| # | Title | Journal | Year | Citations |
|---|
| 1 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene | Science | 1987 | 10,804 |
| 2 | Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction | New England Journal of Medicine | 1998 | 6,163 |
| 3 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp | Diabetes Care | 1999 | 4,832 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 5 | Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome | Circulation | 2000 | 2,113 |
| 6 | The Metabolic Syndrome: Time for a Critical Appraisal: Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes | Diabetes Care | 2005 | 1,936 |
| 7 | NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older | Diabetes | 2003 | 1,332 |
| 8 | Tamoxifen in the Treatment of Breast Cancer | New England Journal of Medicine | 1998 | 1,156 |
| 9 | Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study | Diabetes | 2002 | 992 |
| 10 | Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle | Journal of Clinical Investigation | 2000 | 953 |
| 11 | Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo | Journal of Bone and Mineral Research | 1995 | 897 |
| 12 | TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development | Journal of Clinical Investigation | 1999 | 882 |
| 13 | Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome | Diabetologia | 1991 | 859 |
| 14 | The biology and role of CD44 in cancer progression: therapeutic implications | Journal of Hematology and Oncology | 2018 | 802 |
| 15 | Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. | Journal of Clinical Investigation | 1996 | 760 |
| 16 | Coronary stents: A materials perspective | Biomaterials | 2007 | 741 |
| 17 | Cell Wall and Secreted Proteins ofCandida albicans: Identification, Function, and Expression | Microbiology and Molecular Biology Reviews | 1998 | 648 |
| 18 | Impact of Diabetes on Mortality After the First Myocardial Infarction | Diabetes Care | 1998 | 624 |
| 19 | Inhibition of Candida albicans Biofilm Formation by Farnesol, a Quorum-Sensing Molecule | Applied and Environmental Microbiology | 2002 | 613 |
| 20 | Candida Biofilms: an Update | Eukaryotic Cell | 2005 | 612 |
| 21 | Does the Metabolic Syndrome Improve Identification of Individuals at Risk of Type 2 Diabetes and/or Cardiovascular Disease? | Diabetes Care | 2004 | 608 |
| 22 | National Cholesterol Education Program Versus World Health Organization Metabolic Syndrome in Relation to All-Cause and Cardiovascular Mortality in the San Antonio Heart Study | Circulation | 2004 | 594 |
| 23 | EngineeredControl of Cell Morphology In Vivo Reveals Distinct Roles for Yeast andFilamentous Forms of Candida albicans duringInfection | Eukaryotic Cell | 2003 | 587 |
| 24 | MYH9 is associated with nondiabetic end-stage renal disease in African Americans | Nature Genetics | 2008 | 587 |
| 25 | Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans | Diabetes | 2004 | 585 |
| 26 | The relation of body fat mass and distribution to markers of chronic inflammation | International Journal of Obesity | 2001 | 575 |
| 27 | Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria | Investigational New Drugs | 1992 | 559 |
| 28 | The National Cholesterol Education Program-Adult Treatment Panel III, International Diabetes Federation, and World Health Organization Definitions of the Metabolic Syndrome as Predictors of Incident Cardiovascular Disease and Diabetes | Diabetes Care | 2007 | 522 |
| 29 | Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review | Journal of the National Cancer Institute | 1993 | 511 |
| 30 | Birthweight and adult health outcomes in a biethnic population in the USA | Diabetologia | 1994 | 501 |
| 31 | Relationship Between Hepatic/Visceral Fat and Hepatic Insulin Resistance in Nondiabetic and Type 2 Diabetic Subjects | Gastroenterology | 2007 | 500 |
| 32 | Elevated Risk of Cardiovascular Disease Prior to Clinical Diagnosis of Type 2 Diabetes | Diabetes Care | 2002 | 497 |
| 33 | Increased Insulin Resistance and Insulin Secretion in Nondiabetic African-Americans and Hispanics Compared With Non-Hispanic Whites: The Insulin Resistance Atherosclerosis Study | Diabetes | 1996 | 486 |
| 34 | Management of Dyslipidemia in Adults With Diabetes | Diabetes Care | 1998 | 478 |
| 35 | Establishment of an Osteocyte-like Cell Line, MLO-Y4 | Journal of Bone and Mineral Research | 2010 | 470 |
| 36 | A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes | Diabetes | 2003 | 447 |
| 37 | Influence of particle size on regional lung deposition – What evidence is there? | International Journal of Pharmaceutics | 2011 | 441 |
| 38 | Identification of Persons at High Risk for Type 2 Diabetes Mellitus: Do We Need the Oral Glucose Tolerance Test? | Annals of Internal Medicine | 2002 | 440 |
| 39 | Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients | Antimicrobial Agents and Chemotherapy | 2001 | 435 |
| 40 | Insulin-Resistant Prediabetic Subjects Have More Atherogenic Risk Factors Than Insulin-Sensitive Prediabetic Subjects | Circulation | 2000 | 405 |
| 41 | Steroid hormone receptors in breast cancer management | Breast Cancer Research and Treatment | 1998 | 401 |
| 42 | Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial | Lancet, The | 2019 | 401 |
| 43 | A Bone-Seeking Clone Exhibits Different Biological Properties from the MDA-MB-231 Parental Human Breast Cancer Cells and a Brain-Seeking Clone In Vivo and In Vitro | Journal of Bone and Mineral Research | 2001 | 400 |
| 44 | Reduced Coronary Events in Simvastatin-Treated Patients With Coronary Heart Disease and Diabetes or Impaired Fasting Glucose Levels | Archives of Internal Medicine | 1999 | 395 |
| 45 | Waist Circumference as the Best Predictor of Noninsulin Dependent Diabetes Mellitus (NIDDM) Compared to Body Mass Index, Waist/hip Ratio and Other Anthropometric Measurements in Mexican Americans—A 7‐Year Prospective Study | Obesity | 1997 | 389 |
| 46 | Cancer and Bone* | Endocrine Reviews | 1998 | 388 |
| 47 | Disseminated Phaeohyphomycosis: Review of an Emerging Mycosis | Clinical Infectious Diseases | 2002 | 382 |
| 48 | Fueling the Obesity Epidemic? Artificially Sweetened Beverage Use and Long‐term Weight Gain | Obesity | 2008 | 375 |
| 49 | The metabolic syndrome: time for a critical appraisal | Diabetologia | 2005 | 373 |
| 50 | A Systematic Review of Newer Pharmacotherapies for Depression in Adults: Evidence Report Summary: Clinical Guideline, Part 2 | Annals of Internal Medicine | 2000 | 365 |
