| # | Title | Journal | Year | Citations |
|---|
| 1 | Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke | New England Journal of Medicine | 2008 | 5,749 |
| 2 | Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II) | Lancet, The | 1998 | 3,216 |
| 3 | Family history of subarachnoid haemorrhage: supplemental value of scrutinizing all relatives. | Journal of Neurology, Neurosurgery and Psychiatry | 1997 | 2,568 |
| 4 | Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study | Lancet, The | 2007 | 2,527 |
| 5 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 6 | Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials | Lancet, The | 2010 | 1,871 |
| 7 | Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials | Lancet Neurology, The | 2007 | 1,580 |
| 8 | 'Malignant' Middle Cerebral Artery Territory Infarction | Archives of Neurology | 1996 | 1,291 |
| 9 | Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 1,050 |
| 10 | The Desmoteplase in Acute Ischemic Stroke Trial (DIAS) | Stroke | 2005 | 980 |
| 11 | Combined spatial and temporal imaging of brain activity during visual selective attention in humans | Nature | 1994 | 932 |
| 12 | Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke | Nature Medicine | 2009 | 908 |
| 13 | European Stroke Organization Guidelines for the Management of Intracranial Aneurysms and Subarachnoid Haemorrhage | Cerebrovascular Diseases | 2013 | 884 |
| 14 | Risk Factors, Outcome, and Treatment in Subtypes of Ischemic Stroke: The German Stroke Data Bank | Stroke | 2001 | 839 |
| 15 | Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) | JAMA - Journal of the American Medical Association | 1995 | 828 |
| 16 | EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood | Nature Reviews Clinical Oncology | 2021 | 826 |
| 17 | Patients With Prior Myocardial Infarction, Stroke, or Symptomatic Peripheral Arterial Disease in the CHARISMA Trial | Journal of the American College of Cardiology | 2007 | 752 |
| 18 | Results of the Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE) study to treat symptomatic stenoses at 2 years: a multinational, prospective, randomised trial | Lancet Neurology, The | 2008 | 718 |
| 19 | Early Hemicraniectomy in Patients With Complete Middle Cerebral Artery Infarction | Stroke | 1998 | 694 |
| 20 | MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome | Journal of Neuroinflammation | 2016 | 686 |
| 21 | Moderate Hypothermia in the Treatment of Patients With Severe Middle Cerebral Artery Infarction | Stroke | 1998 | 661 |
| 22 | Artifact Correction of the Ongoing EEG Using Spatial Filters Based on Artifact and Brain Signal Topographies | Journal of Clinical Neurophysiology | 2002 | 650 |
| 23 | Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study | Lancet Neurology, The | 2009 | 640 |
| 24 | A multiple source approach to the correction of eye artifacts | Electroencephalography and Clinical Neurophysiology | 1994 | 632 |
| 25 | NF-κB is activated and promotes cell death in focal cerebral ischemia | Nature Medicine | 1999 | 615 |
| 26 | Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients | Journal of Neuroinflammation | 2012 | 593 |
| 27 | Multiplanar transcranial ultrasound imaging: Standards, landmarks and correlation with magnetic resonance imaging | Ultrasound in Medicine and Biology | 2005 | 555 |
| 28 | Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions | Neuro-Oncology | 2020 | 543 |
| 29 | The immunology of acute stroke | Nature Reviews Neurology | 2012 | 527 |
| 30 | Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion–diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study | Lancet Neurology, The | 2009 | 526 |
| 31 | Mutations in the gene encoding ɛ-sarcoglycan cause myoclonus–dystonia syndrome | Nature Genetics | 2001 | 523 |
| 32 | Thrombolysis with alteplase 3–4·5 h after acute ischaemic stroke (SITS-ISTR): an observational study | Lancet, The | 2008 | 514 |
| 33 | Hemorrhagic Transformation of Ischemic Brain Tissue | Stroke | 2001 | 508 |
| 34 | Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS) | Journal of Neurology | 2014 | 494 |
| 35 | Acute disseminated encephalomyelitis: A follow-up study of 40 adult patients | Neurology | 2001 | 460 |
| 36 | Manganese and chronic hepatic encephalopathy | Lancet, The | 1995 | 431 |
| 37 | Feasibility and Safety of Moderate Hypothermia After Massive Hemispheric Infarction | Stroke | 2001 | 412 |
| 38 | Neuroprotective Effect of Granulocyte Colony–Stimulating Factor After Focal Cerebral Ischemia | Stroke | 2003 | 389 |
| 39 | AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance | Nature Reviews Neurology | 2010 | 384 |
| 40 | Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis | European Journal of Immunology | 2005 | 380 |
| 41 | Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders | Journal of Neuroinflammation | 2011 | 379 |
| 42 | Association of gait and balance disorders with age-related white matter changes | Neurology | 2008 | 374 |
| 43 | Decompressive surgery in space-occupying hemispheric infarction | Critical Care Medicine | 1995 | 367 |
| 44 | Incidence and prognostic significance of fever following intracerebral hemorrhage | Neurology | 2000 | 365 |
| 45 | EHRA Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary† | European Heart Journal | 2013 | 356 |
| 46 | Classification of Stroke Subtypes | Cerebrovascular Diseases | 2009 | 350 |
| 47 | Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort | BMJ: British Medical Journal | 2009 | 348 |
| 48 | A Transgenic Rat Model of Charcot-Marie-Tooth Disease | Neuron | 1996 | 346 |
| 49 | Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke | Brain | 2011 | 346 |
| 50 | Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM | Nature | 2022 | 343 |
