| # | Title | Journal | Year | Citations |
|---|
| 1 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 2 | Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies | Epilepsia | 2010 | 3,400 |
| 3 | IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 | Diabetes Research and Clinical Practice | 2022 | 2,873 |
| 4 | A variant in CDKAL1 influences insulin response and risk of type 2 diabetes | Nature Genetics | 2007 | 966 |
| 5 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 959 |
| 6 | Variants conferring risk of atrial fibrillation on chromosome 4q25 | Nature | 2007 | 853 |
| 7 | Use of convalescent plasma therapy in SARS patients in Hong Kong | European Journal of Clinical Microbiology and Infectious Diseases | 2005 | 838 |
| 8 | Peritoneal Dialysis-Related Infections Recommendations: 2010 Update | Peritoneal Dialysis International | 2010 | 770 |
| 9 | ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment | Peritoneal Dialysis International | 2016 | 745 |
| 10 | Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction | Nature Genetics | 2009 | 709 |
| 11 | Practical recommendations for the management of diabetes in patients with COVID-19 | Lancet Diabetes and Endocrinology,the | 2020 | 680 |
| 12 | Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes | Nature Genetics | 2007 | 670 |
| 13 | Intrathoracic Impedance Monitoring in Patients With Heart Failure | Circulation | 2005 | 639 |
| 14 | Left Ventricular Reverse Remodeling but Not Clinical Improvement Predicts Long-Term Survival After Cardiac Resynchronization Therapy | Circulation | 2005 | 631 |
| 15 | Prevalence and Clinical Correlates of YMDD Variants during Lamivudine Therapy for Patients with Chronic Hepatitis B | Clinical Infectious Diseases | 2003 | 604 |
| 16 | Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS | Diabetic Medicine | 2006 | 604 |
| 17 | Predictors of left ventricular reverse remodeling after cardiac resynchronization therapy for heart failure secondary to idiopathic dilated or ischemic cardiomyopathy | American Journal of Cardiology | 2003 | 580 |
| 18 | Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 579 |
| 19 | Tissue Doppler Imaging Is Superior to Strain Rate Imaging and Postsystolic Shortening on the Prediction of Reverse Remodeling in Both Ischemic and Nonischemic Heart Failure After Cardiac Resynchronization Therapy | Circulation | 2004 | 577 |
| 20 | Peptic ulcer disease | Lancet, The | 2017 | 570 |
| 21 | Clopidogrel versus Aspirin and Esomeprazole to Prevent Recurrent Ulcer Bleeding | New England Journal of Medicine | 2005 | 567 |
| 22 | Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapy | Hepatology | 2001 | 565 |
| 23 | Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians | Nature Genetics | 2012 | 545 |
| 24 | Understanding Nonresponders of Cardiac Resynchronization Therapy-Current and Future Perspectives | Journal of Cardiovascular Electrophysiology | 2005 | 541 |
| 25 | Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years | Gut | 2010 | 538 |
| 26 | Celecoxib versus Diclofenac and Omeprazole in Reducing the Risk of Recurrent Ulcer Bleeding in Patients with Arthritis | New England Journal of Medicine | 2002 | 532 |
| 27 | Association between HLA-B*1502 Allele and Antiepileptic Drug-Induced Cutaneous Reactions in Han Chinese | Epilepsia | 2007 | 521 |
| 28 | Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients | Journal of Clinical Virology | 2004 | 516 |
| 29 | TGF-β/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29 | Journal of the American Society of Nephrology: JASN | 2011 | 511 |
| 30 | Tissue Doppler Imaging | Journal of the American College of Cardiology | 2007 | 508 |
| 31 | Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection | Gastroenterology | 2003 | 506 |
| 32 | Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection1 1The authors thank Man-yee Yung, Sara Fung, Dr. Bonnie Kwan, and Dr. Thomas Li for their help in retrieving patient information. | Gastroenterology | 2003 | 490 |
| 33 | Geographical variability and environmental risk factors in inflammatory bowel disease | Gut | 2013 | 476 |
| 34 | Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza | Journal of Infectious Diseases | 2009 | 461 |
| 35 | Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity | Clinical Immunology | 2008 | 457 |
| 36 | HRS Expert Consensus Statement on remote interrogation and monitoring for cardiovascular implantable electronic devices | Heart Rhythm | 2015 | 449 |
| 37 | Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus | Lupus | 2000 | 438 |
| 38 | A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke | Nature Genetics | 2009 | 434 |
| 39 | Effects of Diet and Exercise on Obesity-Related Vascular Dysfunction in Children | Circulation | 2004 | 394 |
| 40 | Biventricular Pacing in Patients with Bradycardia and Normal Ejection Fraction | New England Journal of Medicine | 2009 | 392 |
| 41 | Circulating Endotoxemia | Clinical Journal of the American Society of Nephrology: CJASN | 2011 | 388 |
| 42 | Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 363 |
| 43 | A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging | Journal of the American College of Cardiology | 2005 | 361 |
| 44 | Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma | Nature Genetics | 2010 | 357 |
| 45 | Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication | Gut | 2004 | 339 |
| 46 | The epidemiology of inflammatory bowel disease: East meets west | Journal of Gastroenterology and Hepatology (Australia) | 2020 | 334 |
| 47 | Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians | Diabetes | 2008 | 331 |
| 48 | The natural history of epilepsy: an epidemiological view | Journal of Neurology, Neurosurgery and Psychiatry | 2004 | 325 |
| 49 | A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease | Gut | 2014 | 317 |
| 50 | Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation | International Journal of Cardiology | 2014 | 316 |
