| # | Title | Journal | Year | Citations |
|---|
| 1 | OARSI guidelines for the non-surgical management of knee osteoarthritis | Osteoarthritis and Cartilage | 2014 | 2,298 |
| 2 | Biomedical research: increasing value, reducing waste | Lancet, The | 2014 | 750 |
| 3 | Increasing value and reducing waste: addressing inaccessible research | Lancet, The | 2014 | 692 |
| 4 | Anticoagulation of Pregnant Women With Mechanical Heart Valves | Archives of Internal Medicine | 2000 | 650 |
| 5 | Risk of Menopause During the First Year After Breast Cancer Diagnosis | Journal of Clinical Oncology | 1999 | 503 |
| 6 | Association Between Influenza Vaccination and Cardiovascular Outcomes in High-Risk Patients | JAMA - Journal of the American Medical Association | 2013 | 399 |
| 7 | Understanding the pain experience in hip and knee osteoarthritis – an OARSI/OMERACT initiative | Osteoarthritis and Cartilage | 2008 | 385 |
| 8 | Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families | Nature Medicine | 1996 | 294 |
| 9 | Meta-analysis of Hyperhomocysteinemia as a Risk Factor for Venous Thromboembolic Disease | Archives of Internal Medicine | 1998 | 268 |
| 10 | Deep Vein Thrombosis During Pregnancy and the Puerperium | Obstetrical and Gynecological Survey | 1999 | 252 |
| 11 | Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension | Nature Medicine | 2020 | 251 |
| 12 | Prophylactic Surgery Decisions and Surveillance Practices One Year Following BRCA1/2 Testing | Preventive Medicine | 2000 | 248 |
| 13 | Development and preliminary psychometric testing of a new OA pain measure – an OARSI/OMERACT initiative | Osteoarthritis and Cartilage | 2008 | 245 |
| 14 | Neuropathic pain symptoms in a community knee OA cohort | Osteoarthritis and Cartilage | 2011 | 219 |
| 15 | Pyoderma Gangrenosum: An Update on Pathophysiology, Diagnosis and Treatment | American Journal of Clinical Dermatology | 2017 | 211 |
| 16 | Neuropathic pain symptoms on the modified painDETECT correlate with signs of central sensitization in knee osteoarthritis | Osteoarthritis and Cartilage | 2013 | 205 |
| 17 | Familial Nontoxic Multinodular Thyroid Goiter Locus Maps to Chromosome 14q but Does Not Account for Familial Nonmedullary Thyroid Cancer | American Journal of Human Genetics | 1997 | 203 |
| 18 | Quantitative culture ofMalasseziaspecies from different body sites of individuals with or without dermatoses | Medical Mycology | 2001 | 188 |
| 19 | Comparison of a generic (SF-36) and a disease specific (WOMAC) (Western Ontario and McMaster Universities Osteoarthritis Index) instrument in the measurement of outcomes after knee replacement surgery | Journal of Rheumatology | 1995 | 186 |
| 20 | The changing demographics of total joint arthroplasty recipients in the United States and Ontario from 2001 to 2007 | Best Practice and Research in Clinical Rheumatology | 2012 | 182 |
| 21 | Untreated obstructive sleep apnea and the risk for serious long-term adverse outcomes: A systematic review | Sleep Medicine Reviews | 2014 | 182 |
| 22 | The presence of both an energy deficiency and estrogen deficiency exacerbate alterations of bone metabolism in exercising women | Bone | 2008 | 177 |
| 23 | Which Patients Are Most Likely to Benefit From Total Joint Arthroplasty? | Arthritis and Rheumatism | 2013 | 163 |
| 24 | Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI Extension | BMJ, The | 2020 | 157 |
| 25 | Review: Diabetes, Obesity, and Cancer—Pathophysiology and Clinical Implications | Endocrine Reviews | 2020 | 145 |
| 26 | Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study | BMJ: British Medical Journal | 2018 | 138 |
