| # | Title | Journal | Year | Citations |
|---|
| 1 | Validation of a combined comorbidity index | Journal of Clinical Epidemiology | 1994 | 5,389 |
| 2 | Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia | Nature | 1987 | 2,558 |
| 3 | Breast cancer statistics, 2019 | Ca-A Cancer Journal for Clinicians | 2019 | 2,068 |
| 4 | Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells | Nature Biotechnology | 2010 | 1,080 |
| 5 | Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes | Nature | 2010 | 965 |
| 6 | Direct signaling from astrocytes to neurons in cultures of mammalian brain cells | Science | 1994 | 951 |
| 7 | Incidence of local recurrence and second primary tumors in resected stage I lung cancer | Journal of Thoracic and Cardiovascular Surgery | 1995 | 933 |
| 8 | Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer | Science Translational Medicine | 2010 | 761 |
| 9 | Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration | Nature | 2010 | 686 |
| 10 | Long-Term Survival in Metastatic Transitional-Cell Carcinoma and Prognostic Factors Predicting Outcome of Therapy | Journal of Clinical Oncology | 1999 | 658 |
| 11 | Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice | Cell Stem Cell | 2011 | 635 |
| 12 | Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells | Cell Stem Cell | 2009 | 548 |
| 13 | A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids | Cell Stem Cell | 2020 | 543 |
| 14 | Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer | Cancer Research | 1999 | 494 |
| 15 | High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants | Nature Medicine | 2019 | 485 |
| 16 | Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia. | Journal of Clinical Investigation | 1996 | 468 |
| 17 | Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts | Journal of Biomedical Materials Research Part B | 1997 | 396 |
| 18 | Interleukin‐6 Gene‐Deficient Mice Show Impaired Defense against Pneumococcal Pneumonia | Journal of Infectious Diseases | 1997 | 328 |
| 19 | Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia. | Journal of Clinical Investigation | 1992 | 327 |
| 20 | Local Therapy with Continued EGFR Tyrosine Kinase Inhibitor Therapy as a Treatment Strategy in EGFR-Mutant Advanced Lung Cancers That Have Developed Acquired Resistance to EGFR Tyrosine Kinase Inhibitors | Journal of Thoracic Oncology | 2013 | 313 |
| 21 | Survey of critical care management of comatose, head-injured patients in the United States | Critical Care Medicine | 1995 | 300 |
| 22 | National Cancer Data Base report on esophageal carcinoma | Cancer | 1996 | 299 |
| 23 | Analysis of nipple/areolar involvement with mastectomy: Can the areola be preserved? | Annals of Surgical Oncology | 2002 | 296 |
| 24 | Effects of limited work hours on surgical training | Journal of the American College of Surgeons | 2002 | 290 |
| 25 | Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing | Nature Medicine | 2017 | 285 |
| 26 | Orchestrating liver development | Development (Cambridge) | 2015 | 281 |
| 27 | Identifying Important Predictors for Anastomotic Leak After Colon and Rectal Resection | Annals of Surgery | 2013 | 276 |
| 28 | Radical Total Cystectomy for Cancer of the Bladder: 230 Consecutive Cases Five Years Later | Journal of Urology | 1962 | 275 |
| 29 | Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development | Developmental Cell | 2012 | 269 |
| 30 | Career Satisfaction, Practice Patterns and Burnout among Surgical Oncologists: Report on the Quality of Life of Members of the Society of Surgical Oncology | Annals of Surgical Oncology | 2007 | 257 |
| 31 | Interieukin-10 Impairs Host Defense in Murine Pneumococcal Pneumonia | Journal of Infectious Diseases | 1996 | 253 |
| 32 | Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease | Nature | 2016 | 252 |
| 33 | Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1 | Cell | 2010 | 237 |
| 34 | Lymphomas in dogs a morphologic, immunologic, and clinical study | Cancer | 1990 | 232 |
| 35 | Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis | Cell Reports | 2013 | 224 |
| 36 | Pathologic Ultrastaging Improves Micrometastasis Detection in Sentinel Lymph Nodes During Endometrial Cancer Staging | International Journal of Gynecological Cancer | 2013 | 223 |
| 37 | IL-8 in septic shock, endotoxemia, and after IL-1 administration. | Journal of Immunology | 1991 | 219 |
| 38 | IL-8 in septic shock, endotoxemia, and after IL-1 administration | Journal of Immunology | 1991 | 215 |
| 39 | High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain | Cell Stem Cell | 2017 | 214 |
| 40 | Cachectin/tumor necrosis factor‐α alters red blood cell kinetics and induces anemia in vivo | FASEB Journal | 1989 | 213 |
| 41 | Endogenous IL-10 protects mice from death during septic peritonitis. | Journal of Immunology | 1995 | 212 |
| 42 | Neoadjuvant M-Vac (Methotrexate, Vinblastine, Doxorubicin and Cisplatin) Effect on the Primary Bladder Lesion | Journal of Urology | 1988 | 211 |
| 43 | Antiinflammatory Cytokine Responses during Clinical Sepsis and Experimental Endotoxemia: Sequential Measurements of Plasma Soluble Interleukin (IL)-1 Receptor Type II, IL-10, and IL-13 | Journal of Infectious Diseases | 1997 | 211 |
| 44 | Boron chemicals in diagnosis and therapeutics | Future Medicinal Chemistry | 2013 | 208 |
| 45 | Anticachectin/tumor necrosis factor‐α antibodies attenuate development of cachexia in tumor models | FASEB Journal | 1989 | 205 |
| 46 | Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease | Blood | 1992 | 205 |
| 47 | Retinoic acid signaling pathways in development and diseases | Bioorganic and Medicinal Chemistry | 2014 | 202 |
| 48 | Acute Acalculous Cholecystitis | Gastroenterology Clinics of North America | 2010 | 201 |
| 49 | Conservative Management of Muscle-Infiltrating Bladder Cancer: Prospective Experience | Journal of Urology | 1987 | 199 |
| 50 | Endogenous IL-10 protects mice from death during septic peritonitis | Journal of Immunology | 1995 | 197 |
