# | Title | Journal | Year | Citations |
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1 | deepTools2: a next generation web server for deep-sequencing data analysis | Nucleic Acids Research | 2016 | 5,157 |
2 | Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons | Cell | 2012 | 3,152 |
3 | Integrative Clinical Genomics of Advanced Prostate Cancer | Cell | 2015 | 2,660 |
4 | 5′ UTR m6A Promotes Cap-Independent Translation | Cell | 2015 | 1,414 |
5 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection | Cell Research | 2014 | 1,282 |
6 | Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome | Nature Methods | 2015 | 1,157 |
7 | Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism | Neuron | 2011 | 1,146 |
8 | Punctuated Evolution of Prostate Cancer Genomes | Cell | 2013 | 1,107 |
9 | Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist | Science | 2010 | 1,034 |
10 | PIP2and Proteins: Interactions, Organization, and Information Flow | Annual Review of Biophysics and Biomolecular Structure | 2002 | 771 |
11 | Bilayer Thickness and Membrane Protein Function: An Energetic Perspective | Annual Review of Biophysics and Biomolecular Structure | 2007 | 738 |
12 | Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH | Science | 2015 | 722 |
13 | Structure and immune recognition of trimeric pre-fusion HIV-1 Env | Nature | 2014 | 702 |
14 | Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis | Nature Genetics | 2012 | 692 |
15 | Novel biomarkers for pre‐diabetes identified by metabolomics | Molecular Systems Biology | 2012 | 605 |
16 | Calculation of absolute protein-ligand binding free energy from computer simulations | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 594 |
17 | Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data | Genome Biology | 2013 | 588 |
18 | Extensive sequencing of seven human genomes to characterize benchmark reference materials | Scientific Data | 2016 | 575 |
19 | Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision | Neuron | 2010 | 544 |
20 | Assembly and diploid architecture of an individual human genome via single-molecule technologies | Nature Methods | 2015 | 465 |
21 | Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions | Science | 2014 | 439 |
22 | A molecular single-cell lung atlas of lethal COVID-19 | Nature | 2021 | 411 |
23 | Transport mechanism of a bacterial homologue of glutamate transporters | Nature | 2009 | 407 |
24 | Shared Molecular Mechanisms of Membrane Transporters | Annual Review of Biochemistry | 2016 | 389 |
25 | Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells | Nature Microbiology | 2016 | 373 |
26 | Metabolic network failures in Alzheimer's disease: A biochemical road map | Alzheimer's and Dementia | 2017 | 362 |
27 | The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site | Molecular Cell | 2008 | 352 |
28 | Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects | Journal of Allergy and Clinical Immunology | 2018 | 344 |
29 | Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding | Science | 2011 | 343 |
30 | Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env | Nature Structural and Molecular Biology | 2015 | 333 |
31 | Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 332 |
32 | A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells | Cell Stem Cell | 2013 | 325 |
33 | Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation | Nature Chemical Biology | 2009 | 323 |
34 | Ultra-stable organic fluorophores for single-molecule research | Chemical Society Reviews | 2014 | 323 |
35 | Energetics of Inclusion-Induced Bilayer Deformations | Biophysical Journal | 1998 | 318 |
36 | A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk | Cell | 2008 | 310 |
37 | Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody | Science | 2016 | 310 |
38 | Regulation, Signaling, and Physiological Functions of G-Proteins | Journal of Molecular Biology | 2016 | 306 |
39 | The binding sites for cocaine and dopamine in the dopamine transporter overlap | Nature Neuroscience | 2008 | 304 |
40 | The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo | Cell | 2015 | 293 |
41 | MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation | Blood | 2009 | 292 |
42 | The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin | Cell | 1999 | 287 |
43 | The Pivotal Regulatory Landscape of RNA Modifications | Annual Review of Genomics and Human Genetics | 2014 | 284 |
44 | Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo | Journal of Experimental Medicine | 2013 | 278 |
45 | Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue | Nature | 2011 | 276 |
46 | EZH2 mutations are frequent and represent an early event in follicular lymphoma | Blood | 2013 | 274 |
47 | Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers. | Journal of General Physiology | 1994 | 273 |
48 | Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers | Nature | 2004 | 271 |
49 | Cyanine fluorophore derivatives with enhanced photostability | Nature Methods | 2012 | 269 |
50 | Membrane Stiffness and Channel Function | Biochemistry | 1996 | 266 |