| # | Title | Journal | Year | Citations |
|---|
| 1 | Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study | European Journal of Medicinal Chemistry | 2010 | 207 |
| 2 | Pyrido [2, 3-d]pyrimidines and Pyrimido[5′, 4′:5, 6]pyrido[2, 3-d]pyrimidines as New Antiviral Agents: Synthesis and Biological Activity | Archiv Der Pharmazie | 2002 | 197 |
| 3 | Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study | Bioorganic and Medicinal Chemistry | 2011 | 140 |
| 4 | Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2 | Bioorganic and Medicinal Chemistry | 2012 | 133 |
| 5 | Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2-a]pyrimidines | European Journal of Medicinal Chemistry | 2011 | 132 |
| 6 | Synthesis, antimicrobial activity and conformational analysis of novel substituted pyridines: BF3-promoted reaction of hydrazine with 2-alkoxy pyridines | Bioorganic and Medicinal Chemistry | 2004 | 112 |
| 7 | Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: Anti-inflammatory and analgesic activities | European Journal of Medicinal Chemistry | 2015 | 97 |
| 8 | Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents | European Journal of Medicinal Chemistry | 2019 | 81 |
| 9 | Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties | European Journal of Medicinal Chemistry | 2014 | 78 |
| 10 | Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies | Bioorganic and Medicinal Chemistry | 2016 | 70 |
| 11 | Synthesis andin vitroanticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents | Journal of Enzyme Inhibition and Medicinal Chemistry | 2019 | 69 |
| 12 | Synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents | European Journal of Medicinal Chemistry | 2017 | 67 |
| 13 | Synthesis and in vitro antiproliferative activity of new 1,3,4-oxadiazole derivatives possessing sulfonamide moiety | European Journal of Medicinal Chemistry | 2015 | 66 |
| 14 | Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of fused [1,3,4]thiadiazoles | European Journal of Medicinal Chemistry | 2013 | 65 |
| 15 | Synthesis, antimicrobial activity and molecular modeling of cobalt and nickel complexes containing the bulky ligand: bis[N-(2,6-diisopropylphenyl)imino] acenaphthene | European Journal of Medicinal Chemistry | 2005 | 64 |
| 16 | Simultaneous determination of loratadine and desloratadine in pharmaceutical preparations using liquid chromatography with a microemulsion as eluent | Journal of Pharmaceutical and Biomedical Analysis | 2007 | 63 |
| 17 | Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives | Bioorganic and Medicinal Chemistry | 2016 | 63 |
| 18 | Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity | Journal of Enzyme Inhibition and Medicinal Chemistry | 2020 | 61 |
| 19 | Synthesis and in vitro antitumor evaluation of some new thiophenes and thieno[2,3-d]pyrimidine derivatives | Bioorganic Chemistry | 2018 | 59 |
| 20 | Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4(3H)quinazolinone analogues | Journal of Enzyme Inhibition and Medicinal Chemistry | 2016 | 58 |
| 21 | Synthesis, antimicrobial and antiviral evaluation of certain thienopyrimidine derivatives | European Journal of Medicinal Chemistry | 1995 | 57 |
| 22 | Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2 | Bioorganic and Medicinal Chemistry Letters | 2013 | 57 |
| 23 | Synthesis and in vitro antitumor activity of new series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives | European Journal of Medicinal Chemistry | 2014 | 56 |
| 24 | Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer | Bioorganic Chemistry | 2018 | 56 |
| 25 | Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions | Bioorganic Chemistry | 2019 | 56 |
| 26 | Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study | Journal of Enzyme Inhibition and Medicinal Chemistry | 2018 | 55 |
| 27 | Lewis acid-promoted transformation of 2-alkoxypyridines into 2-aminopyridines and their antibacterial activity. Part 2: Remarkably facile C–N bond formation | Bioorganic and Medicinal Chemistry | 2005 | 54 |
| 28 | Synthesis and antitumor evaluation of novel cyclic arylsulfonylureas: ADME-T and pharmacophore prediction | European Journal of Medicinal Chemistry | 2010 | 54 |
| 29 | SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX | Bioorganic Chemistry | 2019 | 53 |
| 30 | One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells | Journal of Enzyme Inhibition and Medicinal Chemistry | 2018 | 52 |
| 31 | Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction | Bioorganic Chemistry | 2019 | 52 |
| 32 | Investigating the structure–activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors | RSC Advances | 2021 | 52 |
| 33 | Synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs | European Journal of Medicinal Chemistry | 2017 | 51 |
| 34 | Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies | European Journal of Medicinal Chemistry | 2016 | 50 |
| 35 | Nonclassical antifolates, part 5. Benzodiazepine analogs as a new class of DHFR inhibitors: Synthesis, antitumor testing and molecular modeling study | European Journal of Medicinal Chemistry | 2014 | 49 |
| 36 | DFT and experimental (FT-IR and FT-Raman) investigation of vibrational spectroscopy and molecular docking studies of 2-(4-oxo-3-phenethyl-3,4-dihydroquinazolin-2-ylthio)-N-(3,4,5-trimethoxyphenyl) acetamide | Journal of Molecular Structure | 2016 | 49 |
| 37 | Crystal structure, Hirshfeld surface analysis and DFT studies of 5-(adamantan-1-yl)-3-[(4-chlorobenzyl)sulfanyl]-4-methyl-4H-1,2,4-triazole, a potential 11β-HSD1 inhibitor | Scientific Reports | 2019 | 47 |
| 38 | Differential-Pulse Polarographic Determination of Some N-Substituted Phenothiazine Derivatives in Dosage Forms and Urine Through Treatment with Nitrous Acid | Mikrochimica Acta | 2000 | 46 |
| 39 | Synthesis and anti-inflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: Molecular modeling study | European Journal of Medicinal Chemistry | 2010 | 46 |
| 40 | Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies | Journal of Enzyme Inhibition and Medicinal Chemistry | 2016 | 46 |
| 41 | Synthesis, DNA-binding, and Antiviral Activity of Certain Pyrazolo[3,4-d]pyrimidine Derivatives | Archiv Der Pharmazie | 2000 | 45 |
| 42 | Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents | Medicinal Chemistry Research | 2013 | 45 |
| 43 | 3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies | European Journal of Medicinal Chemistry | 2020 | 45 |
| 44 | Synthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies | Journal of Enzyme Inhibition and Medicinal Chemistry | 2016 | 44 |
| 45 | Isatin-β-thiocarbohydrazones: Microwave-assisted synthesis, antitumor activity and structure-activity relationship | European Journal of Medicinal Chemistry | 2017 | 43 |
| 46 | Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3 H )-one as DHFR inhibitors | Bioorganic Chemistry | 2017 | 43 |
| 47 | Piperidine nucleus in the field of drug discovery | Future Journal of Pharmaceutical Sciences | 2021 | 43 |
| 48 | Synthesis and biological evaluation of novel 6-nitro-5-substituted aminoquinolines as local anesthetic and anti-arrhythmic agents: molecular modeling study | Bioorganic and Medicinal Chemistry | 2005 | 42 |
| 49 | Design, synthesis, in vitro antiproliferative evaluation, and kinase inhibitory effects of a new series of imidazo[2,1-b]thiazole derivatives | European Journal of Medicinal Chemistry | 2015 | 42 |
| 50 | Tyrosine kinase inhibition effects of novel Pyrazolo[1,5-a]pyrimidines and Pyrido[2,3-d]pyrimidines ligand: Synthesis, biological screening and molecular modeling studies | Bioorganic Chemistry | 2018 | 41 |
