| # | Title | Journal | Year | Citations |
|---|
| 1 | The JAK-STAT Pathway at Twenty | Immunity | 2012 | 1,221 |
| 2 | Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF B | Genes and Development | 2007 | 532 |
| 3 | Complex Modulation of Cell Type-Specific Signaling in Response to Type I Interferons | Immunity | 2006 | 480 |
| 4 | The circadian clock and pathology of the ageing brain | Nature Reviews Neuroscience | 2012 | 406 |
| 5 | Rates of in situ transcription and splicing in large human genes | Nature Structural and Molecular Biology | 2009 | 386 |
| 6 | Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis | Blood | 2012 | 343 |
| 7 | Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms | Cancer Cell | 2015 | 341 |
| 8 | Interferons and viral infections | BioFactors | 2009 | 334 |
| 9 | Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation | Nature Chemical Biology | 2006 | 320 |
| 10 | Roles of unphosphorylated STATs in signaling | Cell Research | 2008 | 313 |
| 11 | Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA | Virology | 2006 | 287 |
| 12 | Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 272 |
| 13 | IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage | EMBO Journal | 2013 | 269 |
| 14 | Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65 | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 265 |
| 15 | Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis | Journal of Virology | 2015 | 260 |
| 16 | Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 259 |
| 17 | Small molecules that reactivate p53 in renal cell carcinoma reveal a NF- B-dependent mechanism of p53 suppression in tumors | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 257 |
| 18 | Nucleosomes Can Form a Polar Barrier to Transcript Elongation by RNA Polymerase II | Molecular Cell | 2006 | 248 |
| 19 | A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis | Virology | 2007 | 244 |
| 20 | TheISG56/IFIT1Gene Family | Journal of Interferon and Cytokine Research | 2011 | 244 |
| 21 | Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3 | Cancer Cell | 2011 | 233 |
| 22 | p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 229 |
| 23 | A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity | Journal of Experimental Medicine | 2007 | 227 |
| 24 | Viral apoptosis is induced by IRF-3-mediated activation of Bax | EMBO Journal | 2010 | 224 |
| 25 | Mutations in U4atac snRNA, a Component of the Minor Spliceosome, in the Developmental Disorder MOPD I | Science | 2011 | 223 |
| 26 | STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 222 |
| 27 | PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 205 |
| 28 | Curaxins: Anticancer Compounds That Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT | Science Translational Medicine | 2011 | 199 |
| 29 | Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST) | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 194 |
| 30 | Unconventional Mechanism of mRNA Capping by the RNA-Dependent RNA Polymerase of Vesicular Stomatitis Virus | Molecular Cell | 2007 | 190 |
| 31 | Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells | Blood | 2007 | 185 |
| 32 | Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3 | Cancer Research | 2006 | 180 |
| 33 | BMAL1-dependent regulation of the mTOR signaling pathway delays aging | Aging | 2014 | 179 |
| 34 | SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes | Blood | 2012 | 173 |
| 35 | New connections between splicing and human disease | Trends in Genetics | 2012 | 160 |
| 36 | How cells respond to interferons revisited: From early history to current complexity | Cytokine and Growth Factor Reviews | 2007 | 159 |
| 37 | Human Cytomegalovirus Infection Alters the Expression of Cellular MicroRNA Species That Affect Its Replication | Journal of Virology | 2008 | 159 |
| 38 | Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms | Blood | 2013 | 156 |
| 39 | Interferon-Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis | PLoS Pathogens | 2012 | 156 |
| 40 | Distinct Induction Patterns and Functions of Two Closely Related Interferon-inducible Human Genes, ISG54 and ISG56 | Journal of Biological Chemistry | 2006 | 148 |
| 41 | Proinflammatory Stimuli Induce IKKα-Mediated Phosphorylation of PIAS1 to Restrict Inflammation and Immunity | Cell | 2007 | 145 |
| 42 | Phosphoprotein of Human Parainfluenza Virus Type 3 Blocks Autophagosome-Lysosome Fusion to Increase Virus Production | Cell Host and Microbe | 2014 | 142 |
| 43 | Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1 | EMBO Journal | 2008 | 133 |
| 44 | Coordinated Regulation and Widespread Cellular Expression of Interferon-Stimulated Genes (ISG) ISG-49, ISG-54, and ISG-56 in the Central Nervous System after Infection with Distinct Viruses | Journal of Virology | 2007 | 130 |
| 45 | Prospective therapeutic applications of p53 inhibitors | Biochemical and Biophysical Research Communications | 2005 | 129 |
| 46 | Circadian clock protein BMAL1 regulates cellular senescence in vivo | Cell Cycle | 2011 | 127 |
| 47 | No Love Lost Between Viruses and Interferons | Annual Review of Virology | 2015 | 123 |
| 48 | Mechanism of transcription through a nucleosome by RNA polymerase II | Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms | 2013 | 121 |
| 49 | A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation | Genes and Development | 2006 | 120 |
| 50 | The Role of the Transcription Bubble and TFIIB in Promoter Clearance by RNA Polymerase II | Molecular Cell | 2005 | 118 |
