| # | Title | Journal | Year | Citations |
|---|
| 1 | Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation | Nature Cell Biology | 2018 | 1,101 |
| 2 | Dynamic m6A mRNA methylation directs translational control of heat shock response | Nature | 2015 | 990 |
| 3 | The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity | Cell Metabolism | 2012 | 957 |
| 4 | Nitric Oxide: Pathophysiological Mechanisms | Annual Review of Physiology | 1995 | 838 |
| 5 | The dynamic epitranscriptome: N6-methyladenosine and gene expression control | Nature Reviews Molecular Cell Biology | 2014 | 812 |
| 6 | Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH | Science | 2015 | 722 |
| 7 | PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation | Cell Metabolism | 2011 | 673 |
| 8 | Broccoli: Rapid Selection of an RNA Mimic of Green Fluorescent Protein by Fluorescence-Based Selection and Directed Evolution | Journal of the American Chemical Society | 2014 | 584 |
| 9 | Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction* | Journal of Biological Chemistry | 2006 | 567 |
| 10 | Retinoids, Retinoic Acid Receptors, and Cancer | Annual Review of Pathology: Mechanisms of Disease | 2011 | 487 |
| 11 | m6A enhances the phase separation potential of mRNA | Nature | 2019 | 460 |
| 12 | Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1 | FASEB Journal | 1991 | 449 |
| 13 | NG-methylarginine, and inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo? | Biochemical and Biophysical Research Communications | 1989 | 444 |
| 14 | Metabolomics enables precision medicine: “A White Paper, Community Perspective” | Metabolomics | 2016 | 434 |
| 15 | Central nervous system excitatory effects of meperidine in cancer patients | Annals of Neurology | 1983 | 416 |
| 16 | Identification of arginine as a precursor of endothelium-derived relaxing factor. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 386 |
| 17 | Cryptococcus neoformans var. grubii : Separate Varietal Status for Cryptococcus neoformans Serotype A Isolates | Journal of Clinical Microbiology | 1999 | 385 |
| 18 | Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions | Nature | 1993 | 383 |
| 19 | Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages | Biochemical and Biophysical Research Communications | 1991 | 378 |
| 20 | Cortical 5-HT2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice | Science | 2006 | 375 |
| 21 | Regulation of Stem Cell Pluripotency and Differentiation Involves a Mutual Regulatory Circuit of the Nanog, OCT4, and SOX2 Pluripotency Transcription Factors With Polycomb Repressive Complexes and Stem Cell microRNAs | Stem Cells and Development | 2009 | 375 |
| 22 | The birth of the Epitranscriptome: deciphering the function of RNA modifications | Genome Biology | 2012 | 375 |
| 23 | Mitochondrial oxidative stress in aging and healthspan | Longevity & Healthspan | 2014 | 354 |
| 24 | The d- and l- isomers of methadone bind to the non-competitive site on the N-methyl-d-aspartate (NMDA) receptor in rat forebrain and spinal cord | Neuroscience Letters | 1997 | 343 |
| 25 | Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle | Journal of Biological Chemistry | 1992 | 338 |
| 26 | NAD + metabolism: Bioenergetics, signaling and manipulation for therapy | Biochimica Et Biophysica Acta - Proteins and Proteomics | 2016 | 327 |
| 27 | Retinoids regulate stem cell differentiation | Journal of Cellular Physiology | 2011 | 322 |
| 28 | Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy | Journal of the American College of Cardiology | 2011 | 314 |
| 29 | Nitric Oxide-stimulated Guanine Nucleotide Exchange on p21ras | Journal of Biological Chemistry | 1995 | 309 |
| 30 | Pharmacodynamic and pharmacokinetic differences between drug enantiomers in humans: An overview | Clinical Pharmacology and Therapeutics | 1986 | 302 |
| 31 | NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease | Cell Metabolism | 2014 | 293 |
| 32 | Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models | Neurobiology of Aging | 2013 | 287 |
| 33 | Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 286 |
| 34 | Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine | Biochemical and Biophysical Research Communications | 1990 | 279 |
| 35 | The Roles of Retinoids in Vertebrate Development | Annual Review of Biochemistry | 1995 | 267 |
| 36 | Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome | Science | 2014 | 266 |
| 37 | Retinoids and vertebrate development. | Journal of Biological Chemistry | 1994 | 263 |
| 38 | Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury | Journal of the American Society of Nephrology: JASN | 2011 | 256 |
| 39 | POTENTIALS PRODUCED IN THE SPINAL CORD BY STIMULATION OF DORSAL ROOTS | American Journal of Physiology | 1933 | 255 |
| 40 | Increased stress response and β–phenylethylamine in MAOB–deficient mice | Nature Genetics | 1997 | 251 |
| 41 | Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease | Antioxidants and Redox Signaling | 2012 | 247 |
| 42 | High-fructose corn syrup enhances intestinal tumor growth in mice | Science | 2019 | 243 |
| 43 | PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure | Cell Metabolism | 2011 | 231 |
| 44 | Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase | Neuron | 2012 | 225 |
| 45 | Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: Regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes | Archives of Biochemistry and Biophysics | 1995 | 222 |
| 46 | An Autoinhibitory Control Element Defines Calcium-regulated Isoforms of Nitric Oxide Synthase | Journal of Biological Chemistry | 1997 | 221 |
| 47 | RNA modifications: what have we learned and where are we headed? | Nature Reviews Genetics | 2016 | 215 |
| 48 | The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation | Current Biology | 2014 | 213 |
| 49 | Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart | Cell Reports | 2015 | 213 |
| 50 | Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle | Cell Metabolism | 2014 | 211 |