| 27 | Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension | The Lancet Digital Health | 2020 | 135 |
| 28 | Who, when, and why total joint replacement surgery? The patient's perspective | Current Opinion in Rheumatology | 2006 | 127 |
| 29 | Linkage Analysis of Chromosome 1q Markers in 136 Prostate Cancer Families | American Journal of Human Genetics | 1998 | 123 |
| 30 | Effect of Smoking on Breast Cancer in Carriers of Mutant BRCA1 or BRCA2 Genes | Journal of the National Cancer Institute | 1998 | 118 |
| 31 | Predicting Deep Venous Thrombosis in Pregnancy: Out in “LEFt” Field? | Annals of Internal Medicine | 2009 | 109 |
| 32 | A Population-Based Nested Case-Control Study of the Costs of Hip and Knee Replacement Surgery | Medical Care | 2009 | 108 |
| 33 | The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines | Canadian Journal of Cardiology | 2011 | 106 |
| 34 | The ‘ART’ of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology | Current Opinion in Obstetrics and Gynecology | 2009 | 105 |
| 35 | The relationship between disease symptoms, life events, coping and treatment, and depression among older adults with osteoarthritis | Journal of Rheumatology | 2008 | 103 |
| 36 | Pharmacologic Glycemic Management of Type 2 Diabetes in Adults: 2020 Update | Canadian Journal of Diabetes | 2020 | 98 |
| 37 | Association of Influenza-like Illness Activity With Hospitalizations for Heart Failure | JAMA Cardiology | 2019 | 97 |
| 38 | Gender and Ethnicity Differences in HIV-related Stigma Experienced by People Living with HIV in Ontario, Canada | PLoS ONE | 2012 | 96 |
| 39 | Activation sequence of ventricular tachycardia: Endocardial and epicardial mapping studies in the human ventricle | Journal of the American College of Cardiology | 1987 | 94 |
| 40 | D-dimer testing in pregnant patients: towards determining the next ‘level’ in the diagnosis of deep vein thrombosis | Journal of Thrombosis and Haemostasis | 2010 | 87 |
| 41 | Cost-effectiveness of cancer chemotherapy: an economic evaluation of a randomized trial in small-cell lung cancer. | Journal of Clinical Oncology | 1988 | 86 |
| 42 | Fibroblast Growth Factor-23, Cardiovascular Prognosis, and Benefit of Angiotensin-Converting Enzyme Inhibition in Stable Ischemic Heart Disease | Journal of the American College of Cardiology | 2014 | 84 |
| 43 | Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews | BMJ: British Medical Journal | 2018 | 83 |
| 44 | The association between the combined oral contraceptive pill and insulin resistance, dysglycemia and dyslipidemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of observational studies | Human Reproduction | 2011 | 81 |
| 45 | Importance of Considering Competing Risks in Time-to-Event Analyses | Circulation: Cardiovascular Quality and Outcomes | 2018 | 80 |
| 46 | Mammosomatotroph adenoma of the pituitary associated with gigantism and hyperprolactinemia. A morphological study including immunoelectron microscopy | Acta Neuropathologica | 1986 | 79 |
| 47 | Estrogen status and the renin angiotensin aldosterone system | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2014 | 79 |
| 48 | An Ontario-wide study of vitamin B12, serum folate, and red cell folate levels in relation to plasma homocysteine: is a preventable public health issue on the rise? | Clinical Biochemistry | 2000 | 78 |
| 49 | Cardiovascular Outcomes According to Urinary Albumin and Kidney Disease in Patients With Type 2 Diabetes at High Cardiovascular Risk | JAMA Cardiology | 2018 | 78 |
| 50 | Knee Arthroscopy in England and Ontario: Patterns of Use, Changes Over Time, and Relationship to Total Knee Replacement | Journal of Bone and Joint Surgery - Series A | 2008 | 76 |
