| # | Title | Journal | Year | Citations |
|---|
| 1 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases | Nature | 2006 | 5,213 |
| 2 | The immunology of stroke: from mechanisms to translation | Nature Medicine | 2011 | 2,006 |
| 3 | Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease | Nature | 2011 | 1,603 |
| 4 | Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo | Neuron | 1996 | 1,471 |
| 5 | Regulation of NMDA receptor trafficking by amyloid-β | Nature Neuroscience | 2005 | 1,417 |
| 6 | Robot-aided neurorehabilitation | IEEE Transactions on Rehabilitation Engineering: A Publication of the IEEE Engineering in Medicine and Biology Society | 1998 | 1,166 |
| 7 | New roles for astrocytes: Redefining the functional architecture of the brain | Trends in Neurosciences | 2003 | 1,135 |
| 8 | Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease | Journal of Applied Physiology | 2006 | 1,086 |
| 9 | Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo | Neuron | 1996 | 1,054 |
| 10 | Glial regulation of the cerebral microvasculature | Nature Neuroscience | 2007 | 1,003 |
| 11 | Intraneuronal Aβ42 Accumulation in Human Brain | American Journal of Pathology | 2000 | 930 |
| 12 | Distinct cortical areas associated with native and second languages | Nature | 1997 | 903 |
| 13 | Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation | Cell | 2004 | 903 |
| 14 | Brain function in coma, vegetative state, and related disorders | Lancet Neurology, The | 2004 | 888 |
| 15 | Mitochondria take center stage in aging and neurodegeneration | Annals of Neurology | 2005 | 839 |
| 16 | Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease | Trends in Molecular Medicine | 2008 | 799 |
| 17 | Astrocyte-mediated potentiation of inhibitory synaptic transmission | Nature Neuroscience | 1998 | 773 |
| 18 | Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area | Journal of Comparative Neurology | 1992 | 755 |
| 19 | A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus | Nature Medicine | 2001 | 721 |
| 20 | Oxidatively modified proteins in aging and disease1,2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal. | Free Radical Biology and Medicine | 2002 | 719 |
| 21 | Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain | Neuron | 2002 | 701 |
| 22 | Activation of p75NTR by proBDNF facilitates hippocampal long-term depression | Nature Neuroscience | 2005 | 698 |
| 23 | Agmatine: an endogenous clonidine-displacing substance in the brain | Science | 1994 | 696 |
| 24 | Parkinson's disease | Human Molecular Genetics | 2007 | 691 |
| 25 | Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain | Nature Medicine | 2003 | 675 |
| 26 | Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology | American Journal of Pathology | 2002 | 664 |
| 27 | Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis | Nature Clinical Practice Neurology | 2008 | 643 |
| 28 | Mitochondrial -Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species | Journal of Neuroscience | 2004 | 626 |
| 29 | Movement Smoothness Changes during Stroke Recovery | Journal of Neuroscience | 2002 | 608 |
| 30 | Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo | Neuron | 2003 | 594 |
| 31 | Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice | Nature Biotechnology | 2003 | 585 |
| 32 | Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia | Journal of Neuroscience | 1990 | 581 |
| 33 | Mitochondrial Dysfunction in Neurodegenerative Diseases | Journal of Pharmacology and Experimental Therapeutics | 2012 | 557 |
| 34 | Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease | Experimental and Molecular Medicine | 2006 | 552 |
| 35 | Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides | Science | 1993 | 541 |
| 36 | A novel approach to stroke rehabilitation | Neurology | 2000 | 532 |
| 37 | Nature and precision of temporal coding in visual cortex: a metric-space analysis | Journal of Neurophysiology | 1996 | 526 |
| 38 | Mutated Human SOD1 Causes Dysfunction of Oxidative Phosphorylation in Mitochondria of Transgenic Mice | Journal of Biological Chemistry | 2002 | 522 |
| 39 | Recovery of consciousness after brain injury: a mesocircuit hypothesis | Trends in Neurosciences | 2010 | 502 |
| 40 | Adenoviral Brain-Derived Neurotrophic Factor Induces Both Neostriatal and Olfactory Neuronal Recruitment from Endogenous Progenitor Cells in the Adult Forebrain | Journal of Neuroscience | 2001 | 484 |
| 41 | Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling | Journal of Neuroscience | 2001 | 460 |
| 42 | Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites | Journal of Comparative Neurology | 2001 | 457 |
| 43 | Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 451 |
| 44 | Gap-junction-mediated propagation and amplification of cell injury | Nature Neuroscience | 1998 | 445 |
| 45 | Optimization of differential immunogold-silver and peroxidase labeling with maintenance of ultrastructure in brain sections before plastic embedding | Journal of Neuroscience Methods | 1990 | 442 |
| 46 | Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease | Annals of the New York Academy of Sciences | 2003 | 439 |
| 47 | In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other | Brain Research | 1990 | 433 |
| 48 | The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons | Journal of Neuroscience | 1996 | 430 |
| 49 | Hypertension and Cerebrovascular Dysfunction | Cell Metabolism | 2008 | 425 |
| 50 | Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation | Cell Metabolism | 2009 | 422 |
