 2008 | 134 |
| 41 | Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis | Frontiers in Immunology | 2019 | 134 |
| 42 | NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner | Laboratory Investigation | 2012 | 132 |
| 43 | Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals | Gastroenterology | 2018 | 132 |
| 44 | Dependence of Oxalate Absorption on the Daily Calcium Intake | Journal of the American Society of Nephrology: JASN | 2004 | 129 |
| 45 | Hepatocyte Growth Factor (HGF) Inhibits Collagen I and IV Synthesis in Hepatic Stellate Cells by miRNA-29 Induction | PLoS ONE | 2011 | 129 |
| 46 | Interferon-lambda serum levels in hepatitis C | Journal of Hepatology | 2011 | 128 |
| 47 | Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis | Scientific Reports | 2015 | 127 |
| 48 | Calculation of glomerular filtration rate based on Cystatin C in cirrhotic patients | Nephrology Dialysis Transplantation | 2006 | 125 |
| 49 | Natural killer p46Highexpression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis | Hepatology | 2012 | 122 |
| 50 | Transduction of Human PBMC-Derived Dendritic Cells and Macrophages by an HIV-1-Based Lentiviral Vector System | Molecular Therapy | 2000 | 120 |
