# | Title | Journal | Year | Citations |
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1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
2 | Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria | Science | 2005 | 1,576 |
3 | Myotonic Dystrophy Type 2 Caused by a CCTG Expansion in Intron 1 of ZNF9 | Science | 2001 | 1,172 |
4 | Melatonin as a natural ally against oxidative stress: a physicochemical examination | Journal of Pineal Research | 2011 | 963 |
5 | Trends in oxidative aging theories | Free Radical Biology and Medicine | 2007 | 897 |
6 | Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry | Journal of Pineal Research | 1995 | 884 |
7 | A review of the evidence supporting melatonin's role as an antioxidant | Journal of Pineal Research | 1995 | 775 |
8 | Melatonin: an ancient molecule that makes oxygen metabolically tolerable | Journal of Pineal Research | 2015 | 751 |
9 | On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK | Journal of Pineal Research | 2013 | 679 |
10 | Measurement of Intracellular Calcium | Physiological Reviews | 1999 | 665 |
11 | Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging | Physiological Genomics | 2003 | 654 |
12 | Activation of innate immune antiviral responses by Nod2 | Nature Immunology | 2009 | 643 |
13 | The chemistry of melatonin's interaction with reactive species | Journal of Pineal Research | 2003 | 630 |
14 | Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate | Journal of Pineal Research | 2008 | 541 |
15 | Melatonin: A Multitasking Molecule | Progress in Brain Research | 2010 | 520 |
16 | A review of the molecular aspects of melatonin’s anti‐inflammatory actions: recent insights and new perspectives | Journal of Pineal Research | 2013 | 511 |
17 | Is the oxidative stress theory of aging dead? | Biochimica Et Biophysica Acta - General Subjects | 2009 | 502 |
18 | Chemical calcium indicators | Methods | 2008 | 460 |
19 | Effects of Melatonin Treatment in Septic Newborns | Pediatric Research | 2001 | 452 |
20 | Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin | Journal of Pineal Research | 2003 | 449 |
21 | Insulin resistance is a cellular antioxidant defense mechanism | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 449 |
22 | Number matters: control of mammalian mitochondrial DNA copy number | Journal of Genetics and Genomics | 2009 | 440 |
23 | Melatonin, energy metabolism, and obesity: a review | Journal of Pineal Research | 2014 | 425 |
24 | Melatonin: Exceeding Expectations | Physiology | 2014 | 401 |
25 | Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review | Journal of Pineal Research | 2014 | 386 |
26 | Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis | Journal of Pineal Research | 2015 | 384 |
27 | Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy | Free Radical Biology and Medicine | 2006 | 378 |
28 | Postmeiotic Sex Chromatin in the Male Germline of Mice | Current Biology | 2006 | 370 |
29 | Melatonin and the ovary: physiological and pathophysiological implications | Fertility and Sterility | 2009 | 363 |
30 | Melatonin, mitochondria, and cellular bioenergetics | Journal of Pineal Research | 2001 | 350 |
31 | Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization | Journal of Pineal Research | 1993 | 349 |
32 | Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis | Journal of Biological Chemistry | 2015 | 347 |
33 | Methionine oxidation and aging | Biochimica Et Biophysica Acta - Proteins and Proteomics | 2005 | 343 |
34 | Free Radical‐Mediated Molecular Damage | Annals of the New York Academy of Sciences | 2001 | 341 |
35 | The Safety of Melatonin in Humans | Clinical Drug Investigation | 2016 | 320 |
36 | Maternally Inherited Aminoglycoside-Induced and Nonsyndromic Deafness Is Associated with the Novel C1494T Mutation in the Mitochondrial 12S rRNA Gene in a Large Chinese Family | American Journal of Human Genetics | 2004 | 316 |
37 | Nuclear localization of melatonin in different mammalian tissues: Immunocytochemical and radioimmunoassay evidence | Journal of Cellular Biochemistry | 1993 | 294 |
38 | The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo | Cancer Letters | 1993 | 290 |
39 | Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. | Genes and Development | 1994 | 286 |
40 | Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2007 | 285 |
41 | Role of redox-regulated transcription factors in inflammation, aging and age-related diseases | Experimental Gerontology | 2000 | 275 |
42 | Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages | Journal of Neuroimmunology | 2005 | 274 |
43 | Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation | FEBS Letters | 1997 | 273 |
44 | Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin | Journal of Cellular Biochemistry | 1997 | 263 |
45 | Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions | Molecules | 2018 | 263 |
46 | Melatonin: Current Status and Future Perspectives in Plant Science | Frontiers in Plant Science | 2015 | 262 |
47 | Oxidative stress of the newborn in the pre‐ and postnatal period and the clinical utility of melatonin | Journal of Pineal Research | 2009 | 261 |
48 | SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin | Autophagy | 2015 | 261 |
49 | Dynamics of Intracellular Movement and Nucleocytoplasmic Recycling of the Ligand-Activated Androgen Receptor in Living Cells | Molecular Endocrinology | 2000 | 258 |
50 | Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity | Obesity Reviews | 2011 | 257 |